EGR2
E3 SUMO-protein ligase EGR2
Protein Summary
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- ENST00000242480
- ENSP00000242480
- ENSG00000122877
- ENST00000411732
- ENSP00000387634
- ENST00000439032
- ENSP00000402040
- KROX20
- CHN1
- AT591
- CMT1D
- CMT4E
- KROX20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
molecular function | 0.99 | ||
PubMedID | 0.98 | ||
biological process | 0.97 | ||
virus perturbation | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.98 (req: < 5)
Gene RIFs: 79 (req: <= 3)
Antibodies: 459 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 513.98 (req: >= 5)
Gene RIFs: 79 (req: > 3)
Antibodies: 459 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0