Tbio EGR2 E3 SUMO-protein ligase EGR2

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / E3 Sumo-protein Ligase Egr2

Protein / Transcription Factor / Transcription Cofactor / E3 Sumo-protein Ligase Egr2

Protein / Nucleic Acid Binding / Dna Binding Protein / E3 Sumo-protein Ligase Egr2

DTO Classes

Protein / Nucleic Acid Binding / Dna Binding Protein / E3 Sumo-protein Ligase Egr2

Protein Summary

Description

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P11161
• B2R724
• B3KRD7
• Q68CZ5
• Q8IV26
• Q9UNA6

Gene Name

• EGR2

Ensembl ID

• ENST00000242480
• ENSP00000242480
• ENSG00000122877
• ENST00000411732
• ENSP00000387634
• ENST00000439032
• ENSP00000402040

Symbol

• KROX20
• CHN1
• AT591
• CMT1D
• CMT4E
• KROX20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
molecular function	0.99
PubMedID	0.98
biological process	0.97
virus perturbation	0.94

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.15   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 459   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.15   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

GWAS Traits (22)

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GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	2	2	0	1.3	77.7
eosinophil count	EFO_0004842	1	1	1		76.1
lymphocyte count	EFO_0004587	2	1	2		72.3
Ewing sarcoma	EFO_0000174	1	1	0	1.7	68
platelet count	EFO_0004309	1	1	1		67.7

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
Crohn's disease	EFO_0000384	0	1.3	77.7
eosinophil count	EFO_0004842	1		76.1
lymphocyte count	EFO_0004587	2		72.3
Ewing sarcoma	EFO_0000174	0	1.7	68
platelet count	EFO_0004309	1		67.7

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Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	early growth response 2	VGNC:12319	745846
Macaque	early growth response 2		698132
Mouse	early growth response 2	MGI:95296	13654
Rat	early growth response 2	RGD:621608	114090
Dog	early growth response 2	VGNC:51893	479219

Species	Name	OMA	EggNOG	Inparanoid
Chimp	early growth response 2
Macaque	early growth response 2
Mouse	early growth response 2
Rat	early growth response 2
Dog	early growth response 2

Protein Structure (0 Structures, 1 AlphaFold Model)

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Representation

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Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

AF-P11161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (48)

Reactome (4)

KEGG (4)

PathwayCommons (3)

UniProt (1)

WikiPathways (36)

Activation of HOX genes during differentiation (R-HSA-5619507)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Name	Explore in Pharos	Explore in Source
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Developmental Biology	1055 targets	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Gene Ontology Terms (38)

Functions (11)

Components (4)

Processes (23)

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GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
chromatin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
RNA polymerase II activating transcription factor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
transcription regulatory region DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
HMG box domain binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (194)

Explore Interacting Targets

1 – 10 of 194

• See Interactions on String-DB

SNAI1

Tbio

Family:  TF

Novelty:  0.00040495

p_int:  0.999998835

p_wrong:  0.000001165

Score:  0.646

Data Source:  BioPlex,STRINGDB

JUN

Tchem

Family:  TF

Novelty:  0.00006856

Score:  0.981

Data Source:  STRINGDB

HOXB1

Tbio

Family:  TF

Novelty:  0.00731831

Score:  0.977

Data Source:  STRINGDB

EGR3

Tbio

Family:  TF

Novelty:  0.00766779

Score:  0.961

Data Source:  STRINGDB

MAFB

Tbio

Family:  TF

Novelty:  0.00646074

Score:  0.96

Data Source:  STRINGDB

HOXA2

Tbio

Family:  TF

Novelty:  0.00843414

Score:  0.952

Data Source:  STRINGDB

HOXB2

Tbio

Family:  TF

Novelty:  0.015749

Score:  0.95

Data Source:  STRINGDB

HOXB3

Tbio

Family:  TF

Novelty:  0.01572964

Score:  0.945

Data Source:  STRINGDB

CEBPB

Tbio

Family:  TF

Novelty:  0.00068108

Score:  0.943

Data Source:  STRINGDB

EZH2

Tclin

Family:  Epigenetic

Novelty:  0.00052816

Score:  0.929

Data Source:  STRINGDB

Publication Statistics

PubMed Score  472.15

PubMed score by year

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PubTator Score  239.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

No Header	No Header
Activator
Alternative splicing
Charcot-Marie-Tooth disease
Complete proteome
Dejerine-Sottas syndrome
Disease mutation
DNA-binding
Metal-binding
Neurodegeneration
Neuropathy

GWAS Trait Find Similar Targets

No Header	No Header
Agents acting on the renin-angiotensin system use measurement
albuminuria
BMI-adjusted hip circumference
Crohn's disease
daytime rest measurement
diastolic blood pressure
Diuretic use measurement
eosinophil count
eosinophil percentage of leukocytes
Ewing sarcoma

MGI Phenotype Find Similar Targets

No Header	No Header
behavior/neurological phenotype
cardiovascular system phenotype
cellular phenotype
craniofacial phenotype
embryo phenotype
growth/size/body region phenotype
limbs/digits/tail phenotype
mortality/aging
muscle phenotype
nervous system phenotype