Tbio EPB41 Protein 4.1

Protein Summary

Description

Protein 4.1 is a major structural element of the erythrocyte membrane skeleton. It plays a key role in regulating membrane physical properties of mechanical stability and deformability by stabilizing spectrin-actin interaction. Recruits DLG1 to membranes. Required for dynein-dynactin complex and NUMA1 recruitment at the mitotic cell cortex during anaphase (PubMed:23870127). The protein encoded by this gene, together with spectrin and actin, constitute the red cell membrane cytoskeletal network. This complex plays a critical role in erythrocyte shape and deformability. Mutations in this gene are associated with type 1 elliptocytosis (EL1). Alternatively spliced transcript variants encoding different isoforms have been described for this gene.[provided by RefSeq, Oct 2009]

Uniprot Accession IDs

• P11171
• B1ALH8
• B1ALH9
• D3DPM9
• D3DPN0
• P11176
• Q14245
• Q5TB35
• Q5VXN8
• Q8IXV9
• Q9Y578
• Q9Y579
• P4.1

Gene Name

• EPB41

Ensembl ID

• ENST00000343067
• ENSP00000345259
• ENSG00000159023
• ENST00000347529
• ENSP00000290100
• ENST00000373797
• ENSP00000362903
• ENST00000373798
• ENSP00000362904
• ENST00000373800
• ENSP00000362906
• ENST00000642260
• ENSP00000495565

Symbol

• E41P
• HE
• EL1
• 4.1R

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
protein domain	1
kinase perturbation	0.97
transcription factor	0.94
hub protein	0.92
interacting protein	0.88

Protein Classes

DTO Classes

Zinc Finger Protein 491

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.82   (req: < 5)

Gene RIFs: 63   (req: <= 3)

Antibodies: 324   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 787.82   (req: >= 5)

Gene RIFs: 63   (req: > 3)

Antibodies: 324   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0