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Tchem
SLC2A1
Solute carrier family 2, facilitated glucose transporter member 1

Protein Summary
Description
Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses. This gene encodes a major glucose transporter in the mammalian blood-brain barrier. The encoded protein is found primarily in the cell membrane and on the cell surface, where it can also function as a receptor for human T-cell leukemia virus (HTLV) I and II. Mutations in this gene have been found in a family with paroxysmal exertion-induced dyskinesia. [provided by RefSeq, Apr 2013]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000426263
  • ENSP00000416293
  • ENSG00000117394

Symbol
  • GLUT1
  • CSE
  • PED
  • DYT9
  • GLUT
  • DYT17
  • DYT18
  • EIG12
  • GLUT1
  • HTLVR
  • GLUT-1
  • SDCHCN
  • GLUT1DS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
1
cellular component
0.98
transcription factor perturbation
0.97
chemical
0.96
interacting protein
0.96


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4127.85   (req: < 5)
Gene RIFs: 461   (req: <= 3)
Antibodies: 625   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4127.85   (req: >= 5)
Gene RIFs: 461   (req: > 3)
Antibodies: 625   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 126
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0