Tchem SLC2A3 Solute carrier family 2, facilitated glucose transporter member 3

Protein Summary

Description

Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).

Uniprot Accession IDs

• P11169
• B2R606
• D3DUU6
• Q6I9U2
• Q9UG15

Gene Name

• SLC2A3

Ensembl ID

• ENST00000075120
• ENSP00000075120
• ENSG00000059804

Symbol

• GLUT3
• GLUT3

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
PubMedID	1
transcription factor perturbation	1
gene perturbation	0.96
microRNA	0.82
disease perturbation	0.79

Protein Classes

DTO Classes

Protein / Transporter / Slc Superfamily Of Solute Carriers / Slc2 Family Of Hexose And Sugar Alcohol Transporters / Class I Transporters / Solute Carrier Family 2, Facilitated Glucose Transporter Member 3

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.99   (req: < 5)

Gene RIFs: 109   (req: <= 3)

Antibodies: 308   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 464.99   (req: >= 5)

Gene RIFs: 109   (req: > 3)

Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 75

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0