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Tbio
IRF1
Interferon regulatory factor 1

Protein Summary
Description
Transcriptional regulator which displays a remarkable functional diversity in the regulation of cellular responses. These include the regulation of IFN and IFN-inducible genes, host response to viral and bacterial infections, regulation of many genes expressed during hematopoiesis, inflammation, immune responses and cell proliferation and differentiation, regulation of the cell cycle and induction of growth arrest and programmed cell death following DNA damage. Stimulates both innate and acquired immune responses through the activation of specific target genes and can act as a transcriptional activator and repressor regulating target genes by binding to an interferon-stimulated response element (ISRE) in their promoters. Its target genes for transcriptional activation activity include: genes involved in anti-viral response, such as IFN-alpha/beta, DDX58/RIG-I, TNFSF10/TRAIL, OAS1/2, PIAS1/GBP, EIF2AK2/PKR and RSAD2/viperin; antibacterial response, such as NOS2/INOS; anti-proliferative ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000245414
  • ENSP00000245414
  • ENSG00000125347
  • ENST00000405885
  • ENSP00000384406

Symbol
  • MAR
  • IRF-1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
1
virus perturbation
1
biological process
0.99
disease perturbation
0.93
transcription factor binding site profile
0.91


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1080.35   (req: < 5)
Gene RIFs: 209   (req: <= 3)
Antibodies: 441   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1080.35   (req: >= 5)
Gene RIFs: 209   (req: > 3)
Antibodies: 441   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 27
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (401)
IFNG
Tclin
Novelty:  0.00009731
Score:  0.98
Data Source:  STRINGDB
RELA
Tchem
Family:  TF
Novelty:  0.0007137
Score:  0.98
Data Source:  STRINGDB
ISG15
Tbio
Novelty:  0.00203781
Score:  0.98
Data Source:  STRINGDB
RSAD2
Tbio
Novelty:  0.0056473
Score:  0.978
Data Source:  STRINGDB
STAT2
Tbio
Family:  TF
Novelty:  0.00241454
Score:  0.975
Data Source:  STRINGDB
MX1
Tbio
Novelty:  0.00072554
Score:  0.974
Data Source:  STRINGDB
GBP1
Tbio
Novelty:  0.00634662
Score:  0.974
Data Source:  STRINGDB
IRF9
Tbio
Family:  TF
Novelty:  0.00751233
Score:  0.973
Data Source:  STRINGDB
STAT1
Tchem
Family:  TF
Novelty:  0.0003383
Score:  0.972
Data Source:  STRINGDB
IFIT1
Tbio
Novelty:  0.00562299
Score:  0.97
Data Source:  STRINGDB
Pathways (24)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Factors involved in megakaryocyte development and platelet production
Reactome
Hemostasis
Reactome
Immune System
Reactome
Interferon Signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Factors involved in megakaryocyte development and platelet production
Hemostasis
Immune System
Interferon Signaling
Viral Interactions (0)
No viral interactions found
Gene Ontology Terms (32)
Find Similar Targets
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Mutant Phenotype (IMP)
NTNU_SB
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
UniProtKB
Disease Associations (null)
No disease associations found
GWAS Traits (63)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
5
9
10
7.1
99.7
eosinophil percentage of leukocytes
2
5
7
98.6
fibrinogen measurement
6
6
6
6.8
98.5
4
4
1
1.2
97.2
8
9
1
1.1
96.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
eosinophil count
10
7.1
99.7
eosinophil percentage of leukocytes
7
98.6
fibrinogen measurement
6
6.8
98.5
1
1.2
97.2
1
1.1
96.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 1
VGNC:4049
107974852
Macaque
interferon regulatory factor 1
707788
Mouse
MGI:96590
16362
Rat
RGD:2920
24508
Dog
interferon regulatory factor 1
VGNC:42091
100855872
Species
Name
OMA
EggNOG
Inparanoid
Chimp
interferon regulatory factor 1
Macaque
interferon regulatory factor 1
Mouse
Rat
Dog
interferon regulatory factor 1
Publication Statistics
PubMed Score 1080.35
PubMed score by year
PubTator Score 695.25
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title