EGR2
E3 SUMO-protein ligase EGR2
Protein Summary
Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
- ENST00000242480
- ENSP00000242480
- ENSG00000122877
- ENST00000411732
- ENSP00000387634
- ENST00000439032
- ENSP00000402040
- KROX20
- CHN1
- AT591
- CMT1D
- CMT4E
- KROX20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 1 | ||
molecular function | 0.99 | ||
PubMedID | 0.98 | ||
biological process | 0.97 | ||
virus perturbation | 0.94 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 472.15 (req: < 5)
Gene RIFs: 59 (req: <= 3)
Antibodies: 459 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 472.15 (req: >= 5)
Gene RIFs: 59 (req: > 3)
Antibodies: 459 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 34
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (194)
SNAI1
Family: TF
Novelty: 0.00040495
p_int: 0.999998835
p_wrong: 0.000001165
Score: 0.646
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (48)
Reactome (4)
KEGG (4)
PathwayCommons (3)
UniProt (1)
WikiPathways (36)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of HOX genes during differentiation | ||||
Reactome | Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Reactome | Developmental Biology | ||||
Reactome | Transcriptional regulation of white adipocyte differentiation | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of HOX genes during differentiation | ||||
Activation of anterior HOX genes in hindbrain development during early embryogenesis | ||||
Developmental Biology | ||||
Transcriptional regulation of white adipocyte differentiation | ||||
Viral Interactions (0)
Gene Ontology Terms (38)
Functions (11)
Components (4)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Direct Assay (IDA) | NTNU_SB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-KW | |||
Disease Associations (null)
GWAS Traits (22)
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
2 | 2 | 0 | 1.3 | 77.7 | |||||
eosinophil count | 1 | 1 | 1 | 76.1 | |||||
lymphocyte count | 2 | 1 | 2 | 72.3 | |||||
1 | 1 | 0 | 1.7 | 68 | |||||
platelet count | 1 | 1 | 1 | 67.7 | |||||
Items per page:
1 – 5 of 22
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
0 | 1.3 | 77.7 | |||||
eosinophil count | 1 | 76.1 | |||||
lymphocyte count | 2 | 72.3 | |||||
0 | 1.7 | 68 | |||||
platelet count | 1 | 67.7 | |||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | early growth response 2 | VGNC:12319 | 745846 | |||||
Macaque | early growth response 2 | 698132 | ||||||
Mouse | MGI:95296 | 13654 | ||||||
Rat | RGD:621608 | 114090 | ||||||
Dog | early growth response 2 | VGNC:51893 | 479219 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | early growth response 2 | |||||
Macaque | early growth response 2 | |||||
Mouse | ||||||
Rat | ||||||
Dog | early growth response 2 | |||||
Publication Statistics
PubMed Score 472.15
PubMed score by year
PubTator Score 239.52
PubTator score by year
Related Publications
Text Mined References (89)
GeneRif Annotations (59)
Items per page:
0 of 0
PMID | Year | Title |
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