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Tchem
LIPC
Hepatic triacylglycerol lipase

Protein Summary
Description
Hepatic lipase has the capacity to catalyze hydrolysis of phospholipids, mono-, di-, and triglycerides, and acyl-CoA thioesters. It is an important enzyme in HDL metabolism. Hepatic lipase binds heparin. LIPC encodes hepatic triglyceride lipase, which is expressed in liver. LIPC has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000299022
  • ENSP00000299022
  • ENSG00000166035
  • ENST00000356113
  • ENSP00000348425

Symbol
  • HTGL
  • HL
  • HTGL
  • LIPH
  • HDLCQ12
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
metabolite
1
trait
0.97
protein domain
0.92
disease
0.91
biological term
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 459.54   (req: < 5)
Gene RIFs: 160   (req: <= 3)
Antibodies: 340   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 459.54   (req: >= 5)
Gene RIFs: 160   (req: > 3)
Antibodies: 340   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 326
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
orlistat
Rendered image for orlistat
GWAS Traits (44)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
35
48
113
2.3
100
apolipoprotein A 1 measurement
2
30
31
100
total cholesterol measurement
11
29
47
2.6
99.4
triglyceride measurement
22
21
58
3.3
99.4
sleep duration
3
8
10
99.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
113
2.3
100
apolipoprotein A 1 measurement
31
100
total cholesterol measurement
47
2.6
99.4
triglyceride measurement
58
3.3
99.4
sleep duration
10
99.2
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
lipase C, hepatic type
VGNC:7536
746925
Macaque
lipase C, hepatic type
701116
Mouse
MGI:96216
15450
Rat
RGD:3009
24538
Dog
lipase C, hepatic type
VGNC:42694
478320
Species
Name
OMA
EggNOG
Inparanoid
Chimp
lipase C, hepatic type
Macaque
lipase C, hepatic type
Mouse
Rat
Dog
lipase C, hepatic type
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P11150-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (29)
Assembly of active LPL and LIPC lipase complexes (R-HSA-8963889)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Assembly of active LPL and LIPC lipase complexes
Reactome
Chylomicron clearance
Reactome
Plasma lipoprotein assembly, remodeling, and clearance
Reactome
Plasma lipoprotein clearance
Reactome
Plasma lipoprotein remodeling
Name
Explore in Pharos
Explore in Source
Assembly of active LPL and LIPC lipase complexes
Chylomicron clearance
Plasma lipoprotein assembly, remodeling, and clearance
Plasma lipoprotein clearance
Plasma lipoprotein remodeling
Gene Ontology Terms (22)
Items per page:
10
1 – 5 of 5
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Traceable Author Statement (TAS)
BHF-UCL
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Protein-Protein Interactions (179)
1 – 10 of 179
ATP4A
Tclin
Family:  Transporter
Novelty:  0.00008783
p_int:  0.999995658
p_ni:  0.000004326
p_wrong:  1.5e-8
Score:  0.288
Data Source:  BioPlex,STRINGDB
MTMR1
Tbio
Family:  Enzyme
Novelty:  0.06694505
p_int:  0.975489373
p_ni:  0.024510627
Score:  0.319
Data Source:  BioPlex,STRINGDB
APOB
Tchem
Novelty:  0.00008247
Score:  0.982
Data Source:  STRINGDB
LMF1
Tbio
Family:  Enzyme
Novelty:  0.0280811
Score:  0.98
Data Source:  Reactome,STRINGDB
APOE
Tbio
Novelty:  0.00005049
Score:  0.966
Data Source:  STRINGDB
LIPE
Tchem
Family:  Enzyme
Novelty:  0.00169872
Score:  0.963
Data Source:  STRINGDB
PNPLA3
Tbio
Family:  Enzyme
Novelty:  0.00180327
Score:  0.959
Data Source:  STRINGDB
PNPLA2
Tchem
Family:  Enzyme
Novelty:  0.00149181
Score:  0.959
Data Source:  STRINGDB
LDLR
Tchem
Novelty:  0.06585434
Score:  0.959
Data Source:  STRINGDB
MGLL
Tchem
Family:  Enzyme
Novelty:  0.00196912
Score:  0.945
Data Source:  STRINGDB
Publication Statistics
PubMed Score  459.54

PubMed score by year
PubTator Score  835.83

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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