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Tbio
CLU
Clusterin

Protein Summary
Description
Isoform 1 functions as extracellular chaperone that prevents aggregation of nonnative proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysosomal or proteasomal degradation. Secreted isoform 1 protects cells against apoptosis and against cytolysis by complement. Intracellular isoforms interact with ubiquitin and SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complexes and promote the ubiquitination and subsequent proteasomal degradation of target proteins. Promotes proteasomal degradation of COMMD1 and IKBKB. Modulates NF-kappa-B transcriptional ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000316403
  • ENSP00000315130
  • ENSG00000120885
  • ENST00000405140
  • ENSP00000385419
  • ENST00000523500
  • ENSP00000429620

Symbol
  • APOJ
  • CLI
  • KUB1
  • CLI
  • AAG4
  • APOJ
  • CLU1
  • CLU2
  • KUB1
  • SGP2
  • APO-J
  • SGP-2
  • SP-40
  • TRPM2
  • TRPM-2
  • NA1/NA2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
transcription factor perturbation
1
virus perturbation
0.96
PubMedID
0.95
chemical
0.87


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
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GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1985.62   (req: < 5)
Gene RIFs: 385   (req: <= 3)
Antibodies: 1092   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1985.62   (req: >= 5)
Gene RIFs: 385   (req: > 3)
Antibodies: 1092   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 57
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
7
4
0
1.2
98.6
family history of Alzheimer’s disease
1
2
0
8.7
82.7
late-onset Alzheimers disease
1
1
0
1.1
56.4
refractive error measurement
1
1
0
5.7
18.5
age at onset
1
1
0
5.7
18.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
0
1.2
98.6
family history of Alzheimer’s disease
0
8.7
82.7
late-onset Alzheimers disease
0
1.1
56.4
refractive error measurement
0
5.7
18.5
age at onset
0
5.7
18.5
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
clusterin
VGNC:908
464075
Macaque
clusterin
677866
Mouse
MGI:88423
12759
Rat
RGD:3907
24854
Dog
clusterin
VGNC:39369
442971
Species
Name
OMA
EggNOG
Inparanoid
Chimp
clusterin
Macaque
clusterin
Mouse
Rat
Dog
clusterin
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10909-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (20)
Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 10
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Antimicrobial peptides
Reactome
Complement cascade
Reactome
Hemostasis
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Antimicrobial peptides
Complement cascade
Hemostasis
Immune System
Innate Immune System
Gene Ontology Terms (79)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
ARUK-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Physical Interaction (IPI)
ARUK-UCL
Inferred from Sequence or structural Similarity (ISS)
ParkinsonsUK-UCL
Traceable Author Statement (TAS)
ARUK-UCL
Protein-Protein Interactions (321)
1 – 10 of 321
SDK2
Tdark
Novelty: 0.08867136
p_int: 0.999979449
p_ni: 0.000020551
Score: 0.202
Data Source: BioPlex,STRINGDB
ATP2B2
Tbio
Family: Transporter
Novelty: 0.007782
p_int: 0.999913591
p_ni: 0.000086409
Score: 0.204
Data Source: BioPlex,STRINGDB
PTPRS
Tchem
Family: Enzyme
Novelty: 0.00587115
p_int: 0.999888761
p_ni: 0.000111239
Score: 0.17
Data Source: BioPlex,STRINGDB
TENM3
Tbio
Novelty: 0.0251948
p_int: 0.999738844
p_ni: 0.000261155
p_wrong: 1e-9
Score: 0.359
Data Source: BioPlex,STRINGDB
FAT4
Tbio
Novelty: 0.01739918
p_int: 0.999655832
p_ni: 0.000344168
Data Source: BioPlex
FBXO27
Tdark
Novelty: 0.27910336
p_int: 0.999641451
p_ni: 0.000008264
p_wrong: 0.000350285
Score: 0.187
Data Source: BioPlex,STRINGDB
CBWD3
Tdark
Novelty: 0.03639787
p_int: 0.99948875
p_ni: 0.000511242
p_wrong: 9e-9
Data Source: BioPlex
KIAA0355
Tdark
Novelty: 0.97113831
p_int: 0.999447195
p_ni: 0.000552805
Score: 0.185
Data Source: BioPlex,STRINGDB
DHX57
Tdark
Family: Enzyme
Novelty: 0.8244078
p_int: 0.998109936
p_ni: 0.001890064
Data Source: BioPlex
ITGA8
Tbio
Novelty: 0.0220023
p_int: 0.997451574
p_ni: 0.00254841
p_wrong: 1.6e-8
Data Source: BioPlex
Publication Statistics
PubMed Score  1985.62

PubMed score by year
PubTator Score  901.05

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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