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Tbio
PDHB
Pyruvate dehydrogenase E1 component subunit beta, mitochondrial

Protein Summary
Description
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. The pyruvate dehydrogenase (PDH) complex is a nuclear-encoded mitochondrial multienzyme complex that catalyzes the overall conversion of pyruvate to acetyl-CoA and carbon dioxide, and provides the primary link between glycolysis and the tricarboxylic acid (TCA) cycle. The PDH complex is composed of multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). The E1 enzyme is a heterotetramer of two alpha and two beta subunits. This gene encodes the E1 beta subunit. Mutations in this gene are associated with pyruvate dehydrogenase E1-beta deficiency. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000302746
  • ENSP00000307241
  • ENSG00000168291
  • ENST00000383714
  • ENSP00000373220
  • ENST00000485460
  • ENSP00000417267

Symbol
  • PHE1B
  • PDHBD
  • PHE1B
  • PDHE1B
  • PDHE1-B
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.96
histone modification site profile
0.88
interacting protein
0.87
co-expressed gene
0.85
kinase perturbation
0.76


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: < 5)
Gene RIFs: 10   (req: <= 3)
Antibodies: 214   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 97.58   (req: >= 5)
Gene RIFs: 10   (req: > 3)
Antibodies: 214   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.1
66.3
alcohol abuse
1
1
1
9.2
aspartate aminotransferase measurement
1
1
1
9.2
low density lipoprotein cholesterol measurement
1
1
1
5.6
apolipoprotein B measurement
1
1
1
4.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
66.3
alcohol abuse
1
9.2
aspartate aminotransferase measurement
1
9.2
low density lipoprotein cholesterol measurement
1
5.6
apolipoprotein B measurement
1
4.6
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase E1 beta subunit
VGNC:48921
470832
Macaque
pyruvate dehydrogenase E1 beta subunit
574227
Mouse
MGI:1915513
68263
Rat
RGD:1359146
289950
Dog
pyruvate dehydrogenase E1 beta subunit
476574
Species
Name
OMA
EggNOG
Inparanoid
Chimp
pyruvate dehydrogenase E1 beta subunit
Macaque
pyruvate dehydrogenase E1 beta subunit
Mouse
Rat
Dog
pyruvate dehydrogenase E1 beta subunit
Protein Structure (9 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11177-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (24)
Glyoxylate metabolism and glycine degradation (R-HSA-389661)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Metabolism
Reactome
Metabolism of amino acids and derivatives
Reactome
Pyruvate metabolism
Reactome
Pyruvate metabolism and Citric Acid (TCA) cycle
Name
Explore in Pharos
Explore in Source
Glyoxylate metabolism and glycine degradation
Metabolism
Metabolism of amino acids and derivatives
Pyruvate metabolism
Pyruvate metabolism and Citric Acid (TCA) cycle
Protein-Protein Interactions (207)
1 – 10 of 207
PDK3
Tchem
Family: Kinase
Novelty: 0.05009442
p_int: 0.999999846
p_ni: 1.54e-7
Score: 0.992
Data Source: BioPlex,Reactome,STRINGDB
PPP3CC
Tbio
Family: Enzyme
Novelty: 0.02633046
p_int: 0.999930798
p_ni: 0.000069202
Score: 0.539
Data Source: BioPlex,STRINGDB
PDHA1
Tbio
Family: Enzyme
Novelty: 0.00392231
p_int: 0.999873864
p_ni: 0.000126136
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
BANP
Tbio
Novelty: 0.02145545
p_int: 0.999364756
p_ni: 0.000634348
p_wrong: 8.96e-7
Data Source: BioPlex
PPP3CB
Tbio
Family: Enzyme
Novelty: 0.02156713
p_int: 0.999150471
p_ni: 0.000849529
Score: 0.631
Data Source: BioPlex,STRINGDB
PPP3R1
Tbio
Novelty: 0.00263264
p_int: 0.998936616
p_ni: 0.001063344
p_wrong: 4e-8
Score: 0.706
Data Source: BioPlex,STRINGDB
PDHX
Tbio
Family: Enzyme
Novelty: 0.00946631
p_int: 0.998125424
p_ni: 0.001874576
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DLAT
Tbio
Family: Enzyme
Novelty: 0.00311191
p_int: 0.996133986
p_ni: 0.003866014
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
PPP3CA
Tchem
Family: Enzyme
Novelty: 0.00234189
p_int: 0.993985442
p_ni: 0.006014558
Score: 0.523
Data Source: BioPlex,STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00214298
p_int: 0.991880956
p_ni: 0.008119044
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Publication Statistics
PubMed Score  97.58

PubMed score by year
PubTator Score  24.26

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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