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Tclin
GHR
Growth hormone receptor

Protein Summary
Description
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000230882
  • ENSP00000230882
  • ENSG00000112964
  • ENST00000357703
  • ENSP00000350335
  • ENST00000537449
  • ENSP00000442206
  • ENST00000612382
  • ENSP00000478332
  • ENST00000612626
  • ENSP00000479846
  • ENST00000615111
  • ENSP00000478291
  • ENST00000618088
  • ENSP00000482373

Symbol
  • GHBP
  • GHIP
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
disease perturbation
0.96
biological process
0.95
PubMedID
0.92
hub protein
0.88


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1012.34   (req: < 5)
Gene RIFs: 197   (req: <= 3)
Antibodies: 362   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1012.34   (req: >= 5)
Gene RIFs: 197   (req: > 3)
Antibodies: 362   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 37
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
2
3
4
95.5
sex hormone-binding globulin measurement
1
1
1
35.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
heel bone mineral density
4
95.5
sex hormone-binding globulin measurement
1
35.5
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
growth hormone receptor
VGNC:4013
471560
Macaque
growth hormone receptor
697986
Mouse
MGI:95708
14600
Rat
RGD:2687
25235
Dog
growth hormone receptor
VGNC:41206
403721
Species
Name
OMA
EggNOG
Inparanoid
Chimp
growth hormone receptor
Macaque
growth hormone receptor
Mouse
Rat
Dog
growth hormone receptor
Protein Data Bank (9)
1 – 5 of 9
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (35)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Growth hormone receptor signaling
Reactome
Immune System
Reactome
Prolactin receptor signaling
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Growth hormone receptor signaling
Immune System
Prolactin receptor signaling
Gene Ontology Terms (48)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Physical Interaction (IPI)
IntAct
Inferred from Physical Interaction (IPI)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Inferred from Sequence or structural Similarity (ISS)
BHF-UCL
Protein-Protein Interactions (137)
1 – 10 of 137
GH1
Tbio
Novelty: 0.00072523
Score: 0.996
Data Source: Reactome,STRINGDB
JAK2
Tclin
Family: Kinase
Novelty: 0.00022894
Score: 0.989
Data Source: Reactome,STRINGDB
STAT5B
Tchem
Family: TF
Novelty: 0.00074178
Score: 0.983
Data Source: Reactome,STRINGDB
STAT5A
Tchem
Family: TF
Novelty: 0.00074026
Score: 0.982
Data Source: Reactome,STRINGDB
GH2
Tbio
Novelty: 0.00071871
Score: 0.975
Data Source: Reactome,STRINGDB
SOCS3
Tbio
Novelty: 0.00106095
Score: 0.973
Data Source: Reactome,STRINGDB
SOCS2
Tbio
Novelty: 0.0044049
Score: 0.97
Data Source: Reactome,STRINGDB
CISH
Tbio
Novelty: 0.00145893
Score: 0.969
Data Source: Reactome,STRINGDB
PRL
Tbio
Novelty: 0.0000905
Score: 0.962
Data Source: STRINGDB
IRS1
Tbio
Novelty: 0.00048281
Score: 0.96
Data Source: STRINGDB
Publication Statistics
PubMed Score  1012.34

PubMed score by year
PubTator Score  1049.49

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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