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Tbio
CD8B
T-cell surface glycoprotein CD8 beta chain

Protein Summary
Description
Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. A palmitoylation site in the cytoplasmic tail of CD8B chain contributes to partitioning of CD8 into the plasma membrane lipid rafts where signaling proteins are enriched. Once LCK recruited, it initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). A ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000331469
  • ENSP00000331172
  • ENSG00000172116
  • ENST00000349455
  • ENSP00000340592
  • ENST00000390655
  • ENSP00000375070
  • ENST00000393759
  • ENSP00000377356
  • ENST00000393761
  • ENSP00000377358

Symbol
  • CD8B1
  • LY3
  • P37
  • LEU2
  • LYT3
  • CD8B1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
co-expressed gene
0.82
gene perturbation
0.67
cell type or tissue
0.66
cellular component
0.65
tissue sample
0.6


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.37   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 822   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 227.37   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 822   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
1
1
0
1.3
45.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
Progressive supranuclear palsy
0
1.3
45.2
Orthologs (8)
1 – 5 of 8
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD8b molecule
VGNC:10544
470426
Macaque
CD8b molecule
699409
Mouse
MGI:88347
12526
Rat
RGD:2317
24931
Dog
CD8b molecule
483076
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD8b molecule
Macaque
CD8b molecule
Mouse
Rat
Dog
CD8b molecule
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10966-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (35)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Disease
Reactome
HIV Infection
Reactome
Host Interactions of HIV factors
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Disease
HIV Infection
Host Interactions of HIV factors
Immune System
Gene Ontology Terms (13)
Items per page:
10
1 – 2 of 2
GO Term
Evidence
Assigned by
Non-traceable Author Statement (NAS)
UniProtKB
Non-traceable Author Statement (NAS)
UniProtKB
Protein-Protein Interactions (155)
1 – 10 of 155
TMEM11
Tbio
Novelty: 0.00067837
p_int: 0.998882606
p_ni: 0.00111738
p_wrong: 1.5e-8
Data Source: BioPlex
TMEM214
Tdark
Novelty: 0.32604613
p_int: 0.993858641
p_ni: 0.006141359
Data Source: BioPlex
ANKRD13D
Tdark
Novelty: 2.14380936
p_int: 0.984091696
p_ni: 0.015866485
p_wrong: 0.00004182
Data Source: BioPlex
ATP6V0A2
Tbio
Family: Enzyme
Novelty: 0.00504614
p_int: 0.923926453
p_ni: 0.076073547
Data Source: BioPlex
TMED8
Tdark
Novelty: 1.41977071
p_int: 0.919084595
p_ni: 0.080887386
p_wrong: 0.000028019
Data Source: BioPlex
KLRG2
Tdark
Novelty: 1.19446694
p_int: 0.89862094
p_ni: 0.101378893
p_wrong: 1.67e-7
Data Source: BioPlex
ERGIC2
Tbio
Novelty: 0.08610944
p_int: 0.89464607
p_ni: 0.105331244
p_wrong: 0.000022686
Data Source: BioPlex
CD8A
Tbio
Novelty: 0.00002519
Score: 0.996
Data Source: Reactome,STRINGDB
CD3D
Tclin
Novelty: 0.00510314
Score: 0.987
Data Source: Reactome,STRINGDB
B2M
Tbio
Novelty: 0.00011248
Score: 0.98
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  227.37

PubMed score by year
PubTator Score  117.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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