Tbio CHGA Chromogranin-A

Protein Summary

Description

Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. The protein encoded by this gene is a member of the chromogranin/secretogranin family of neuroendocrine secretory proteins. It is found in secretory vesicles of neurons and endocrine cells. This gene product is a precursor to three biologically active peptides; vasostatin, pancreastatin, and parastatin. These peptides act as autocrine or paracrine negative modulators of the neuroendocrine system. Two other peptides, catestatin and chromofungin, have antimicrobial activity and antifungal activity, respectively. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2014]

Uniprot Accession IDs

• P10645
• B2R9E9
• Q53FA8
• Q6NR84
• Q96E84
• Q96GL7
• Q9BQB5
• CgA

Gene Name

• CHGA

Ensembl ID

• ENST00000216492
• ENSP00000216492
• ENSG00000100604
• ENST00000613166
• ENSP00000478198
• ENSG00000276781

Symbol

• CGA

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
gene perturbation	0.91
disease	0.7
biological process	0.67
biological term	0.67
PubMedID	0.61

Related Tools

GENEVA

GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.

Go To Tool

GlyGen

GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.

Go To Tool

ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

Go To Tool

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2837.66   (req: < 5)

Gene RIFs: 203   (req: <= 3)

Antibodies: 2646   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2837.66   (req: >= 5)

Gene RIFs: 203   (req: > 3)

Antibodies: 2646   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 23

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Orthologs (12)

1 – 5 of 12

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	chromogranin A	VGNC:13024	453120
Macaque	chromogranin A		574388
Mouse	chromogranin A	MGI:88394	12652
Rat	chromogranin A	RGD:2338	24258
Horse	chromogranin A	VGNC:49357	100033828

Species	Name	OMA	EggNOG	Inparanoid
Chimp	chromogranin A
Macaque	chromogranin A
Mouse	chromogranin A
Rat	chromogranin A
Horse	chromogranin A

Protein Structure (1 Structure, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10645-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (3)

Reactome (3)

Antimicrobial peptides (R-HSA-6803157)

Click on a row in the table to change the structure displayed.

Find Similar Targets

Items per page:

5

1 – 3 of 3

Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Antimicrobial peptides	89 targets	R-HSA-6803157
Reactome	Immune System	2246 targets	R-HSA-168256
Reactome	Innate Immune System	1188 targets	R-HSA-168249

Name	Explore in Pharos	Explore in Source
Antimicrobial peptides	89 targets	R-HSA-6803157
Immune System	2246 targets	R-HSA-168256
Innate Immune System	1188 targets	R-HSA-168249

Gene Ontology Terms (30)

Components (7)

Processes (23)

Find Similar Targets

Items per page:

10

1 – 7 of 7

GO Term	Evidence	Assigned by
perinuclear region of cytoplasm	Inferred from Direct Assay (IDA)	UniProtKB
chromaffin granule	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
extracellular space	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
secretory granule	Inferred from Sequence or structural Similarity (ISS)	BHF-UCL
extracellular region	Traceable Author Statement (TAS)	Reactome
mast cell granule	Inferred from Electronic Annotation (IEA)	GOC
transport vesicle membrane	Inferred from Electronic Annotation (IEA)	UniProtKB-SubCell

Protein-Protein Interactions (180)

Explore Interacting Targets

1 – 10 of 180

• See Interactions on String-DB

SAPCD2

Tbio

Novelty: 0.06798955

p_int: 0.999766392

p_ni: 0.00023359

p_wrong: 1.8e-8

Score: 0.269

Data Source: BioPlex,STRINGDB

SGF29

Tbio

Family: Epigenetic

Novelty: 0.0426456

p_int: 0.883486649

p_ni: 0.116513301

p_wrong: 4.9e-8

Score: 0.179

Data Source: BioPlex,STRINGDB

DENR

Tbio

Novelty: 0.00653432

p_int: 0.76724615

p_ni: 0.232733832

p_wrong: 0.000020019

Score: 0.189

Data Source: BioPlex,STRINGDB

SCG3

Tbio

Novelty: 0.02153066

Score: 0.979

Data Source: STRINGDB

SYP

Tbio

Novelty: 0.00021543

Score: 0.945

Data Source: STRINGDB

CHGB

Tbio

Novelty: 0.00484507

Score: 0.943

Data Source: STRINGDB

ENO2

Tbio

Family: Enzyme

Novelty: 0.00016748

Score: 0.925

Data Source: STRINGDB

SST

Tbio

Novelty: 0.00005944

Score: 0.892

Data Source: STRINGDB

SYT1

Tbio

Novelty: 0.00176103

Score: 0.866

Data Source: STRINGDB

SCG2

Tbio

Novelty: 0.00389492

Score: 0.86

Data Source: STRINGDB

Publication Statistics

PubMed Score  2837.66

PubMed score by year

Reset Zoom

PubTator Score  3416.64

PubTator score by year

Reset Zoom

Amino Acid Sequence

Residue Counts

Protein Sequence

Show Full Sequence

ProtVista Viewer

Find similar targets by:

UniProt Keyword Find Similar Targets

3D-structure
Amidation
Antibiotic
Antimicrobial
Calcium
Cleavage on pair of basic residues
Complete proteome
Cytoplasmic vesicle
Direct protein sequencing
Disulfide bond

MGI Phenotype Find Similar Targets

cardiovascular system phenotype
endocrine/exocrine gland phenotype
growth/size/body region phenotype
homeostasis/metabolism phenotype
mortality/aging
muscle phenotype
nervous system phenotype
renal/urinary system phenotype