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Tchem
HSPA8
Heat shock cognate 71 kDa protein

Protein Summary
Description
Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones (PubMed:21150129, PubMed:21148293, PubMed:24732912, PubMed:27916661, PubMed:23018488). The co-chaperones have been shown to not only regulate different steps of the ATPase cycle of HSP70, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may pr ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000227378
  • ENSP00000227378
  • ENSG00000109971
  • ENST00000453788
  • ENSP00000404372
  • ENST00000532636
  • ENSP00000437125
  • ENST00000534624
  • ENSP00000432083

Symbol
  • HSC70
  • HSP73
  • HSPA10
  • LAP1
  • HSC54
  • HSC70
  • HSC71
  • HSP71
  • HSP73
  • LAP-1
  • NIP71
  • HEL-33
  • HSPA10
  • HEL-S-72p
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
hub protein
1
interacting protein
1
kinase perturbation
1
molecular function
1
virus perturbation
1


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.88   (req: < 5)
Gene RIFs: 132   (req: <= 3)
Antibodies: 1027   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1290.88   (req: >= 5)
Gene RIFs: 132   (req: > 3)
Antibodies: 1027   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 51
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 9
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0