Tbio EGR2 E3 SUMO-protein ligase EGR2

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Zinc Finger Transcription Factor / E3 Sumo-protein Ligase Egr2

Protein / Transcription Factor / Transcription Cofactor / E3 Sumo-protein Ligase Egr2

Protein / Nucleic Acid Binding / Dna Binding Protein / E3 Sumo-protein Ligase Egr2

Protein Summary

Description

Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 own transcriptional activity. The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]

Uniprot Accession IDs

• P11161
• B2R724
• B3KRD7
• Q68CZ5
• Q8IV26
• Q9UNA6

Gene Name

• EGR2

Ensembl ID

• ENST00000242480
• ENSP00000242480
• ENSG00000122877
• ENST00000411732
• ENSP00000387634
• ENST00000439032
• ENSP00000402040

Symbol

• KROX20
• CHN1
• AT591
• CMT1D
• CMT4E
• KROX20

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	1
molecular function	0.99
PubMedID	0.98
biological process	0.97
virus perturbation	0.94

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.21   (req: < 5)

Gene RIFs: 59   (req: <= 3)

Antibodies: 459   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 379.21   (req: >= 5)

Gene RIFs: 59   (req: > 3)

Antibodies: 459   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 34

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Pathways (48)

Reactome (4)

KEGG (4)

PathwayCommons (3)

UniProt (1)

WikiPathways (36)

Activation of HOX genes during differentiation (R-HSA-5619507)

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Items per page:

5

1 – 4 of 4

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Reactome	Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Reactome	Developmental Biology	1055 targets	R-HSA-1266738
Reactome	Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Name	Explore in Pharos	Explore in Source
Activation of HOX genes during differentiation	90 targets	R-HSA-5619507
Activation of anterior HOX genes in hindbrain development during early embryogenesis	90 targets	R-HSA-5617472
Developmental Biology	1055 targets	R-HSA-1266738
Transcriptional regulation of white adipocyte differentiation	84 targets	R-HSA-381340

Gene Ontology Terms (38)

Functions (11)

Components (4)

Processes (23)

Items per page:

10

1 – 10 of 11

GO Term	Evidence	Assigned by
DNA-binding transcription factor activity	Inferred from Direct Assay (IDA)	UniProtKB
proximal promoter DNA-binding transcription activator activity, RNA polymerase II-specific	Inferred from Direct Assay (IDA)	NTNU_SB
RNA polymerase II proximal promoter sequence-specific DNA binding	Inferred from Direct Assay (IDA)	NTNU_SB
ubiquitin protein ligase binding	Inferred from Physical Interaction (IPI)	UniProtKB
chromatin binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
RNA polymerase II activating transcription factor binding	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
transcription regulatory region DNA binding	Inferred from Sequence or structural Similarity (ISS)	UniProtKB
DNA-binding transcription factor activity, RNA polymerase II-specific	Inferred from Sequence Alignment (ISA)	NTNU_SB
HMG box domain binding	Inferred from Electronic Annotation (IEA)	Ensembl
metal ion binding	Inferred from Electronic Annotation (IEA)	UniProtKB-KW

Protein-Protein Interactions (194)

Explore Interacting Targets

1 – 10 of 194

• See Interactions on String-DB

SNAI1

Tbio

Family: TF

Novelty: 0.00045743

p_int: 0.999998835

p_wrong: 0.000001165

Score: 0.646

Data Source: BioPlex,STRINGDB

JUN

Tchem

Family: TF

Novelty: 0.00013623

Score: 0.981

Data Source: STRINGDB

HOXB1

Tbio

Family: TF

Novelty: 0.00873574

Score: 0.977

Data Source: STRINGDB

EGR3

Tbio

Family: TF

Novelty: 0.00269121

Score: 0.961

Data Source: STRINGDB

MAFB

Tbio

Family: TF

Novelty: 0.00869998

Score: 0.96

Data Source: STRINGDB

HOXA2

Tbio

Family: TF

Novelty: 0.01119905

Score: 0.952

Data Source: STRINGDB

HOXB2

Tbio

Family: TF

Novelty: 0.02193114

Score: 0.95

Data Source: STRINGDB

HOXB3

Tbio

Family: TF

Novelty: 0.02148868

Score: 0.945

Data Source: STRINGDB

CEBPB

Tbio

Family: TF

Novelty: 0.00076161

Score: 0.943

Data Source: STRINGDB

EZH2

Tclin

Family: Epigenetic

Novelty: 0.00057242

Score: 0.929

Data Source: STRINGDB

Publication Statistics

PubMed Score  379.21

PubMed score by year

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PubTator Score  239.52

PubTator score by year

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Amino Acid Sequence

Residue Counts

Sequence

MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRS

1-70

LDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSAS

70-140

PNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPS

140-210

PKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGV

210-280

TGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRR

280-350

FSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIH

350-420

LRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

420-476

MMTAKAVDKIPVTLSGFVHQLSDNIYPVEDLAATSVTIFPNAELGGPFDQMNGVAGDGMINIDMTGEKRSLDLPYPSSFAPVSAPRNQTFTYMGKFSIDPQYPGASCYPEGIINIVSAGILQGVTSPASTTASSSVTSASPNPLATGPLGVCTMSQTQPDLDHLYSPPPPPPPYSGCAGDLYQDPSAFLSAATTSTSSSLAYPPPPSYPSPKPATDPGLFPMIPDYPGFFPSQCQRDLHGTAGPDRKPFPCPLDTLRVPPPLTPLSTIRNFTLGGPSAGVTGPGASGGSEGPRLPGSSSAAAAAAAAAAYNPHHLPLRPILRPRKYPNRPSKTPVHERPYPCPAEGCDRRFSRSDELTRHIRIHTGHKPFQCRICMRNFSRSDHLTTHIRTHTGEKPFACDYCGRKFARSDERKRHTKIHLRQKERKSSAPSASVPAPSTASCSGGVQPGGTLCSSNSSSLGGGPLAPCSSRTRTP

Find similar targets by:

Uniprot Keyword

Activator
Alternative splicing
Charcot-Marie-Tooth disease
Complete proteome
Dejerine-Sottas syndrome
Disease mutation
DNA-binding
Metal-binding
Neurodegeneration
Neuropathy