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Tbio
EGR2
E3 SUMO-protein ligase EGR2

Protein Summary
Description
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000242480
  • ENSP00000242480
  • ENSG00000122877
  • ENST00000411732
  • ENSP00000387634
  • ENST00000439032
  • ENSP00000402040

Symbol
  • KROX20
  • CHN1
  • AT591
  • CMT1D
  • CMT4E
  • KROX20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
gene perturbation
1
molecular function
0.99
PubMedID
0.98
biological process
0.97
virus perturbation
0.94


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.15   (req: < 5)
Gene RIFs: 59   (req: <= 3)
Antibodies: 459   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 472.15   (req: >= 5)
Gene RIFs: 59   (req: > 3)
Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (22)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
2
0
1.3
77.7
eosinophil count
1
1
1
76.1
lymphocyte count
2
1
2
72.3
1
1
0
1.7
68
platelet count
1
1
1
67.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
77.7
eosinophil count
1
76.1
lymphocyte count
2
72.3
0
1.7
68
platelet count
1
67.7
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
early growth response 2
VGNC:12319
745846
Macaque
early growth response 2
698132
Mouse
MGI:95296
13654
Rat
RGD:621608
114090
Dog
early growth response 2
VGNC:51893
479219
Species
Name
OMA
EggNOG
Inparanoid
Chimp
early growth response 2
Macaque
early growth response 2
Mouse
Rat
Dog
early growth response 2
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P11161-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (48)
Activation of HOX genes during differentiation (R-HSA-5619507)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of HOX genes during differentiation
Reactome
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Reactome
Developmental Biology
Reactome
Transcriptional regulation of white adipocyte differentiation
Name
Explore in Pharos
Explore in Source
Activation of HOX genes during differentiation
Activation of anterior HOX genes in hindbrain development during early embryogenesis
Developmental Biology
Transcriptional regulation of white adipocyte differentiation
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (194)
1 – 10 of 194
SNAI1
Tbio
Family:  TF
Novelty:  0.00040495
p_int:  0.999998835
p_wrong:  0.000001165
Score:  0.646
Data Source:  BioPlex,STRINGDB
JUN
Tchem
Family:  TF
Novelty:  0.00006856
Score:  0.981
Data Source:  STRINGDB
HOXB1
Tbio
Family:  TF
Novelty:  0.00731831
Score:  0.977
Data Source:  STRINGDB
EGR3
Tbio
Family:  TF
Novelty:  0.00766779
Score:  0.961
Data Source:  STRINGDB
MAFB
Tbio
Family:  TF
Novelty:  0.00646074
Score:  0.96
Data Source:  STRINGDB
HOXA2
Tbio
Family:  TF
Novelty:  0.00843414
Score:  0.952
Data Source:  STRINGDB
HOXB2
Tbio
Family:  TF
Novelty:  0.015749
Score:  0.95
Data Source:  STRINGDB
HOXB3
Tbio
Family:  TF
Novelty:  0.01572964
Score:  0.945
Data Source:  STRINGDB
CEBPB
Tbio
Family:  TF
Novelty:  0.00068108
Score:  0.943
Data Source:  STRINGDB
EZH2
Tclin
Family:  Epigenetic
Novelty:  0.00052816
Score:  0.929
Data Source:  STRINGDB
Publication Statistics
PubMed Score  472.15

PubMed score by year
PubTator Score  239.52

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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