CHRNB1
Acetylcholine receptor subunit beta
Protein Summary
After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The muscle acetylcholine receptor is composed of five subunits: two alpha subunits and one beta, one gamma, and one delta subunit. This gene encodes the beta subunit of the acetylcholine receptor. The acetylcholine receptor changes conformation upon acetylcholine binding leading to the opening of an ion-conducting channel across the plasma membrane. Mutations in this gene are associated with slow-channel congenital myasthenic syndrome. [provided by RefSeq, Jul 2008]
- ENST00000306071
- ENSP00000304290
- ENSG00000170175
- ENST00000536404
- ENSP00000439209
- ENST00000639692
- ENSP00000492221
- ENSG00000283946
- ENST00000639993
- ENSP00000491113
- ACHRB
- CHRNB
- ACHRB
- CHRNB
- CMS1D
- CMS2A
- CMS2C
- SCCMS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.96 | ||
protein domain | 0.85 | ||
gene perturbation | 0.83 | ||
small molecule perturbation | 0.65 | ||
disease perturbation | 0.62 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.42 (req: < 5)
Gene RIFs: 12 (req: <= 3)
Antibodies: 242 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 25.42 (req: >= 5)
Gene RIFs: 12 (req: > 3)
Antibodies: 242 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 13