Protein Classes
Protein Summary
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more
- ENST00000230882
- ENSP00000230882
- ENSG00000112964
- ENST00000357703
- ENSP00000350335
- ENST00000537449
- ENSP00000442206
- ENST00000612382
- ENSP00000478332
- ENST00000612626
- ENSP00000479846
- ENST00000615111
- ENSP00000478291
- ENST00000618088
- ENSP00000482373
- GHBP
- GHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
biological process | 0.95 | ||
PubMedID | 0.92 | ||
hub protein | 0.88 | ||
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1012.34 (req: < 5)
Gene RIFs: 197 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1012.34 (req: >= 5)
Gene RIFs: 197 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Approved Drugs (3)
1 – 3 of 3
GWAS Traits (2)
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 3 | 4 | 95.5 | |||||
sex hormone-binding globulin measurement | 1 | 1 | 1 | 35.5 | |||||
Items per page:
1 – 2 of 2
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
heel bone mineral density | 4 | 95.5 | |||||
sex hormone-binding globulin measurement | 1 | 35.5 | |||||
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | growth hormone receptor | VGNC:4013 | 471560 | |||||
Macaque | growth hormone receptor | 697986 | ||||||
Mouse | MGI:95708 | 14600 | ||||||
Rat | RGD:2687 | 25235 | ||||||
Dog | growth hormone receptor | VGNC:41206 | 403721 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | growth hormone receptor | |||||
Macaque | growth hormone receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth hormone receptor | |||||
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (35)
Reactome (4)
KEGG (4)
PathwayCommons (5)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 4 of 4
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Growth hormone receptor signaling | ||||
Reactome | Immune System | ||||
Reactome | Prolactin receptor signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Growth hormone receptor signaling | ||||
Immune System | ||||
Prolactin receptor signaling | ||||
Gene Ontology Terms (48)
Functions (9)
Components (11)
Processes (28)
Items per page:
10
1 – 9 of 9
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Protein-Protein Interactions (137)
1 – 10 of 137
GH1
Novelty: 0.00072523
Score: 0.996
Data Source: Reactome,STRINGDB
JAK2
Family: Kinase
Novelty: 0.00022894
Score: 0.989
Data Source: Reactome,STRINGDB
STAT5B
Family: TF
Novelty: 0.00074178
Score: 0.983
Data Source: Reactome,STRINGDB
STAT5A
Family: TF
Novelty: 0.00074026
Score: 0.982
Data Source: Reactome,STRINGDB
GH2
Novelty: 0.00071871
Score: 0.975
Data Source: Reactome,STRINGDB
SOCS3
Novelty: 0.00106095
Score: 0.973
Data Source: Reactome,STRINGDB
SOCS2
Novelty: 0.0044049
Score: 0.97
Data Source: Reactome,STRINGDB
CISH
Novelty: 0.00145893
Score: 0.969
Data Source: Reactome,STRINGDB
PRL
Novelty: 0.0000905
Score: 0.962
Data Source: STRINGDB
IRS1
Novelty: 0.00048281
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score 1012.34
PubMed score by year
PubTator Score 1049.49
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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UniProt Keyword