PYGM
Glycogen phosphorylase, muscle form
Protein Summary
Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. This gene encodes a muscle enzyme involved in glycogenolysis. Highly similar enzymes encoded by different genes are found in liver and brain. Mutations in this gene are associated with McArdle disease (myophosphorylase deficiency), a glycogen storage disease of muscle. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Sep 2009]
- ENST00000164139
- ENSP00000164139
- ENSG00000068976
- ENST00000377432
- ENSP00000366650
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
virus perturbation | 0.72 | ||
cellular component | 0.68 | ||
gene perturbation | 0.66 | ||
molecular function | 0.63 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.4 (req: < 5)
Gene RIFs: 40 (req: <= 3)
Antibodies: 276 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 201.4 (req: >= 5)
Gene RIFs: 40 (req: > 3)
Antibodies: 276 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 7
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 79
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0