Tbio ITGAM Integrin alpha-M

Protein Summary

Description

Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as macrophage receptor 1 ('Mac-1'), or inactivated-C3b (iC3b) receptor 3 ('CR3'). The alpha M beta 2 integrin is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]

Uniprot Accession IDs

• P11215
• Q4VAK0
• Q4VAK1
• Q4VAK2

Gene Name

• ITGAM

Ensembl ID

• ENST00000287497
• ENSP00000287497
• ENSG00000169896
• ENST00000544665
• ENSP00000441691
• ENST00000648685
• ENSP00000496959

Symbol

• CD11B
• CR3A
• CR3A
• MO1A
• CD11B
• MAC-1
• MAC1A
• SLEB6

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
chemical	0.95
protein domain	0.85
cellular component	0.77
disease	0.75
disease perturbation	0.74

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GENEVA

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5279.01   (req: < 5)

Gene RIFs: 235   (req: <= 3)

Antibodies: 2896   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5279.01   (req: >= 5)

Gene RIFs: 235   (req: > 3)

Antibodies: 2896   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 28

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (5)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	11	6	0	1.7	99.5
systemic scleroderma	EFO_0000717	1	1	0	1.3	54.7
serum metabolite measurement	EFO_0005653	1	1	1		31.6
apolipoprotein A 1 measurement	EFO_0004614	1	1	1		18.4
IGA glomerulonephritis	EFO_0004194	1	1	0	1.2	14.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
systemic lupus erythematosus	EFO_0002690	0	1.7	99.5
systemic scleroderma	EFO_0000717	0	1.3	54.7
serum metabolite measurement	EFO_0005653	1		31.6
apolipoprotein A 1 measurement	EFO_0004614	1		18.4
IGA glomerulonephritis	EFO_0004194	0	1.2	14.7

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Orthologs (9)

1 – 5 of 9

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha M	VGNC:5826	454069
Mouse	integrin alpha M	MGI:96607	16409
Rat	integrin subunit alpha D [Source:RGD Symbol;Acc:71075]
Dog	integrin subunit alpha M	VGNC:42133	489928
Horse	integrin subunit alpha M	VGNC:19173	100064803

Species	Name	OMA	EggNOG	Inparanoid
Chimp	integrin subunit alpha M
Mouse	integrin alpha M
Rat	integrin subunit alpha D [Source:RGD Symbol;Acc:71075]
Dog	integrin subunit alpha M
Horse	integrin subunit alpha M

Protein Structure (16 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11215-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (39)

Reactome (12)

KEGG (15)

PathwayCommons (6)

WikiPathways (6)

Cell surface interactions at the vascular wall (R-HSA-202733)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Reactome	Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Reactome	Extracellular matrix organization	297 targets	R-HSA-1474244
Reactome	Hemostasis	666 targets	R-HSA-109582
Reactome	Immune System	2246 targets	R-HSA-168256

Name	Explore in Pharos	Explore in Source
Cell surface interactions at the vascular wall	211 targets	R-HSA-202733
Cytokine Signaling in Immune system	922 targets	R-HSA-1280215
Extracellular matrix organization	297 targets	R-HSA-1474244
Hemostasis	666 targets	R-HSA-109582
Immune System	2246 targets	R-HSA-168256

Gene Ontology Terms (38)

Functions (4)

Components (10)

Processes (24)

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10

1 – 4 of 4

GO Term	Evidence	Assigned by
heat shock protein binding	Inferred from Physical Interaction (IPI)	CAFA
complement component C3b binding	Inferred from Sequence or structural Similarity (ISS)	ARUK-UCL
protein heterodimerization activity	Non-traceable Author Statement (NAS)	ARUK-UCL
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (682)

Explore Interacting Targets

1 – 10 of 682

• See Interactions on String-DB

ANK1

Tbio

Novelty: 0.00225305

Score: 0.999

Data Source: STRINGDB

ITGB2

Tclin

Novelty: 0.00185859

Score: 0.992

Data Source: Reactome,STRINGDB

C3

Tbio

Novelty: 0.00019115

Score: 0.991

Data Source: STRINGDB

ICAM1

Tchem

Novelty: 0.00009746

Score: 0.991

Data Source: STRINGDB

THY1

Tbio

Novelty: 0.00032846

Score: 0.987

Data Source: STRINGDB

FCGR2A

Tbio

Novelty: 0.00078918

Score: 0.987

Data Source: STRINGDB

CD14

Tbio

Novelty: 0.00872424

Score: 0.985

Data Source: Reactome,STRINGDB

CD33

Tclin

Novelty: 0.00074958

Score: 0.981

Data Source: STRINGDB

CYBB

Tchem

Family: IC

Novelty: 0.00054866

Score: 0.977

Data Source: STRINGDB

ICAM2

Tbio

Novelty: 0.00480584

Score: 0.973

Data Source: STRINGDB

Publication Statistics

PubMed Score  5279.01

PubMed score by year

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PubTator Score  2163.68

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Alternative splicing
Calcium
Cell adhesion
Cell membrane
Complete proteome
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunity

GWAS Trait Find Similar Targets

apolipoprotein A 1 measurement
IGA glomerulonephritis
serum metabolite measurement
systemic lupus erythematosus
systemic scleroderma

MGI Phenotype Find Similar Targets

cellular phenotype
hematopoietic system phenotype
homeostasis/metabolism phenotype
immune system phenotype
nervous system phenotype