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Tbio
MYL2
Myosin regulatory light chain 2, ventricular/cardiac muscle isoform

Protein Summary
Description
Contractile protein that plays a role in heart development and function (By similarity). Following phosphorylation, plays a role in cross-bridge cycling kinetics and cardiac muscle contraction by increasing myosin lever arm stiffness and promoting myosin head diffusion; as a consequence of the increase in maximum contraction force and calcium sensitivity of contraction force. These events altogether slow down myosin kinetics and prolong duty cycle resulting in accumulated myosins being cooperatively recruited to actin binding sites to sustain thin filament activation as a means to fine-tune myofilament calcium sensitivity to force (By similarity). During cardiogenesis plays an early role in cardiac contractility by promoting cardiac myofibril assembly (By similarity). Thus gene encodes the regulatory light chain associated with cardiac myosin beta (or slow) heavy chain. Ca+ triggers the phosphorylation of regulatory light chain that in turn triggers contraction. Mutations in this gene ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000228841
  • ENSP00000228841
  • ENSG00000111245

Symbol
  • MLC2
  • MLC2
  • CMH10
  • MLC-2s/v
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
0.83
gene perturbation
0.63
pathway
0.6
tissue
0.6
disease
0.59


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.34   (req: < 5)
Gene RIFs: 43   (req: <= 3)
Antibodies: 343   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 478.34   (req: >= 5)
Gene RIFs: 43   (req: > 3)
Antibodies: 343   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 17
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (4)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
1
1
0
1.3
76.6
urate measurement
1
1
1
70.3
neutrophil count
1
1
1
45.4
leukocyte count
1
1
1
32
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.3
76.6
urate measurement
1
70.3
neutrophil count
1
45.4
leukocyte count
1
32
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
myosin light chain 2
711937
Mouse
MGI:97272
17906
Rat
RGD:1564245
363925
Dog
myosin light chain 2
VGNC:43543
403614
Horse
myosin light chain 2
VGNC:20483
100147688
Species
Name
OMA
EggNOG
Inparanoid
Macaque
myosin light chain 2
Mouse
Rat
Dog
myosin light chain 2
Horse
myosin light chain 2
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10916-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (114)
Muscle contraction (R-HSA-397014)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 2 of 2
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Muscle contraction
Reactome
Striated Muscle Contraction
Name
Explore in Pharos
Explore in Source
Muscle contraction
Striated Muscle Contraction
Protein-Protein Interactions (186)
1 – 10 of 186
MYL5
Tbio
Novelty: 0.012802
p_int: 0.999999672
p_wrong: 3.28e-7
Score: 0.493
Data Source: BioPlex,STRINGDB
MYO5B
Tbio
Novelty: 0.01302142
p_int: 0.999658514
p_ni: 0.000340533
p_wrong: 9.53e-7
Score: 0.376
Data Source: BioPlex,STRINGDB
MYO19
Tbio
Novelty: 0.13070371
p_int: 0.994431867
p_ni: 0.005568133
Score: 0.357
Data Source: BioPlex,STRINGDB
ASPM
Tbio
Novelty: 0.00599688
p_int: 0.903038636
p_ni: 0.096961364
Score: 0.433
Data Source: BioPlex,STRINGDB
MYO5A
Tbio
Novelty: 0.00373224
p_int: 0.901407991
p_ni: 0.098589336
p_wrong: 0.000002673
Score: 0.3
Data Source: BioPlex,STRINGDB
IL36G
Tbio
Novelty: 0.04034902
p_int: 0.839357881
p_ni: 0.160449114
p_wrong: 0.000193005
Score: 0.314
Data Source: BioPlex,STRINGDB
MYH7
Tbio
Novelty: 0.00268092
Score: 0.996
Data Source: STRINGDB
MYLK
Tchem
Family: Kinase
Novelty: 0.00102277
Score: 0.992
Data Source: STRINGDB
MYH6
Tbio
Novelty: 0.00058671
Score: 0.991
Data Source: Reactome,STRINGDB
MYL3
Tbio
Novelty: 0.00493817
Score: 0.991
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  478.34

PubMed score by year
PubTator Score  170.7

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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