You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
EPB41
Protein 4.1

Protein Classes
DTO ClassesZinc Finger Protein 491
Protein Summary
Description
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000343067
  • ENSP00000345259
  • ENSG00000159023
  • ENST00000347529
  • ENSP00000290100
  • ENST00000373797
  • ENSP00000362903
  • ENST00000373798
  • ENSP00000362904
  • ENST00000373800
  • ENSP00000362906
  • ENST00000642260
  • ENSP00000495565

Symbol
  • E41P
  • HE
  • EL1
  • 4.1R
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
1
kinase perturbation
0.97
transcription factor
0.94
hub protein
0.92
interacting protein
0.88


IDG Partner Tools
GlyGen
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.27   (req: < 5)
View Publications
Gene RIFs: 58   (req: <= 3)
View Gene RIFs
Antibodies: 324   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 737.27   (req: >= 5)
Gene RIFs: 58   (req: > 3)
Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
EFO_0010701
1
3
3
70.8
mean corpuscular volume
EFO_0004526
1
2
2
68.2
sex hormone-binding globulin measurement
EFO_0004696
1
1
1
57.5
reticulocyte measurement
EFO_0010700
2
1
2
47.2
reticulocyte count
EFO_0007986
2
1
2
46.3
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mean reticulocyte volume
EFO_0010701
3
70.8
mean corpuscular volume
EFO_0004526
2
68.2
sex hormone-binding globulin measurement
EFO_0004696
1
57.5
reticulocyte measurement
EFO_0010700
2
47.2
reticulocyte count
EFO_0007986
2
46.3
Protein Data Bank (3)
1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (7)
Neurexins and neuroligins (R-HSA-6794361)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neurexins and neuroligins
60 targets
R-HSA-6794361
Reactome
Neuronal System
398 targets
R-HSA-112316
Reactome
Protein-protein interactions at synapses
91 targets
R-HSA-6794362
Name
Explore in Pharos
Explore in Source
Neurexins and neuroligins
60 targets
R-HSA-6794361
Neuronal System
398 targets
R-HSA-112316
Protein-protein interactions at synapses
91 targets
R-HSA-6794362
Gene Ontology Terms (27)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
1-phosphatidylinositol binding
Inferred from Direct Assay (IDA)
UniProtKB
phosphoprotein binding
Inferred from Mutant Phenotype (IMP)
CAFA
protein C-terminus binding
Inferred from Mutant Phenotype (IMP)
CAFA
protein N-terminus binding
Inferred from Mutant Phenotype (IMP)
CAFA
spectrin binding
Traceable Author Statement (TAS)
BHF-UCL
structural constituent of cytoskeleton
Traceable Author Statement (TAS)
ProtInc
actin binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
calmodulin binding
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (133)
1 – 10 of 133
EPB41L1
Tbio
Novelty: 0.02937451
p_int: 0.997235216
p_ni: 0.002764783
p_wrong: 1e-9
Score: 0.908
Data Source: BioPlex,STRINGDB
EPB41L3
Tbio
Novelty: 0.00915217
p_int: 0.996128988
p_ni: 0.003871012
Score: 0.908
Data Source: BioPlex,STRINGDB
CASK
Tchem
Family: Kinase
Novelty: 0.00856437
Score: 0.965
Data Source: Reactome,STRINGDB
NRXN2
Tbio
Novelty: 0.01252742
Score: 0.963
Data Source: STRINGDB
NRXN2
Tbio
Novelty: 0.01252742
Score: 0.963
Data Source: STRINGDB
NRXN3
Tbio
Novelty: 0.00999084
Score: 0.961
Data Source: STRINGDB
NRXN3
Tbio
Novelty: 0.00999084
Score: 0.961
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.96
Data Source: STRINGDB
NRXN1
Tbio
Novelty: 0.00454659
Score: 0.96
Data Source: STRINGDB
SDC2
Tbio
Novelty: 0.00597758
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  737.27

PubMed score by year
PubTator Score  572.46

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: