You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
IAPP
Islet amyloid polypeptide

Protein Summary
Description
Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. This gene encodes a member of the calcitonin family of peptide hormones. This hormone is released from pancreatic beta cells following food intake to regulate blood glucose levels and act as a satiation signal. Human patients with type 1 and advanced type 2 diabetes exhibit reduced levels of the encoded hormone in blood and pancreas. This protein also exhibits a bactericidal, antimicrobial activity. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000240652
  • ENSP00000240652
  • ENSG00000121351
  • ENST00000539393
  • ENSP00000437357

Symbol
  • DAP
  • IAP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
0.98
protein domain
0.73
cell line
0.62
gene perturbation
0.62
disease
0.51


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2189.48   (req: < 5)
Gene RIFs: 244   (req: <= 3)
Antibodies: 414   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2189.48   (req: >= 5)
Gene RIFs: 244   (req: > 3)
Antibodies: 414   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 32
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
islet amyloid polypeptide
VGNC:8421
741937
Macaque
islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329]
Mouse
MGI:96382
15874
Rat
RGD:2854
24476
Dog
islet amyloid polypeptide
VGNC:41848
403909
Species
Name
OMA
EggNOG
Inparanoid
Chimp
islet amyloid polypeptide
Macaque
islet amyloid polypeptide [Source:HGNC Symbol;Acc:HGNC:5329]
Mouse
Rat
Dog
islet amyloid polypeptide
Protein Structure (18 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10997-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 18
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (14)
Amyloid fiber formation (R-HSA-977225)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 12
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Amyloid fiber formation
Reactome
Calcitonin-like ligand receptors
Reactome
Class B/2 (Secretin family receptors)
Reactome
Developmental Biology
Reactome
G alpha (s) signalling events
Name
Explore in Pharos
Explore in Source
Amyloid fiber formation
Calcitonin-like ligand receptors
Class B/2 (Secretin family receptors)
Developmental Biology
G alpha (s) signalling events
Protein-Protein Interactions (193)
1 – 10 of 193
RAMP3
Tclin
Novelty: 0.01616194
Score: 0.987
Data Source: Reactome,STRINGDB
RAMP2
Tclin
Novelty: 0.01086538
Score: 0.986
Data Source: Reactome,STRINGDB
RAMP1
Tclin
Novelty: 0.00831253
Score: 0.986
Data Source: Reactome,STRINGDB
CALCA
Tclin
Novelty: 0.00010496
Score: 0.985
Data Source: STRINGDB
CALCA
Tbio
Novelty: 0.00010496
Score: 0.985
Data Source: STRINGDB
GCG
Tchem
Novelty: 0.00004879
Score: 0.984
Data Source: STRINGDB
ADM
Tbio
Novelty: 0.0004958
Score: 0.983
Data Source: STRINGDB
CALCB
Tclin
Novelty: 0.02069808
Score: 0.982
Data Source: STRINGDB
CALCR
Tclin
Family: GPCR
Novelty: 0.00112487
Score: 0.975
Data Source: Reactome,STRINGDB
PDX1
Tbio
Family: TF
Novelty: 0.00232117
Score: 0.973
Data Source: STRINGDB
Publication Statistics
PubMed Score  2189.48

PubMed score by year
PubTator Score  1495.71

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
Find similar targets by: