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Tbio
ITGAM
Integrin alpha-M

Protein Summary
Description
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000287497
  • ENSP00000287497
  • ENSG00000169896
  • ENST00000544665
  • ENSP00000441691
  • ENST00000648685
  • ENSP00000496959

Symbol
  • CD11B
  • CR3A
  • CR3A
  • MO1A
  • CD11B
  • MAC-1
  • MAC1A
  • SLEB6
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
0.95
protein domain
0.85
cellular component
0.77
disease
0.75
disease perturbation
0.74


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5279.01   (req: < 5)
Gene RIFs: 235   (req: <= 3)
Antibodies: 2896   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5279.01   (req: >= 5)
Gene RIFs: 235   (req: > 3)
Antibodies: 2896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
11
6
0
1.7
99.5
1
1
0
1.3
54.7
serum metabolite measurement
1
1
1
31.6
apolipoprotein A 1 measurement
1
1
1
18.4
1
1
0
1.2
14.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.7
99.5
0
1.3
54.7
serum metabolite measurement
1
31.6
apolipoprotein A 1 measurement
1
18.4
0
1.2
14.7
Orthologs (9)
1 – 5 of 9
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha M
VGNC:5826
454069
Mouse
MGI:96607
16409
Rat
Dog
integrin subunit alpha M
VGNC:42133
489928
Horse
integrin subunit alpha M
VGNC:19173
100064803
Species
Name
OMA
EggNOG
Inparanoid
Chimp
integrin subunit alpha M
Mouse
Rat
Dog
integrin subunit alpha M
Horse
integrin subunit alpha M
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11215-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (39)
Cell surface interactions at the vascular wall (R-HSA-202733)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell surface interactions at the vascular wall
Reactome
Cytokine Signaling in Immune system
Reactome
Extracellular matrix organization
Reactome
Hemostasis
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cell surface interactions at the vascular wall
Cytokine Signaling in Immune system
Extracellular matrix organization
Hemostasis
Immune System
Protein-Protein Interactions (682)
1 – 10 of 682
ANK1
Tbio
Novelty: 0.00225305
Score: 0.999
Data Source: STRINGDB
ITGB2
Tclin
Novelty: 0.00185859
Score: 0.992
Data Source: Reactome,STRINGDB
C3
Tbio
Novelty: 0.00019115
Score: 0.991
Data Source: STRINGDB
ICAM1
Tchem
Novelty: 0.00009746
Score: 0.991
Data Source: STRINGDB
THY1
Tbio
Novelty: 0.00032846
Score: 0.987
Data Source: STRINGDB
FCGR2A
Tbio
Novelty: 0.00078918
Score: 0.987
Data Source: STRINGDB
CD14
Tbio
Novelty: 0.00872424
Score: 0.985
Data Source: Reactome,STRINGDB
CD33
Tclin
Novelty: 0.00074958
Score: 0.981
Data Source: STRINGDB
CYBB
Tchem
Family: IC
Novelty: 0.00054866
Score: 0.977
Data Source: STRINGDB
ICAM2
Tbio
Novelty: 0.00480584
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  5279.01

PubMed score by year
PubTator Score  2163.68

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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