EPB41
Protein 4.1
Protein Summary
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
- ENST00000343067
- ENSP00000345259
- ENSG00000159023
- ENST00000347529
- ENSP00000290100
- ENST00000373797
- ENSP00000362903
- ENST00000373798
- ENSP00000362904
- ENST00000373800
- ENSP00000362906
- ENST00000642260
- ENSP00000495565
- E41P
- HE
- EL1
- 4.1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.97 | ||
transcription factor | 0.94 | ||
hub protein | 0.92 | ||
interacting protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 787.82 (req: < 5)
Gene RIFs: 63 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 787.82 (req: >= 5)
Gene RIFs: 63 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0