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Tchem
HSPA5
Endoplasmic reticulum chaperone BiP

Protein Summary
Description
Endoplasmic reticulum chaperone that plays a key role in protein folding and quality control in the endoplasmic reticulum lumen (PubMed:2294010, PubMed:23769672, PubMed:23990668, PubMed:28332555). Involved in the correct folding of proteins and degradation of misfolded proteins via its interaction with DNAJC10/ERdj5, probably to facilitate the release of DNAJC10/ERdj5 from its substrate (By similarity). Acts as a key repressor of the ERN1/IRE1-mediated unfolded protein response (UPR) (PubMed:1550958, PubMed:19538957). In the unstressed endoplasmic reticulum, recruited by DNAJB9/ERdj4 to the luminal region of ERN1/IRE1, leading to disrupt the dimerization of ERN1/IRE1, thereby inactivating ERN1/IRE1 (By similarity). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP from ERN1/IRE1, allowing homodimerization and subsequent activation of ERN1/IRE1 (By similarity). Plays an auxiliary role in post-translational transport of small presecretory proteins ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324460
  • ENSP00000324173
  • ENSG00000044574

Symbol
  • GRP78
  • BIP
  • MIF2
  • GRP78
  • HEL-S-89n
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
chemical
1
disease perturbation
1
hub protein
1
interacting protein
1
molecular function
1


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2634.13   (req: < 5)
Gene RIFs: 403   (req: <= 3)
Antibodies: 1556   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2634.13   (req: >= 5)
Gene RIFs: 403   (req: > 3)
Antibodies: 1556   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 58
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (8)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
67.8
smoking cessation
2
1
2
65.9
worry measurement
1
1
0
6.1
35
cigarettes per day measurement
1
1
1
24.5
neuroticism measurement
1
1
1
11.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
67.8
smoking cessation
2
65.9
worry measurement
0
6.1
35
cigarettes per day measurement
1
24.5
neuroticism measurement
1
11.1
Orthologs (17)
1 – 5 of 17
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 5
VGNC:4760
464733
Macaque
heat shock protein family A (Hsp70) member 5
703193
Mouse
MGI:95835
14828
Rat
RGD:2843
25617
Dog
heat shock protein family A (Hsp70) member 5
480726
Species
Name
OMA
EggNOG
Inparanoid
Chimp
heat shock protein family A (Hsp70) member 5
Macaque
heat shock protein family A (Hsp70) member 5
Mouse
Rat
Dog
heat shock protein family A (Hsp70) member 5
Protein Structure (16 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P11021-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 16
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (34)
ATF6 (ATF6-alpha) activates chaperone genes (R-HSA-381183)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 18
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
ATF6 (ATF6-alpha) activates chaperone genes
Reactome
ATF6 (ATF6-alpha) activates chaperones
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Cellular response to heat stress
Name
Explore in Pharos
Explore in Source
ATF6 (ATF6-alpha) activates chaperone genes
ATF6 (ATF6-alpha) activates chaperones
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Cellular response to heat stress
Gene Ontology Terms (77)
Items per page:
10
1 – 10 of 14
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
AgBase
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Protein-Protein Interactions (734)
1 – 10 of 734
FUT7
Tchem
Family:  Enzyme
Novelty:  0.01257357
p_int:  0.98907021
p_ni:  0.01092979
Data Source:  BioPlex
OLFML2B
Tbio
Novelty:  0.19222155
p_int:  0.988169196
p_ni:  0.011830804
Data Source:  BioPlex
PATE1
Tbio
Novelty:  0.0705075
p_int:  0.983280882
p_ni:  0.016719118
Data Source:  BioPlex
VIT
Tbio
Novelty:  0.13376369
p_int:  0.982697951
p_ni:  0.017302049
Score:  0.194
Data Source:  BioPlex,STRINGDB
GAL
Tbio
Novelty:  0.0005132
p_int:  0.982334773
p_ni:  0.017665227
Data Source:  BioPlex
SPAG11B
Tbio
Novelty:  0.07935181
p_int:  0.981672421
p_ni:  0.018327579
Data Source:  BioPlex
ANGPTL2
Tbio
Novelty:  0.01134724
p_int:  0.980932022
p_ni:  0.019067978
Score:  0.177
Data Source:  BioPlex,STRINGDB
PODN
Tbio
Novelty:  0.01466791
p_int:  0.978805073
p_ni:  0.021194927
Data Source:  BioPlex
PRSS1
Tclin
Family:  Enzyme
Novelty:  0.00157396
p_int:  0.974112244
p_ni:  0.025887756
Score:  0.166
Data Source:  BioPlex,STRINGDB
NTF3
Tbio
Novelty:  0.00089023
p_int:  0.973868514
p_ni:  0.026131486
Data Source:  BioPlex
Publication Statistics
PubMed Score  2634.13

PubMed score by year
PubTator Score  1622.86

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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