Pharos : Target Details

Tclin

Protein Summary

Description

Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more

Uniprot Accession IDs

Gene Name

Ensembl ID

ENST00000230882
ENSP00000230882
ENSG00000112964
ENST00000357703
ENSP00000350335
ENST00000537449
ENSP00000442206
ENST00000612382
ENSP00000478332
ENST00000612626
ENSP00000479846
ENST00000615111
ENSP00000478291
ENST00000618088
ENSP00000482373

Symbol

GHBP
GHIP

Illumination Graph

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
transcription factor perturbation	1

disease perturbation	0.96

biological process	0.95

PubMedID	0.92

hub protein	0.88

Protein Classes

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.26 (req: < 5)

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Gene RIFs: 197 (req: <= 3)

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Antibodies: 362 (req: <= 50)

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Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1019.26 (req: >= 5)

Gene RIFs: 197 (req: > 3)

Antibodies: 362 (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37

View GO Terms

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 4

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Protein Sequence and Structure

Residue Counts

Protein Sequence

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ProtVista Viewer

Expression Data (0 Tissues)

No expression data found

Related Tools

Target Illumination GWAS Analytics (TIGA)

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

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GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

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GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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Approved Drugs (4)

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1 – 4 of 4

Active Ligands (0)

No active ligands found

Protein-Protein Interactions (137)

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1 – 10 of 137

See Interactions on String-DB

GH1

Tbio

Novelty: 0.00072523

Score: 0.996