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Tchem
SLC2A2
Solute carrier family 2, facilitated glucose transporter member 2

Protein Summary
Description
Facilitative glucose transporter. This isoform likely mediates the bidirectional transfer of glucose across the plasma membrane of hepatocytes and is responsible for uptake of glucose by the beta cells; may comprise part of the glucose-sensing mechanism of the beta cell. May also participate with the Na(+)/glucose cotransporter in the transcellular transport of glucose in the small intestine and kidney. This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000314251
  • ENSP00000323568
  • ENSG00000163581

Symbol
  • GLUT2
  • GLUT2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.73
chemical
0.67
gene perturbation
0.67
microRNA
0.65
cell type or tissue
0.63


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 891.96   (req: < 5)
Gene RIFs: 56   (req: <= 3)
Antibodies: 428   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 891.96   (req: >= 5)
Gene RIFs: 56   (req: > 3)
Antibodies: 428   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (10)
CHEMBL3781913
Rendered image for CHEMBL3781913
CHEMBL3781331
Rendered image for CHEMBL3781331
CHEMBL3781149
Rendered image for CHEMBL3781149
CHEMBL3780372
Rendered image for CHEMBL3780372
CHEMBL3781347
Rendered image for CHEMBL3781347
CHEMBL3780470
Rendered image for CHEMBL3780470
CHEMBL3780717
Rendered image for CHEMBL3780717
CHEMBL3781835
Rendered image for CHEMBL3781835
CHEMBL3780772
Rendered image for CHEMBL3780772
CHEMBL3780756
Rendered image for CHEMBL3780756
Protein-Protein Interactions (185)
TRUB1
Tbio
Family:  Enzyme
Novelty:  0.07013834
p_int:  0.996628268
p_ni:  0.003369291
p_wrong:  0.000002441
Score:  0.54
Data Source:  BioPlex,STRINGDB
APOB
Tchem
Novelty:  0.00008247
p_int:  0.796426013
p_ni:  0.203573987
Score:  0.763
Data Source:  BioPlex,STRINGDB
HNF1A
Tbio
Family:  TF
Novelty:  0.00101291
Score:  0.952
Data Source:  STRINGDB
SLC5A1
Tclin
Family:  Transporter
Novelty:  0.00113611
Score:  0.913
Data Source:  STRINGDB
GCK
Tchem
Family:  Kinase
Novelty:  0.00112778
Score:  0.906
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.853
Data Source:  STRINGDB
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.842
Data Source:  STRINGDB
GCG
Tchem
Novelty:  0.00004879
Score:  0.814
Data Source:  STRINGDB
SLC2A1
Tchem
Family:  Transporter
Novelty:  0.00027583
Score:  0.811
Data Source:  STRINGDB
PDX1
Tbio
Family:  TF
Novelty:  0.00232117
Score:  0.809
Data Source:  STRINGDB
Pathways (45)
Cellular hexose transport (R-HSA-189200)

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Find Similar Targets
Items per page:
1 – 5 of 16
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
Reactome
Developmental Biology
Reactome
Digestion and absorption
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Defective SLC2A2 causes Fanconi-Bickel syndrome (FBS)
Developmental Biology
Digestion and absorption
Disease
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (16)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Experiment (EXP)
Reactome
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (15)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
3
3
2
4.9
97.3
glucose measurement
4
5
5
95.4
5
4
3
1.1
92.8
HbA1c measurement
5
5
6
84.8
body mass index
4
4
4
83.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
serum gamma-glutamyl transferase measurement
2
4.9
97.3
glucose measurement
5
95.4
3
1.1
92.8
HbA1c measurement
6
84.8
body mass index
4
83.9
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 2
VGNC:8009
460848
Macaque
solute carrier family 2 member 2
695538
Mouse
MGI:1095438
20526
Rat
RGD:3705
25351
Dog
solute carrier family 2 member 2
VGNC:46341
488165
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 2
Macaque
solute carrier family 2 member 2
Mouse
Rat
Dog
solute carrier family 2 member 2
Publication Statistics
PubMed Score 891.96
PubMed score by year
PubTator Score 338.94
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title