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Tchem
SLC2A3
Solute carrier family 2, facilitated glucose transporter member 3

Protein Summary
Description
Facilitative glucose transporter that can also mediate the uptake of various other monosaccharides across the cell membrane (PubMed:9477959, PubMed:26176916). Mediates the uptake of glucose, 2-deoxyglucose, galactose, mannose, xylose and fucose, and probably also dehydroascorbate (PubMed:9477959, PubMed:26176916). Does not mediate fructose transport (PubMed:9477959, PubMed:26176916).
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000075120
  • ENSP00000075120
  • ENSG00000059804

Symbol
  • GLUT3
  • GLUT3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
transcription factor perturbation
1
gene perturbation
0.96
microRNA
0.82
disease perturbation
0.79


Related Tools
RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.39   (req: < 5)
Gene RIFs: 74   (req: <= 3)
Antibodies: 308   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 397.39   (req: >= 5)
Gene RIFs: 74   (req: > 3)
Antibodies: 308   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 37
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Active Ligands (37)
1 – 10 of 37
CHEMBL3780470
chemical structure image
CHEMBL3781347
chemical structure image
CHEMBL3780772
chemical structure image
CHEMBL3781835
chemical structure image
CHEMBL3780717
chemical structure image
CHEMBL3780372
chemical structure image
CHEMBL3781149
chemical structure image
CHEMBL3781331
chemical structure image
CHEMBL3781913
chemical structure image
CHEMBL3780729
chemical structure image
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 3
VGNC:13447
451818
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 3
Protein Structure (4 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11169-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 4 of 4
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (22)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Gene expression (Transcription)
Generic Transcription Pathway
Immune System
Innate Immune System
Protein-Protein Interactions (191)
1 – 10 of 191
SLC2A14
Tbio
Family: Transporter
Novelty: 0.00247741
p_int: 1
Score: 0.902
Data Source: BioPlex,STRINGDB
STOM
Tbio
Novelty: 0.00459891
Score: 0.958
Data Source: STRINGDB
CLEC4C
Tbio
Novelty: 0.00845053
Score: 0.952
Data Source: STRINGDB
ITGAX
Tbio
Novelty: 0.00040471
Score: 0.92
Data Source: STRINGDB
SLC15A4
Tbio
Family: Transporter
Novelty: 0.01325014
Score: 0.916
Data Source: STRINGDB
SLC2A5
Tbio
Family: Transporter
Novelty: 0.0032733
Score: 0.912
Data Source: STRINGDB
ATP11A
Tbio
Family: Transporter
Novelty: 0.05334905
Score: 0.912
Data Source: STRINGDB
SLC11A1
Tbio
Family: Transporter
Novelty: 0.00121416
Score: 0.912
Data Source: STRINGDB
ALDH3B1
Tbio
Family: Enzyme
Novelty: 0.03330389
Score: 0.912
Data Source: STRINGDB
MCEMP1
Tdark
Novelty: 0.14180782
Score: 0.912
Data Source: STRINGDB
Publication Statistics
PubMed Score  397.39

PubMed score by year
PubTator Score  260.25

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer