Protein Summary
Receptor for pituitary gland growth hormone involved in regulating postnatal body growth. On ligand binding, couples to the JAK2/STAT5 pathway (By similarity). The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. This gene encodes a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain f ...more
- ENST00000230882
- ENSP00000230882
- ENSG00000112964
- ENST00000357703
- ENSP00000350335
- ENST00000537449
- ENSP00000442206
- ENST00000612382
- ENSP00000478332
- ENST00000612626
- ENSP00000479846
- ENST00000615111
- ENSP00000478291
- ENST00000618088
- ENSP00000482373
- GHBP
- GHIP
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
transcription factor perturbation | 1 | ||
disease perturbation | 0.96 | ||
biological process | 0.95 | ||
PubMedID | 0.92 | ||
hub protein | 0.88 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1019.26 (req: < 5)
Gene RIFs: 197 (req: <= 3)
Antibodies: 362 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1019.26 (req: >= 5)
Gene RIFs: 197 (req: > 3)
Antibodies: 362 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 37
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 4
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools

TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (4)
Active Ligands (0)
Protein-Protein Interactions (137)
Nearest Tclin Targets
Pathways (35)
Reactome (4)
KEGG (4)
PathwayCommons (5)
WikiPathways (22)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|---|
Reactome | Cytokine Signaling in Immune system | ||||
Reactome | Growth hormone receptor signaling | ||||
Reactome | Immune System | ||||
Reactome | Prolactin receptor signaling | ||||
Name | Explore in Pharos | Explore in Source | ||
---|---|---|---|---|
Cytokine Signaling in Immune system | ||||
Growth hormone receptor signaling | ||||
Immune System | ||||
Prolactin receptor signaling | ||||
Viral Interactions (0)
Gene Ontology Terms (48)
Functions (9)
Components (11)
Processes (28)
GO Term | Evidence | Assigned by | ||
---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|---|---|
heel bone mineral density | 2 | 4 | 5 | 93 | |||||
IGF-1 measurement | 1 | 2 | 2 | 71.9 | |||||
BMI-adjusted hip circumference | 1 | 2 | 2 | 71.1 | |||||
serum urea measurement | 1 | 1 | 1 | 33.1 | |||||
body height | 1 | 1 | 1 | 29.9 | |||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
---|---|---|---|---|---|---|---|
heel bone mineral density | 5 | 93 | |||||
IGF-1 measurement | 2 | 71.9 | |||||
BMI-adjusted hip circumference | 2 | 71.1 | |||||
serum urea measurement | 1 | 33.1 | |||||
body height | 1 | 29.9 | |||||
Find similar targets by:
IDG Resources
Orthologs (13)
1 – 5 of 13
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|---|---|
Chimp | growth hormone receptor | VGNC:4013 | 471560 | |||||
Macaque | growth hormone receptor | 697986 | ||||||
Mouse | MGI:95708 | 14600 | ||||||
Rat | RGD:2687 | 25235 | ||||||
Dog | growth hormone receptor | VGNC:41206 | 403721 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
---|---|---|---|---|---|---|
Chimp | growth hormone receptor | |||||
Macaque | growth hormone receptor | |||||
Mouse | ||||||
Rat | ||||||
Dog | growth hormone receptor | |||||
Publication Statistics
PubMed Score 1019.26
PubMed score by year
PubTator Score 1049.49
PubTator score by year
Related Publications
Text Mined References (302)
GeneRif Annotations (197)
Items per page:
0 of 0
PMID | Year | Title |
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