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Tbio
RALA
Ras-related protein Ral-A

Protein Summary
Description
Multifunctional GTPase involved in a variety of cellular processes including gene expression, cell migration, cell proliferation, oncogenic transformation and membrane trafficking. Accomplishes its multiple functions by interacting with distinct downstream effectors. Acts as a GTP sensor for GTP-dependent exocytosis of dense core vesicles. The RALA-exocyst complex regulates integrin-dependent membrane raft exocytosis and growth signaling (PubMed:20005108). Key regulator of LPAR1 signaling and competes with GRK2 for binding to LPAR1 thus affecting the signaling properties of the receptor. Required for anchorage-independent proliferation of transformed cells (PubMed:19306925). During mitosis, supports the stabilization and elongation of the intracellular bridge between dividing cells. Cooperates with EXOC2 to recruit other components of the exocyst to the early midbody (PubMed:18756269). The product of this gene belongs to the small GTPase superfamily, Ras family of proteins. GTP-binding ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000005257
  • ENSP00000005257
  • ENSG00000006451

Symbol
  • RAL
  • RAL
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.99
transcription factor perturbation
0.97
interacting protein
0.93
kinase perturbation
0.88
disease perturbation
0.83


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.67   (req: < 5)
Gene RIFs: 60   (req: <= 3)
Antibodies: 332   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 416.67   (req: >= 5)
Gene RIFs: 60   (req: > 3)
Antibodies: 332   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS like proto-oncogene A
VGNC:10412
737424
Mouse
MGI:1927243
56044
Rat
RGD:619851
81757
Dog
RAS like proto-oncogene A
VGNC:45330
475875
Horse
RAS like proto-oncogene A
VGNC:22159
100051360
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS like proto-oncogene A
Mouse
Rat
Dog
RAS like proto-oncogene A
Horse
RAS like proto-oncogene A
Protein Structure (6 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11233-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 6
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Reactome
Immune System
Reactome
Interleukin-12 family signaling
Reactome
Interleukin-12 signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation
Immune System
Interleukin-12 family signaling
Interleukin-12 signaling
Gene Ontology Terms (28)
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (150)
1 – 10 of 150
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.999898585
p_ni: 0.000101414
p_wrong: 1e-9
Data Source: BioPlex
ANKRD13A
Tbio
Novelty: 0.61940334
p_int: 0.929493749
p_ni: 0.070506251
Data Source: BioPlex
EXOC2
Tbio
Novelty: 0.01434464
Score: 0.999
Data Source: STRINGDB
RALBP1
Tbio
Novelty: 0.01525176
Score: 0.998
Data Source: STRINGDB
EXOC8
Tbio
Novelty: 0.03090842
Score: 0.993
Data Source: STRINGDB
RALGDS
Tbio
Novelty: 0.00362484
Score: 0.986
Data Source: Reactome,STRINGDB
EXOC7
Tbio
Novelty: 0.00852508
Score: 0.984
Data Source: STRINGDB
EXOC1
Tbio
Novelty: 0.01073858
Score: 0.981
Data Source: STRINGDB
EXOC4
Tbio
Novelty: 0.01636648
Score: 0.979
Data Source: STRINGDB
EXOC3
Tbio
Novelty: 0.01051955
Score: 0.978
Data Source: STRINGDB
Publication Statistics
PubMed Score  416.67

PubMed score by year
PubTator Score  313.01

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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