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Tbio
UROS
Uroporphyrinogen-III synthase

Protein Summary
Description
Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme). The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000368786
  • ENSP00000357775
  • ENSG00000188690
  • ENST00000368797
  • ENSP00000357787
  • ENST00000649619
  • ENSP00000497359

Symbol
  • UROIIIS
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
virus perturbation
0.97
histone modification site profile
0.9
disease perturbation
0.79
gene perturbation
0.7
transcription factor binding site profile
0.68


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.53   (req: < 5)
Gene RIFs: 9   (req: <= 3)
Antibodies: 83   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 125.53   (req: >= 5)
Gene RIFs: 9   (req: > 3)
Antibodies: 83   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 4
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Expression Data (0 Tissues)
No expression data found
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (65)
MOCS1
Tclin
Novelty:  0.02785369
p_int:  0.99898598
p_ni:  0.001013985
p_wrong:  3.5e-8
Score:  0.394
Data Source:  BioPlex,STRINGDB
BOLA1
Tbio
Novelty:  0.1092583
p_int:  0.987976117
p_ni:  0.012003665
p_wrong:  0.000020217
Score:  0.226
Data Source:  BioPlex,STRINGDB
GCLM
Tbio
Family:  Enzyme
Novelty:  0.00395815
p_int:  0.975193122
p_ni:  0.001605464
p_wrong:  0.023201414
Score:  0.34
Data Source:  BioPlex,STRINGDB
TCEAL1
Tbio
Novelty:  0.02210924
p_int:  0.884477609
p_ni:  0.115522391
Score:  0.161
Data Source:  BioPlex,STRINGDB
HMBS
Tbio
Family:  Enzyme
Novelty:  0.00193847
Score:  0.996
Data Source:  STRINGDB
UROD
Tbio
Family:  Enzyme
Novelty:  0.00337791
Score:  0.994
Data Source:  STRINGDB
ALAD
Tbio
Family:  Enzyme
Novelty:  0.00092757
Score:  0.978
Data Source:  STRINGDB
CPOX
Tbio
Family:  Enzyme
Novelty:  0.01097519
Score:  0.962
Data Source:  STRINGDB
FECH
Tchem
Family:  Enzyme
Novelty:  0.00282289
Score:  0.941
Data Source:  STRINGDB
PPOX
Tchem
Family:  Enzyme
Novelty:  0.00652809
Score:  0.924
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (10)
Heme biosynthesis (R-HSA-189451)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Heme biosynthesis
Reactome
Metabolism
Reactome
Metabolism of porphyrins
Name
Explore in Pharos
Explore in Source
Heme biosynthesis
Metabolism
Metabolism of porphyrins
Viral Interactions (0)
No viral interactions found
Disease Associations (null)
No disease associations found
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
1
1
74.2
mean corpuscular hemoglobin concentration
1
1
1
60.5
appendicular lean mass
1
1
1
0.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
74.2
mean corpuscular hemoglobin concentration
1
60.5
appendicular lean mass
1
0.3
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
uroporphyrinogen III synthase
VGNC:9782
450813
Macaque
uroporphyrinogen III synthase
696043
Mouse
MGI:98917
22276
Rat
RGD:1310396
309070
Dog
uroporphyrinogen III synthase
VGNC:48170
492116
Species
Name
OMA
EggNOG
Inparanoid
Chimp
uroporphyrinogen III synthase
Macaque
uroporphyrinogen III synthase
Mouse
Rat
Dog
uroporphyrinogen III synthase
Publication Statistics
PubMed Score 125.53
PubMed score by year
PubTator Score 119.47
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title