Protein Summary
Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]
- ENST00000343067
- ENSP00000345259
- ENSG00000159023
- ENST00000347529
- ENSP00000290100
- ENST00000373797
- ENSP00000362903
- ENST00000373798
- ENSP00000362904
- ENST00000373800
- ENSP00000362906
- ENST00000642260
- ENSP00000495565
- E41P
- HE
- EL1
- 4.1R
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
protein domain | 1 | ||
kinase perturbation | 0.97 | ||
transcription factor | 0.94 | ||
hub protein | 0.92 | ||
interacting protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 741.85 (req: < 5)
Gene RIFs: 58 (req: <= 3)
Antibodies: 324 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 741.85 (req: >= 5)
Gene RIFs: 58 (req: > 3)
Antibodies: 324 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 17
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (133)
EPB41L1
Novelty: 0.02937451
p_int: 0.997235216
p_ni: 0.002764783
p_wrong: 1e-9
Score: 0.908
Data Source: BioPlex,STRINGDB
EPB41L3
Novelty: 0.00915217
p_int: 0.996128988
p_ni: 0.003871012
Score: 0.908
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (7)
Reactome (3)
PathwayCommons (3)
WikiPathways (1)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Neurexins and neuroligins | ||||
Reactome | Neuronal System | ||||
Reactome | Protein-protein interactions at synapses | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Neurexins and neuroligins | ||||
Neuronal System | ||||
Protein-protein interactions at synapses | ||||
Viral Interactions (0)
Gene Ontology Terms (27)
Functions (8)
Components (10)
Processes (9)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Inferred from Mutant Phenotype (IMP) | CAFA | |||
Traceable Author Statement (TAS) | BHF-UCL | |||
Traceable Author Statement (TAS) | ProtInc | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 1 | 3 | 3 | 97 | |||||
mean platelet volume | 3 | 3 | 3 | 95 | |||||
mean corpuscular volume | 1 | 2 | 2 | 94.5 | |||||
reticulocyte measurement | 2 | 1 | 2 | 76.7 | |||||
reticulocyte count | 2 | 1 | 2 | 75.9 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean reticulocyte volume | 3 | 97 | |||||
mean platelet volume | 3 | 95 | |||||
mean corpuscular volume | 2 | 94.5 | |||||
reticulocyte measurement | 2 | 76.7 | |||||
reticulocyte count | 2 | 75.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | erythrocyte membrane protein band 4.1 | VGNC:8911 | 456689 | |||||
Mouse | MGI:95401 | 269587 | ||||||
Dog | erythrocyte membrane protein band 4.1 | VGNC:40392 | 442955 | |||||
Horse | erythrocyte membrane protein band 4.1 | VGNC:17608 | 100056416 | |||||
Cow | erythrocyte membrane protein band 4.1 | VGNC:28519 | 281753 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | erythrocyte membrane protein band 4.1 | |||||
Mouse | ||||||
Dog | erythrocyte membrane protein band 4.1 | |||||
Horse | erythrocyte membrane protein band 4.1 | |||||
Cow | erythrocyte membrane protein band 4.1 | |||||
Publication Statistics
PubMed Score 741.85
PubMed score by year
PubTator Score 572.46
PubTator score by year
Related Publications
Text Mined References (110)
GeneRif Annotations (58)
Items per page:
0 of 0
PMID | Year | Title |
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