Protein Summary
Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles. It is identical with CR-3, the receptor for the iC3b fragment of the third complement component. It probably recognizes the R-G-D peptide in C3b. Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1. It recognizes P1 and P2 peptides of fibrinogen gamma chain. Regulates neutrophil migration (PubMed:28807980). In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407). May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity). May play a role in mast cell development (By similarity). This gene encodes the integrin alpha M chain. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This I-domain containing alpha integrin combines with the beta ...more
- ENST00000287497
- ENSP00000287497
- ENSG00000169896
- ENST00000544665
- ENSP00000441691
- ENST00000648685
- ENSP00000496959
- CD11B
- CR3A
- CR3A
- MO1A
- CD11B
- MAC-1
- MAC1A
- SLEB6
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
chemical | 0.95 | ||
protein domain | 0.85 | ||
cellular component | 0.77 | ||
disease | 0.75 | ||
disease perturbation | 0.74 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5990.9 (req: < 5)
Gene RIFs: 235 (req: <= 3)
Antibodies: 2896 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5990.9 (req: >= 5)
Gene RIFs: 235 (req: > 3)
Antibodies: 2896 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 28
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (682)
Nearest Tclin Targets (8)
Upstream (2)
Downstream (6)
1 – 2 of 2
ITGB2
Pathways (39)
Reactome (12)
KEGG (15)
PathwayCommons (6)
WikiPathways (6)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cell surface interactions at the vascular wall | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Extracellular matrix organization | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cell surface interactions at the vascular wall | ||||
Cytokine Signaling in Immune system | ||||
Extracellular matrix organization | ||||
Hemostasis | ||||
Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (4)
Components (10)
Processes (24)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Physical Interaction (IPI) | CAFA | |||
Inferred from Sequence or structural Similarity (ISS) | ARUK-UCL | |||
Non-traceable Author Statement (NAS) | ARUK-UCL | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (24)
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
13 | 7 | 0 | 1.7 | 99.6 | |||||
2 | 3 | 0 | 1.2 | 93.8 | |||||
blood protein measurement | 3 | 5 | 5 | 86.5 | |||||
Glycosuria | 2 | 1 | 0 | 1.2 | 70.5 | ||||
1 | 1 | 0 | 1.3 | 64.4 | |||||
Items per page:
1 – 5 of 24
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.7 | 99.6 | |||||
0 | 1.2 | 93.8 | |||||
blood protein measurement | 5 | 86.5 | |||||
Glycosuria | 0 | 1.2 | 70.5 | ||||
0 | 1.3 | 64.4 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha M | VGNC:5826 | 454069 | |||||
Mouse | MGI:96607 | 16409 | ||||||
Rat | ||||||||
Dog | integrin subunit alpha M | VGNC:42133 | 489928 | |||||
Horse | integrin subunit alpha M | VGNC:19173 | 100064803 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | integrin subunit alpha M | |||||
Mouse | ||||||
Rat | ||||||
Dog | integrin subunit alpha M | |||||
Horse | integrin subunit alpha M | |||||
Publication Statistics
PubMed Score 5990.90
PubMed score by year
PubTator Score 2163.68
PubTator score by year
Related Publications
Text Mined References (291)
GeneRif Annotations (235)
Items per page:
0 of 0
PMID | Year | Title |
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