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Tclin
UMPS
Uridine 5'-monophosphate synthase

Protein Summary
Description
This gene encodes a uridine 5'-monophosphate synthase. The encoded protein is a bifunctional enzyme that catalyzes the final two steps of the de novo pyrimidine biosynthetic pathway. The first reaction is carried out by the N-terminal enzyme orotate phosphoribosyltransferase which converts orotic acid to orotidine-5'-monophosphate. The terminal reaction is carried out by the C-terminal enzyme OMP decarboxylase which converts orotidine-5'-monophosphate to uridine monophosphate. Defects in this gene are the cause of hereditary orotic aciduria. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
protein domain
0.99
virus perturbation
0.99
disease perturbation
0.83
transcription factor binding site profile
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.37   (req: < 5)
Gene RIFs: 33   (req: <= 3)
Antibodies: 188   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 109.37   (req: >= 5)
Gene RIFs: 33   (req: > 3)
Antibodies: 188   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
oteracil
chemical structure image
GWAS Traits (5)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
6
3
4
1.1
83.7
mean platelet volume
2
1
2
63.9
platelet crit
1
1
1
50.9
1
1
0
1.1
44
mean corpuscular volume
1
1
1
10.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
4
1.1
83.7
mean platelet volume
2
63.9
platelet crit
1
50.9
0
1.1
44
mean corpuscular volume
1
10.7
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uridine monophosphate synthetase
VGNC:12223
460644
Macaque
uridine monophosphate synthetase
715664
Mouse
MGI:1298388
22247
Rat
RGD:1311908
288051
Dog
uridine monophosphate synthetase
VGNC:48132
478593
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uridine monophosphate synthetase
Macaque
uridine monophosphate synthetase
Mouse
Rat
Dog
uridine monophosphate synthetase
Protein Structure (38 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11172-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 38
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (18)
Metabolism (R-HSA-1430728)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Metabolism
Reactome
Metabolism of nucleotides
Reactome
Nucleobase biosynthesis
Reactome
Pyrimidine biosynthesis
Name
Explore in Pharos
Explore in Source
Metabolism
Metabolism of nucleotides
Nucleobase biosynthesis
Pyrimidine biosynthesis
Protein-Protein Interactions (214)
1 – 10 of 214
S100A4
Tbio
Novelty: 0.00136919
p_int: 0.963202246
p_ni: 0.036797754
Data Source: BioPlex
EPHA4
Tchem
Family: Kinase
Novelty: 0.00321698
p_int: 0.853962151
p_ni: 0.146037844
p_wrong: 5e-9
Score: 0.263
Data Source: BioPlex,STRINGDB
DPYD
Tclin
Family: Enzyme
Novelty: 0.00207216
Score: 0.994
Data Source: STRINGDB
DHODH
Tclin
Family: Enzyme
Novelty: 0.00217565
Score: 0.99
Data Source: STRINGDB
TYMP
Tclin
Family: Enzyme
Novelty: 0.0015906
Score: 0.983
Data Source: STRINGDB
UPP1
Tchem
Family: Enzyme
Novelty: 0.01384975
Score: 0.979
Data Source: STRINGDB
UCKL1
Tbio
Family: Kinase
Novelty: 0.18522799
Score: 0.978
Data Source: STRINGDB
UCK2
Tbio
Family: Kinase
Novelty: 0.02417595
Score: 0.975
Data Source: STRINGDB
UCK1
Tbio
Family: Kinase
Novelty: 0.10536869
Score: 0.974
Data Source: STRINGDB
CMPK1
Tbio
Family: Kinase
Novelty: 0.01478492
Score: 0.972
Data Source: STRINGDB
Publication Statistics
PubMed Score  109.37

PubMed score by year
PubTator Score  259.44

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer