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Tchem
SLC2A1
Solute carrier family 2, facilitated glucose transporter member 1

Protein Summary
Description
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426263
  • ENSP00000416293
  • ENSG00000117394

Symbol
  • GLUT1
  • CSE
  • PED
  • DYT9
  • GLUT
  • DYT17
  • DYT18
  • EIG12
  • GLUT1
  • HTLVR
  • GLUT-1
  • SDCHCN
  • GLUT1DS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cellular component
0.98
transcription factor perturbation
0.97
chemical
0.96
interacting protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3562.45   (req: < 5)
Gene RIFs: 461   (req: <= 3)
Antibodies: 625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 3562.45   (req: >= 5)
Gene RIFs: 461   (req: > 3)
Antibodies: 625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
RESOLUTE
Thumbnail image for RESOLUTE
RESOLUTE is a public-private partnership with the goal of escalating research on solute carriers (SLCs) and to establish SLCs as a tractable target class for medical research and development.
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (126)
CHEMBL526110
Rendered image for CHEMBL526110
CHEMBL468963
Rendered image for CHEMBL468963
CHEMBL3781913
Rendered image for CHEMBL3781913
CHEMBL3781331
Rendered image for CHEMBL3781331
CHEMBL3781149
Rendered image for CHEMBL3781149
CHEMBL3780372
Rendered image for CHEMBL3780372
CHEMBL3781347
Rendered image for CHEMBL3781347
CHEMBL3780470
Rendered image for CHEMBL3780470
CHEMBL3780717
Rendered image for CHEMBL3780717
CHEMBL3781835
Rendered image for CHEMBL3781835
Protein-Protein Interactions (239)
ATP6V0A2
Tbio
Family:  Enzyme
Novelty:  0.00504614
p_int:  0.987387378
p_ni:  0.012612622
Data Source:  BioPlex
ATP6V0A1
Tbio
Family:  Enzyme
Novelty:  0.02009317
p_int:  0.959211177
p_ni:  0.040788823
Data Source:  BioPlex
ATP11C
Tbio
Family:  Transporter
Novelty:  0.05441047
p_int:  0.938923536
p_ni:  0.061076436
p_wrong:  2.8e-8
Data Source:  BioPlex
ATP6V0C
Tbio
Family:  Enzyme
Novelty:  0.01142874
p_int:  0.891584561
p_ni:  0.108415347
p_wrong:  9.2e-8
Data Source:  BioPlex
TP53
Tchem
Family:  TF
Novelty:  0.00001907
Score:  0.95
Data Source:  STRINGDB
GIPC1
Tbio
Novelty:  0.00862
Score:  0.893
Data Source:  STRINGDB
INS
Tbio
Novelty:  0.00000499
Score:  0.873
Data Source:  STRINGDB
AKT1
Tchem
Family:  Kinase
Novelty:  0.00003185
Score:  0.872
Data Source:  STRINGDB
HK2
Tchem
Family:  Kinase
Novelty:  0.00144136
Score:  0.867
Data Source:  STRINGDB
HIF1A
Tchem
Family:  TF
Novelty:  0.00011503
Score:  0.852
Data Source:  STRINGDB
Nearest Tclin Targets (3)
Explore Nearest Tclin Targets
1 – 3 of 3
THRB
Tclin
Family:  Nuclear Receptor
KEGG Distance:  2
Common Pathways:  1
Pathways (99)
Cellular hexose transport (R-HSA-189200)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular hexose transport
Reactome
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
Reactome
Disease
Reactome
Disorders of transmembrane transporters
Reactome
Integration of energy metabolism
Name
Explore in Pharos
Explore in Source
Cellular hexose transport
Defective SLC2A1 causes GLUT1 deficiency syndrome 1 (GLUT1DS1)
Disease
Disorders of transmembrane transporters
Integration of energy metabolism
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (38)
Find Similar Targets
Items per page:
10
1 – 7 of 7
GO Term
Evidence
Assigned by
Inferred from Experiment (EXP)
Reactome
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
4
4
5
96.9
mean corpuscular volume
1
2
2
94.5
mean reticulocyte volume
1
2
2
93.6
monocyte count
2
2
2
89.7
neutrophil count
2
2
2
83.6
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
5
96.9
mean corpuscular volume
2
94.5
mean reticulocyte volume
2
93.6
monocyte count
2
89.7
neutrophil count
2
83.6
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 1
VGNC:10989
100613619
Macaque
solute carrier family 2 member 1
698931
Mouse
MGI:95755
20525
Rat
RGD:3704
24778
Dog
solute carrier family 2 member 1
VGNC:46337
482437
Species
Name
OMA
EggNOG
Inparanoid
Chimp
solute carrier family 2 member 1
Macaque
solute carrier family 2 member 1
Mouse
Rat
Dog
solute carrier family 2 member 1
Publication Statistics
PubMed Score 3562.45
PubMed score by year
PubTator Score 2152.56
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title