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Tchem
HSPA8
Heat shock cognate 71 kDa protein

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227378
  • ENSP00000227378
  • ENSG00000109971
  • ENST00000453788
  • ENSP00000404372
  • ENST00000532636
  • ENSP00000437125
  • ENST00000534624
  • ENSP00000432083

Symbol
  • HSC70
  • HSP73
  • HSPA10
  • LAP1
  • HSC54
  • HSC70
  • HSC71
  • HSP71
  • HSP73
  • LAP-1
  • NIP71
  • HEL-33
  • HSPA10
  • HEL-S-72p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
1
molecular function
1
virus perturbation
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1163.12   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 1027   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1163.12   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 1027   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
1
1
50.7
myeloid white cell count
1
1
1
40.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
red blood cell distribution width
1
50.7
myeloid white cell count
1
40.5
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 8
VGNC:11823
451629
Macaque
heat shock protein family A (Hsp70) member 8
707989
Mouse
MGI:105384
15481
Rat
RGD:621725
24468
Dog
heat shock protein family A (Hsp70) member 8
479406
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 8
Macaque
heat shock protein family A (Hsp70) member 8
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 8
Protein Structure (37 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11142-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 37
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (62)
AUF1 (hnRNP D0) binds and destabilizes mRNA (R-HSA-450408)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 40
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
AUF1 (hnRNP D0) binds and destabilizes mRNA
Reactome
Attenuation phase
Reactome
Autophagy
Reactome
Axon guidance
Reactome
CHL1 interactions
Name
Explore in Pharos
Explore in Source
AUF1 (hnRNP D0) binds and destabilizes mRNA
Attenuation phase
Autophagy
Axon guidance
CHL1 interactions
Gene Ontology Terms (89)
Items per page:
10
1 – 10 of 18
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ParkinsonsUK-UCL
Protein-Protein Interactions (1068)
1 – 10 of 1068
HSF2
Tbio
Family: TF
Novelty: 0.06458223
p_int: 0.999997478
p_ni: 0.000002522
Score: 0.524
Data Source: BioPlex,STRINGDB
CD207
Tbio
Novelty: 0.00313729
p_int: 0.999997434
p_ni: 0.000002554
p_wrong: 1.2e-8
Score: 0.151
Data Source: BioPlex,STRINGDB
ARMC1
Tbio
Novelty: 0.02018109
p_int: 0.999989234
p_ni: 0.000010766
Data Source: BioPlex
HSF1
Tchem
Family: TF
Novelty: 0.00450276
p_int: 0.99998756
p_ni: 0.000012437
p_wrong: 3e-9
Score: 0.983
Data Source: BioPlex,Reactome,STRINGDB
METTL21A
Tbio
Family: Enzyme
Novelty: 0.31897774
p_int: 0.999980016
p_ni: 0.000019984
Score: 0.956
Data Source: BioPlex,Reactome,STRINGDB
ABL2
Tchem
Family: Kinase
Novelty: 0.00952983
p_int: 0.999954485
p_ni: 0.000045368
p_wrong: 1.46e-7
Score: 0.294
Data Source: BioPlex,STRINGDB
EDRF1
Tbio
Novelty: 0.24333657
p_int: 0.999947181
p_ni: 0.000052819
Data Source: BioPlex
CCDC117
Tdark
Novelty: 1.11966553
p_int: 0.999934759
p_ni: 0.000065241
Score: 0.154
Data Source: BioPlex,STRINGDB
PDPK1
Tchem
Family: Kinase
Novelty: 0.00430458
p_int: 0.99987861
p_ni: 0.00012139
Score: 0.183
Data Source: BioPlex,STRINGDB
DNAJC13
Tbio
Novelty: 0.03251995
p_int: 0.999854637
p_ni: 0.000145363
Score: 0.745
Data Source: BioPlex,STRINGDB
Publication Statistics
PubMed Score  1163.12

PubMed score by year
PubTator Score  652.13

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer