Tclin THRA Thyroid hormone receptor alpha

Protein Summary

Description

Isoform Alpha-1: Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine. Isoform Alpha-2: Does not bind thyroid hormone and functions as a weak dominant negative inhibitor of thyroid hormone action. The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P10827
• A8K3B5
• P21205
• Q8N6A1
• Q96H73

Gene Name

• THRA

Ensembl ID

• ENST00000264637
• ENSP00000264637
• ENSG00000126351
• ENST00000394121
• ENSP00000377679
• ENST00000450525
• ENSP00000395641
• ENST00000546243
• ENSP00000443972
• ENST00000584985
• ENSP00000463466

Symbol

• EAR7
• ERBA1
• NR1A1
• THRA1
• THRA2
• AR7
• EAR7
• ERBA
• CHNG6
• ERBA1
• NR1A1
• THRA1
• THRA2
• ERB-T-1
• c-ERBA-1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological process	0.99
molecular function	0.99
hub protein	0.94
protein domain	0.85
transcription factor	0.83

Protein Classes

PANTHER Classes

Protein / Transcription Factor / Thyroid Hormone Receptor Alpha

Protein / Receptor / Thyroid Hormone Receptor Alpha

Protein / Nucleic Acid Binding / Thyroid Hormone Receptor Alpha

Protein / ... / C4 Zinc Finger Nuclear Receptor / Thyroid Hormone Receptor Alpha

DTO Classes

Protein / Nuclear Receptor / Thyroid Hormone Receptors / Thyroid Hormone Receptor Alpha

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.78   (req: < 5)

Gene RIFs: 87   (req: <= 3)

Antibodies: 578   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 602.78   (req: >= 5)

Gene RIFs: 87   (req: > 3)

Antibodies: 578   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 44

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 104

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3