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Tchem
PNMT
Phenylethanolamine N-methyltransferase

Protein Summary
Description
Converts noradrenaline to adrenaline. The product of this gene catalyzes the last step of the catecholamine biosynthesis pathway, which methylates norepinephrine to form epinephrine (adrenaline). The enzyme also has beta-carboline 2N-methyltransferase activity. This gene is thought to play a key step in regulating epinephrine production. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Nov 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000269582
  • ENSP00000269582
  • ENSG00000141744

Symbol
  • PENT
  • PENT
  • PNMTase
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.76
virus perturbation
0.76
drug
0.7
cell type or tissue
0.69
disease
0.64


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 631.53   (req: < 5)
Gene RIFs: 25   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 631.53   (req: >= 5)
Gene RIFs: 25   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 3
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 71
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (71)
LY134046
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CHEMBL290890
Rendered image for CHEMBL290890
CHEMBL286497
Rendered image for CHEMBL286497
CHEMBL176112
Rendered image for CHEMBL176112
CHEMBL355581
Rendered image for CHEMBL355581
CHEMBL337144
Rendered image for CHEMBL337144
CHEMBL41487
Rendered image for CHEMBL41487
CHEMBL57966
Rendered image for CHEMBL57966
Protein-Protein Interactions (56)
ESR1
Tclin
Family:  NR
Novelty:  0.00005938
p_int:  0.929202421
p_ni:  0.042326228
p_wrong:  0.028471351
Score:  0.555
Data Source:  BioPlex,STRINGDB
DBH
Tchem
Family:  Enzyme
Novelty:  0.00074741
Score:  0.99
Data Source:  STRINGDB
COMT
Tclin
Family:  Enzyme
Novelty:  0.00025107
Score:  0.96
Data Source:  STRINGDB
MAOA
Tclin
Family:  Enzyme
Novelty:  0.00031037
Score:  0.947
Data Source:  STRINGDB
MAOB
Tclin
Family:  Enzyme
Novelty:  0.00030366
Score:  0.946
Data Source:  STRINGDB
Q8WZ04
Tbio
Family:  Enzyme
Novelty:  0.04036751
Score:  0.904
Data Source:  STRINGDB
Q96E66
Tbio
Novelty:  0.04036751
Score:  0.904
Data Source:  STRINGDB
TH
Tclin
Family:  Enzyme
Novelty:  0.00025719
Score:  0.89
Data Source:  STRINGDB
ZNF347
Tdark
Family:  TF
Novelty:  0.22263491
Score:  0.831
Data Source:  STRINGDB
EN2
Tbio
Family:  TF
Novelty:  0.00466947
Score:  0.753
Data Source:  STRINGDB
Nearest Tclin Targets (5)
Explore Nearest Tclin Targets
1 – 3 of 3
COMT
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
MAOB
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
MAOA
Tclin
Family:  Enzyme
KEGG Distance:  1
Common Pathways:  2
Pathways (34)
Catecholamine biosynthesis (R-HSA-209905)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Catecholamine biosynthesis
Reactome
Metabolism
Reactome
Metabolism of amine-derived hormones
Reactome
Metabolism of amino acids and derivatives
Name
Explore in Pharos
Explore in Source
Catecholamine biosynthesis
Metabolism
Metabolism of amine-derived hormones
Metabolism of amino acids and derivatives
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
10
9
18
98.1
7
6
0
1.2
95.1
alkaline phosphatase measurement
2
2
1
11.6
93.4
apolipoprotein A 1 measurement
1
1
1
81.2
glomerular filtration rate
1
1
1
79
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
18
98.1
0
1.2
95.1
alkaline phosphatase measurement
1
11.6
93.4
apolipoprotein A 1 measurement
1
81.2
glomerular filtration rate
1
79
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
phenylethanolamine N-methyltransferase
VGNC:9531
454634
Mouse
MGI:97724
18948
Rat
RGD:3361
24661
Dog
phenylethanolamine N-methyltransferase
VGNC:49943
491023
Horse
phenylethanolamine N-methyltransferase
VGNC:21629
100033859
Species
Name
OMA
EggNOG
Inparanoid
Chimp
phenylethanolamine N-methyltransferase
Mouse
Rat
Dog
phenylethanolamine N-methyltransferase
Horse
phenylethanolamine N-methyltransferase
Publication Statistics
PubMed Score 631.53
PubMed score by year
PubTator Score 330.82
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title