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Tclin
THRB
Thyroid hormone receptor beta

Protein Summary
Description
Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280696
  • ENSP00000280696
  • ENSG00000151090
  • ENST00000356447
  • ENSP00000348827
  • ENST00000396671
  • ENSP00000379904
  • ENST00000415021
  • ENSP00000404898
  • ENST00000416420
  • ENSP00000414444
  • ENST00000642307
  • ENSP00000494618
  • ENST00000643772
  • ENSP00000496029
  • ENST00000644321
  • ENSP00000496616
  • ENST00000645139
  • ENSP00000493709
  • ENST00000646209
  • ENSP00000496686
  • ENST00000646432
  • ENSP00000496509

Symbol
  • ERBA2
  • NR1A2
  • THR1
  • GRTH
  • PRTH
  • THR1
  • ERBA2
  • NR1A2
  • THRB1
  • THRB2
  • C-ERBA-2
  • C-ERBA-BETA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.97
hub protein
0.85
protein domain
0.85
biological process
0.84
transcription factor binding site profile
0.82


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.66   (req: < 5)
Gene RIFs: 146   (req: <= 3)
Antibodies: 474   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 559.66   (req: >= 5)
Gene RIFs: 146   (req: > 3)
Antibodies: 474   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 201
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
GWAS Traits (27)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
97.8
mean corpuscular hemoglobin concentration
3
3
3
94.7
red blood cell density measurement
2
2
2
92.8
mean corpuscular volume
5
3
5
92.7
intelligence
1
1
0
7.4
88
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
97.8
mean corpuscular hemoglobin concentration
3
94.7
red blood cell density measurement
2
92.8
mean corpuscular volume
5
92.7
intelligence
0
7.4
88
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor beta
VGNC:8014
470771
Macaque
thyroid hormone receptor beta
100429549
Mouse
MGI:98743
21834
Rat
RGD:3858
24831
Dog
thyroid hormone receptor beta
VGNC:47355
403599
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thyroid hormone receptor beta
Macaque
thyroid hormone receptor beta
Mouse
Rat
Dog
thyroid hormone receptor beta
Protein Structure (19 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10828-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 19
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (17)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Metabolism of proteins
Reactome
Nuclear Receptor transcription pathway
Reactome
Post-translational protein modification
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Metabolism of proteins
Nuclear Receptor transcription pathway
Post-translational protein modification
Gene Ontology Terms (38)
Items per page:
10
1 – 10 of 15
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Sequence Alignment (ISA)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Protein-Protein Interactions (116)
1 – 10 of 116
ACTA2
Tbio
Novelty: 0.00199354
p_int: 0.999448748
p_ni: 0.000551252
Data Source: BioPlex
ACTBL2
Tbio
Novelty: 0.18080702
p_int: 0.996724432
p_ni: 0.003275568
Data Source: BioPlex
ACTB
Tbio
Novelty: 0.00006048
p_int: 0.99534866
p_ni: 0.00465134
Score: 0.26
Data Source: BioPlex,STRINGDB
PDLIM7
Tbio
Novelty: 0.00544518
p_int: 0.947246794
p_ni: 0.052753206
Score: 0.238
Data Source: BioPlex,STRINGDB
DNM3
Tbio
Novelty: 0.02365643
p_int: 0.808721726
p_ni: 0.191243084
p_wrong: 0.00003519
Score: 0.238
Data Source: BioPlex,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
p_int: 0.804799077
p_ni: 0.170661903
p_wrong: 0.02453902
Score: 0.225
Data Source: BioPlex,STRINGDB
RXRA
Tclin
Family: NR
Novelty: 0.00244343
Score: 0.995
Data Source: STRINGDB
NCOR2
Tchem
Family: TF
Novelty: 0.00066449
Score: 0.971
Data Source: STRINGDB
NCOA1
Tchem
Family: Epigenetic
Novelty: 0.00344663
Score: 0.97
Data Source: STRINGDB
RXRG
Tclin
Family: NR
Novelty: 0.01646377
Score: 0.97
Data Source: STRINGDB
Publication Statistics
PubMed Score  559.66

PubMed score by year
PubTator Score  284.27

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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