IRF1
Interferon regulatory factor 1
Protein Summary
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative ...more
- ENST00000245414
- ENSP00000245414
- ENSG00000125347
- ENST00000405885
- ENSP00000384406
- MAR
- IRF-1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
PubMedID | 1 | ||
virus perturbation | 1 | ||
biological process | 0.99 | ||
disease perturbation | 0.93 | ||
transcription factor binding site profile | 0.91 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1080.35 (req: < 5)
Gene RIFs: 209 (req: <= 3)
Antibodies: 441 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1080.35 (req: >= 5)
Gene RIFs: 209 (req: > 3)
Antibodies: 441 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 27
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (401)
Nearest Tclin Targets (3)
Upstream (1)
Downstream (2)
1 – 1 of 1
Pathways (24)
Reactome (7)
KEGG (5)
PathwayCommons (5)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Factors involved in megakaryocyte development and platelet production | ||||
Reactome | Hemostasis | ||||
Reactome | Immune System | ||||
Reactome | Interferon Signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Factors involved in megakaryocyte development and platelet production | ||||
Hemostasis | ||||
Immune System | ||||
Interferon Signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (4)
Components (5)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Mutant Phenotype (IMP) | NTNU_SB | |||
Inferred from Sequence Alignment (ISA) | NTNU_SB | |||
Traceable Author Statement (TAS) | UniProtKB | |||
Disease Associations (null)
GWAS Traits (63)
Items per page:
1 – 5 of 63
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
eosinophil count | 5 | 9 | 10 | 7.1 | 99.7 | ||||
eosinophil percentage of leukocytes | 2 | 5 | 7 | 98.6 | |||||
fibrinogen measurement | 6 | 6 | 6 | 6.8 | 98.5 | ||||
4 | 4 | 1 | 1.2 | 97.2 | |||||
8 | 9 | 1 | 1.1 | 96.1 | |||||
Items per page:
1 – 5 of 63
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
eosinophil count | 10 | 7.1 | 99.7 | ||||
eosinophil percentage of leukocytes | 7 | 98.6 | |||||
fibrinogen measurement | 6 | 6.8 | 98.5 | ||||
1 | 1.2 | 97.2 | |||||
1 | 1.1 | 96.1 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | interferon regulatory factor 1 | VGNC:4049 | 107974852 | |||||
Macaque | interferon regulatory factor 1 | 707788 | ||||||
Mouse | MGI:96590 | 16362 | ||||||
Rat | RGD:2920 | 24508 | ||||||
Dog | interferon regulatory factor 1 | VGNC:42091 | 100855872 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | interferon regulatory factor 1 | |||||
Macaque | interferon regulatory factor 1 | |||||
Mouse | ||||||
Rat | ||||||
Dog | interferon regulatory factor 1 | |||||
Publication Statistics
PubMed Score 1080.35
PubMed score by year
PubTator Score 695.25
PubTator score by year
Related Publications
Text Mined References (269)
GeneRif Annotations (209)
Items per page:
0 of 0
PMID | Year | Title |
|---|