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Tchem
TFPI
Tissue factor pathway inhibitor

Protein Summary
Description
Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. This gene encodes a Kunitz-type serine protease inhibitor that regulates the tissue factor (TF)-dependent pathway of blood coagulation. The coagulation process initiates with the formation of a factor VIIa-TF complex, which proteolytically activates additional proteases (factors IX and X) and ultimately leads to the formation of a fibrin clot. The product of this gene inhibits the activated factor X and VIIa-TF proteases in an autoregulatory loop. Inhibition of the encoded protein restores hemostasis in animal models of hemophilia. This gene encodes multiple protein isoforms that differ in their inhibitory activity, specificity and cellular localization. [provided by RefSeq, Jul 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000233156
  • ENSP00000233156
  • ENSG00000003436
  • ENST00000339091
  • ENSP00000342306
  • ENST00000392365
  • ENSP00000376172
  • ENST00000409676
  • ENSP00000386344

Symbol
  • LACI
  • TFPI1
  • EPI
  • TFI
  • LACI
  • TFPI1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
transcription factor perturbation
1
gene perturbation
0.98
PubMedID
0.98
small molecule perturbation
0.87
interacting protein
0.76


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1836.18   (req: < 5)
Gene RIFs: 176   (req: <= 3)
Antibodies: 628   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1836.18   (req: >= 5)
Gene RIFs: 176   (req: > 3)
Antibodies: 628   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1125
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Protein-Protein Interactions (97)
KCNIP4
Tbio
Family:  IC
Novelty:  0.00973829
p_int:  0.801663715
p_ni:  0.19833593
p_wrong:  3.55e-7
Score:  0.375
Data Source:  BioPlex,STRINGDB
F3
Tchem
Novelty:  0.00006457
Score:  0.991
Data Source:  Reactome,STRINGDB
F10
Tclin
Family:  Enzyme
Novelty:  0.00063008
Score:  0.987
Data Source:  Reactome,STRINGDB
F7
Tchem
Family:  Enzyme
Novelty:  0.0002521
Score:  0.979
Data Source:  Reactome,STRINGDB
SDC4
Tbio
Novelty:  0.00319073
Score:  0.911
Data Source:  STRINGDB
SERPINC1
Tclin
Novelty:  0.00008721
Score:  0.864
Data Source:  STRINGDB
THBD
Tbio
Novelty:  0.00039359
Score:  0.852
Data Source:  STRINGDB
SRSF11
Tbio
Novelty:  0.17035604
Score:  0.818
Data Source:  STRINGDB
F2
Tclin
Family:  Enzyme
Novelty:  0.00004833
Score:  0.811
Data Source:  STRINGDB
SRSF7
Tbio
Novelty:  0.03712415
Score:  0.793
Data Source:  STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (8)
Extrinsic Pathway of Fibrin Clot Formation (R-HSA-140834)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 3 of 3
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Extrinsic Pathway of Fibrin Clot Formation
Reactome
Formation of Fibrin Clot (Clotting Cascade)
Reactome
Hemostasis
Name
Explore in Pharos
Explore in Source
Extrinsic Pathway of Fibrin Clot Formation
Formation of Fibrin Clot (Clotting Cascade)
Hemostasis
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (14)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
5
3
6
77.8
myeloid white cell count
1
1
1
68.8
waist-hip ratio
1
2
2
63
BMI-adjusted waist circumference
1
2
2
61.8
waist circumference
1
2
2
57.1
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
BMI-adjusted waist-hip ratio
6
77.8
myeloid white cell count
1
68.8
waist-hip ratio
2
63
BMI-adjusted waist circumference
2
61.8
waist circumference
2
57.1
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (11)
1 – 5 of 11
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
tissue factor pathway inhibitor
VGNC:2879
470603
Macaque
tissue factor pathway inhibitor
613026
Mouse
MGI:1095418
21788
Rat
RGD:61914
29436
Dog
tissue factor pathway inhibitor
VGNC:47301
403921
Species
Name
OMA
EggNOG
Inparanoid
Chimp
tissue factor pathway inhibitor
Macaque
tissue factor pathway inhibitor
Mouse
Rat
Dog
tissue factor pathway inhibitor
Publication Statistics
PubMed Score 1836.18
PubMed score by year
PubTator Score 1010.43
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title