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Tbio
ACP2
Lysosomal acid phosphatase

Protein Summary
Description
The protein encoded by this gene belongs to the histidine acid phosphatase family, which hydrolyze orthophosphoric monoesters to alcohol and phosphate. This protein is localized to the lysosomal membrane, and is chemically and genetically distinct from the red cell acid phosphatase. Mice lacking this gene showed multiple defects, including bone structure alterations, lysosomal storage defects, and an increased tendency towards seizures. An enzymatically-inactive allele of this gene in mice showed severe growth retardation, hair-follicle abnormalities, and an ataxia-like phenotype. Alternatively spliced transcript variants have been found for this gene. A C-terminally extended isoform is also predicted to be produced by the use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism. [provided by RefSeq, Oct 2017]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000256997
  • ENSP00000256997
  • ENSG00000134575

Symbol
  • LAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
0.99
disease perturbation
0.96
transcription factor binding site profile
0.9
cellular component
0.88
histone modification site profile
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.69   (req: < 5)
Gene RIFs: 7   (req: <= 3)
Antibodies: 102   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 275.69   (req: >= 5)
Gene RIFs: 7   (req: > 3)
Antibodies: 102   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (89)
EVA1B
Tdark
Novelty:  2.1380272
p_int:  0.999376565
p_ni:  0.000623435
Data Source:  BioPlex
S1PR1
Tclin
Family:  GPCR
Novelty:  0.00162513
p_int:  0.99610015
p_ni:  0.00389985
Data Source:  BioPlex
LGALS8
Tchem
Novelty:  0.00623836
p_int:  0.994827726
p_ni:  0.005172273
Score:  0.162
Data Source:  BioPlex,STRINGDB
LMAN2L
Tbio
Novelty:  0.04364985
p_int:  0.992791621
p_ni:  0.00720836
p_wrong:  1.8e-8
Score:  0.204
Data Source:  BioPlex,STRINGDB
LGALS3
Tchem
Novelty:  0.00032754
p_int:  0.984881712
p_ni:  0.015118182
p_wrong:  1.05e-7
Score:  0.214
Data Source:  BioPlex,STRINGDB
HTR2C
Tclin
Family:  GPCR
Novelty:  0.00074287
p_int:  0.978977689
p_ni:  0.021022311
p_wrong:  1e-9
Data Source:  BioPlex
LPAR1
Tchem
Family:  GPCR
Novelty:  0.00318056
p_int:  0.977985694
p_ni:  0.022014306
Data Source:  BioPlex
P2RY12
Tclin
Family:  GPCR
Novelty:  0.00035406
p_int:  0.969291883
p_ni:  0.030708116
p_wrong:  1e-9
Data Source:  BioPlex
LGALS9
Tchem
Novelty:  0.00381766
p_int:  0.961388879
p_ni:  0.038604581
p_wrong:  0.000006541
Data Source:  BioPlex
ADGRG5
Tdark
Family:  GPCR
Novelty:  0.26575982
p_int:  0.955218582
p_ni:  0.044781418
Data Source:  BioPlex
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (3)
Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
KEGG
Lysosome
KEGG
Riboflavin metabolism
KEGG
Metabolic pathways
Name
Explore in Pharos
Explore in Source
Lysosome
Riboflavin metabolism
Metabolic pathways
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (46)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
12
18
30
99.6
apolipoprotein A 1 measurement
2
6
7
98.3
triglyceride measurement
4
8
8
96
IGF-1 measurement
1
5
5
95.2
glucose measurement
3
6
6
95.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
30
99.6
apolipoprotein A 1 measurement
7
98.3
triglyceride measurement
8
96
IGF-1 measurement
5
95.2
glucose measurement
6
95.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 2, lysosomal
VGNC:7794
451166
Macaque
acid phosphatase 2, lysosomal
713744
Mouse
MGI:87882
11432
Rat
RGD:2021
24162
Dog
acid phosphatase 2, lysosomal
VGNC:51839
475983
Species
Name
OMA
EggNOG
Inparanoid
Chimp
acid phosphatase 2, lysosomal
Macaque
acid phosphatase 2, lysosomal
Mouse
Rat
Dog
acid phosphatase 2, lysosomal
Publication Statistics
PubMed Score 275.69
PubMed score by year
PubTator Score 54.13
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title