Tchem ALPG Alkaline phosphatase, germ cell type

Protein Summary

Description

There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The product of this gene is a membrane bound glycosylated enzyme, localized to testis, thymus and certain germ cell tumors, that is closely related to both the placental and intestinal forms of alkaline phosphatase. [provided by RefSeq, Jul 2008]

Uniprot Accession IDs

• P10696
• A8KAF2
• Q16727
• Q53S81
• Q96CM1

Gene Name

• ALPG

Ensembl ID

• ENST00000295453
• ENSP00000295453
• ENSG00000163286

Symbol

• ALPPL
• ALPPL2
• GCAP
• ALPPL
• ALPPL2

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
cell line	0.62
protein domain	0.58
disease	0.55
gene perturbation	0.53
cellular component	0.51

Protein Classes

PANTHER Classes

Protein / Hydrolase / Phosphatase / Alkaline Phosphatase, Germ Cell Type

DTO Classes

Protein / Enzyme / Hydrolase / Phosphatase / Alkaline Phosphatase, Placental-like

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.02   (req: < 5)

Gene RIFs: 8   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 175.02   (req: >= 5)

Gene RIFs: 8   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 2

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 7

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0