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Tbio
RBP3
Retinol-binding protein 3

Protein Summary
Description
IRBP shuttles 11-cis and all trans retinoids between the retinol isomerase in the pigment epithelium and the visual pigments in the photoreceptor cells of the retina. Interphotoreceptor retinol-binding protein is a large glycoprotein known to bind retinoids and found primarily in the interphotoreceptor matrix of the retina between the retinal pigment epithelium and the photoreceptor cells. It is thought to transport retinoids between the retinal pigment epithelium and the photoreceptors, a critical role in the visual process.The human IRBP gene is approximately 9.5 kbp in length and consists of four exons separated by three introns. The introns are 1.6-1.9 kbp long. The gene is transcribed by photoreceptor and retinoblastoma cells into an approximately 4.3-kilobase mRNA that is translated and processed into a glycosylated protein of 135,000 Da. The amino acid sequence of human IRBP can be divided into four contiguous homology domains with 33-38% identity, suggesting a series of gene du ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000584701
  • ENSP00000463151
  • ENSG00000265203

Symbol
  • IRBP
  • RBPI
  • RP66
  • D10S64
  • D10S65
  • D10S66
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
cell type or tissue
0.61
cell line
0.59
molecular function
0.56
tissue
0.54
disease
0.43


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 534.49   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 209   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 534.49   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 209   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 7
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (1)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
1
2
79.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
corneal topography
2
79.1
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 3
VGNC:5716
450440
Macaque
retinol binding protein 3
711582
Mouse
MGI:97878
19661
Rat
RGD:3545
24711
Dog
retinol binding protein 3
VGNC:45431
489084
Species
Name
OMA
EggNOG
Inparanoid
Chimp
retinol binding protein 3
Macaque
retinol binding protein 3
Mouse
Rat
Dog
retinol binding protein 3
Protein Structure (0 Structures, 1 AlphaFold Model)
RepresentationColor Scheme
AF-P10745-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

Pathways (7)
G alpha (i) signalling events (R-HSA-418594)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 7
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Signal Transduction
Reactome
Signaling by GPCR
Reactome
The canonical retinoid cycle in rods (twilight vision)
Name
Explore in Pharos
Explore in Source
G alpha (i) signalling events
GPCR downstream signalling
Signal Transduction
Signaling by GPCR
The canonical retinoid cycle in rods (twilight vision)
Gene Ontology Terms (11)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Traceable Author Statement (TAS)
Reactome
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (59)
1 – 10 of 59
RCVRN
Tbio
Novelty: 0.00266222
Score: 0.943
Data Source: STRINGDB
SAG
Tbio
Novelty: 0.00040944
Score: 0.804
Data Source: STRINGDB
OPN1SW
Tbio
Family: GPCR
Novelty: 0.00688397
Score: 0.781
Data Source: STRINGDB
HR
Tbio
Family: Enzyme
Novelty: 0.01594409
Score: 0.756
Data Source: STRINGDB
LRBA
Tbio
Novelty: 0.00093369
Score: 0.748
Data Source: STRINGDB
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.736
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.731
Data Source: STRINGDB
GNAT2
Tbio
Novelty: 0.01683655
Score: 0.73
Data Source: STRINGDB
RLBP1
Tbio
Novelty: 0.00526176
Score: 0.729
Data Source: STRINGDB
AIRE
Tbio
Family: TF; Epigenetic
Novelty: 0.00158659
Score: 0.716
Data Source: STRINGDB
Publication Statistics
PubMed Score  534.49

PubMed score by year
PubTator Score  212.02

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer