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Tchem
TFPI
Tissue factor pathway inhibitor

Protein Summary
Description
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233156
  • ENSP00000233156
  • ENSG00000003436
  • ENST00000339091
  • ENSP00000342306
  • ENST00000392365
  • ENSP00000376172
  • ENST00000409676
  • ENSP00000386344

Symbol
  • LACI
  • TFPI1
  • EPI
  • TFI
  • LACI
  • TFPI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.98
PubMedID
0.98
small molecule perturbation
0.87
interacting protein
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.77   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 628   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1987.77   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 628   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 501
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0