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Tbio
CD28
T-cell-specific surface glycoprotein CD28

Protein Summary
Description
Involved in T-cell activation, the induction of cell proliferation and cytokine production and promotion of T-cell survival. Enhances the production of IL4 and IL10 in T-cells in conjunction with TCR/CD3 ligation and CD40L costimulation (PubMed:8617933). Isoform 3 enhances CD40L-mediated activation of NF-kappa-B and kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). The protein encoded by this gene is essential for T-cell proliferation and survival, cytokine production, and T-helper type-2 development. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jul 2011]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000324106
  • ENSP00000324890
  • ENSG00000178562
  • ENST00000374481
  • ENSP00000363605
  • ENST00000458610
  • ENSP00000393648

Symbol
  • Tp44
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
phenotype
0.79
biological term
0.78
gene perturbation
0.74
tissue sample
0.7


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2355.03   (req: < 5)
Gene RIFs: 229   (req: <= 3)
Antibodies: 2086   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2355.03   (req: >= 5)
Gene RIFs: 229   (req: > 3)
Antibodies: 2086   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 33
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (12)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
3
4
2
1.2
81.2
eosinophil count
3
2
4
77.1
eosinophil percentage of leukocytes
1
1
1
74.6
4
3
2
1.1
72.9
lymphocyte count
3
3
3
69.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
2
1.2
81.2
eosinophil count
4
77.1
eosinophil percentage of leukocytes
1
74.6
2
1.1
72.9
lymphocyte count
3
69.3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
CD28 molecule
VGNC:127
470617
Macaque
CD28 molecule
705313
Mouse
MGI:88327
12487
Rat
RGD:2299
25660
Dog
CD28 molecule
VGNC:38944
403646
Species
Name
OMA
EggNOG
Inparanoid
Chimp
CD28 molecule
Macaque
CD28 molecule
Mouse
Rat
Dog
CD28 molecule
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10747-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (74)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 21
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
CD28 co-stimulation
Reactome
CD28 dependent PI3K/Akt signaling
Reactome
CD28 dependent Vav1 pathway
Reactome
Constitutive Signaling by Aberrant PI3K in Cancer
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
CD28 co-stimulation
CD28 dependent PI3K/Akt signaling
CD28 dependent Vav1 pathway
Constitutive Signaling by Aberrant PI3K in Cancer
Gene Ontology Terms (40)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
BHF-UCL
Traceable Author Statement (TAS)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Non-traceable Author Statement (NAS)
UniProtKB
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (410)
1 – 10 of 410
OR56B4
Tdark
Family:  oGPCR
Novelty:  1.79104478
p_int:  0.999999454
p_ni:  2.8e-7
p_wrong:  2.66e-7
Data Source:  BioPlex
EFNB2
Tbio
Novelty:  0.00255095
p_int:  0.986829808
p_ni:  0.007865896
p_wrong:  0.005304296
Data Source:  BioPlex
YWHAZ
Tchem
Novelty:  0.00210582
p_int:  0.942690823
p_ni:  0.057309177
Data Source:  BioPlex
YWHAE
Tbio
Novelty:  0.00431876
p_int:  0.909275375
p_ni:  0.090724625
Data Source:  BioPlex
YWHAH
Tchem
Novelty:  0.01000071
p_int:  0.899638011
p_ni:  0.100361989
Data Source:  BioPlex
PLXDC2
Tbio
Novelty:  0.06496695
p_int:  0.897263025
p_ni:  0.102736975
Data Source:  BioPlex
TMEM192
Tbio
Novelty:  0.30699087
p_int:  0.872446069
p_ni:  0.127546671
p_wrong:  0.00000726
Data Source:  BioPlex
LGALS1
Tchem
Novelty:  0.00106509
p_int:  0.871149
p_ni:  0.128838513
p_wrong:  0.000012486
Data Source:  BioPlex
YWHAB
Tchem
Novelty:  0.00614093
p_int:  0.852764651
p_ni:  0.147235349
Data Source:  BioPlex
CD80
Tclin
Novelty:  0.00031181
Score:  0.997
Data Source:  Reactome,STRINGDB
Publication Statistics
PubMed Score  2355.03

PubMed score by year
PubTator Score  2063.04

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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