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Tbio
LAMC1
Laminin subunit gamma-1

Protein Summary
Description
Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), have a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000258341
  • ENSP00000258341
  • ENSG00000135862

Symbol
  • LAMB2
  • LAMB2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.95
transcription factor binding site profile
0.94
PubMedID
0.9
protein domain
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.82   (req: < 5)
Gene RIFs: 45   (req: <= 3)
Antibodies: 469   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 77.82   (req: >= 5)
Gene RIFs: 45   (req: > 3)
Antibodies: 469   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (11)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
3
0
1.1
97
Fuchs endothelial corneal dystrophy
1
1
0
1.4
82.7
1
1
0
1.1
72.6
1
1
1
48.1
diastolic blood pressure
1
1
1
26.8
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.1
97
Fuchs endothelial corneal dystrophy
0
1.4
82.7
0
1.1
72.6
1
48.1
diastolic blood pressure
1
26.8
Orthologs (15)
1 – 5 of 15
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
laminin subunit gamma 1
VGNC:6903
457570
Macaque
laminin subunit gamma 1
715265
Mouse
MGI:99914
226519
Rat
RGD:621052
117036
Dog
laminin subunit gamma 1
VGNC:42571
480034
Species
Name
OMA
EggNOG
Inparanoid
Chimp
laminin subunit gamma 1
Macaque
laminin subunit gamma 1
Mouse
Rat
Dog
laminin subunit gamma 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11047-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (42)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 17
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Degradation of the extracellular matrix
Reactome
Developmental Biology
Reactome
ECM proteoglycans
Reactome
Extracellular matrix organization
Name
Explore in Pharos
Explore in Source
Axon guidance
Degradation of the extracellular matrix
Developmental Biology
ECM proteoglycans
Extracellular matrix organization
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
HGNC
Protein-Protein Interactions (223)
1 – 10 of 223
FAM9C
Tdark
Novelty: 0.86727989
p_int: 0.994922403
p_ni: 0.005077597
Data Source: BioPlex
ABRAXAS2
Tbio
Novelty: 0.20430604
p_int: 0.960894779
p_ni: 0.039105221
Score: 0.2
Data Source: BioPlex,STRINGDB
TXLNB
Tbio
Novelty: 0.12751933
p_int: 0.951873511
p_ni: 0.048126489
Score: 0.188
Data Source: BioPlex,STRINGDB
CLEC11A
Tbio
Novelty: 0.03060601
p_int: 0.937981661
p_ni: 0.062018339
Score: 0.181
Data Source: BioPlex,STRINGDB
TGFB1
Tchem
Novelty: 0.0001299
p_int: 0.904102275
p_ni: 0.095897725
Score: 0.426
Data Source: BioPlex,STRINGDB
ABRAXAS1
Tbio
Novelty: 0.07078408
p_int: 0.848421637
p_ni: 0.151578363
Score: 0.309
Data Source: BioPlex,STRINGDB
PNLIP
Tclin
Family: Enzyme
Novelty: 0.00043254
p_int: 0.75985577
p_ni: 0.24014423
Score: 0.214
Data Source: BioPlex,STRINGDB
NID1
Tbio
Novelty: 0.00169075
Score: 0.995
Data Source: STRINGDB
LAMA5
Tbio
Novelty: 0.02247145
Score: 0.995
Data Source: Reactome,STRINGDB
LAMB1
Tbio
Novelty: 0.0104285
Score: 0.992
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  77.82

PubMed score by year
PubTator Score  46.1

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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