Protein Summary
Pancreastatin: Strongly inhibits glucose induced insulin release from the pancreas. Catestatin: Inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist (PubMed:15326220). Displays antibacterial activity against Gram-positive bacteria S.aureus and M.luteus, and Gram-negative bacteria E.coli and P.aeruginosa (PubMed:15723172 and PubMed:24723458). Can induce mast cell migration, degranulation and production of cytokines and chemokines (PubMed:21214543). Acts as a potent scavenger of free radicals in vitro (PubMed:24723458). May play a role in the regulation of cardiac function and blood pressure (PubMed:18541522). Serpinin: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. The protein encoded by ...more
- ENST00000216492
- ENSP00000216492
- ENSG00000100604
- ENST00000613166
- ENSP00000478198
- ENSG00000276781
- CGA
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
gene perturbation | 0.91 | ||
disease | 0.7 | ||
biological process | 0.67 | ||
biological term | 0.67 | ||
PubMedID | 0.61 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2885.89 (req: < 5)
Gene RIFs: 203 (req: <= 3)
Antibodies: 2646 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 2885.89 (req: >= 5)
Gene RIFs: 203 (req: > 3)
Antibodies: 2646 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 23
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligand: 0
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (0)
Protein-Protein Interactions (180)
SAPCD2
Novelty: 0.06798955
p_int: 0.999766392
p_ni: 0.00023359
p_wrong: 1.8e-8
Score: 0.269
Data Source: BioPlex,STRINGDB
SGF29
Family: Epigenetic
Novelty: 0.0426456
p_int: 0.883486649
p_ni: 0.116513301
p_wrong: 4.9e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
DENR
Novelty: 0.00653432
p_int: 0.76724615
p_ni: 0.232733832
p_wrong: 0.000020019
Score: 0.189
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Antimicrobial peptides | ||||
Reactome | Immune System | ||||
Reactome | Innate Immune System | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Antimicrobial peptides | ||||
Immune System | ||||
Innate Immune System | ||||
Viral Interactions (0)
Gene Ontology Terms (30)
Components (7)
Processes (23)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Inferred from Sequence or structural Similarity (ISS) | BHF-UCL | |||
Traceable Author Statement (TAS) | Reactome | |||
Inferred from Electronic Annotation (IEA) | GOC | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-SubCell | |||
Disease Associations ()
GWAS Traits (4)
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | ENSG ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|---|
body height | 1 | 1 | 1 | 54.4 | ||||||
body height | 1 | 1 | 1 | 54.4 | ||||||
platelet count | 1 | 1 | 0 | 3.6 | 44.2 | |||||
platelet count | 1 | 1 | 0 | 3.6 | 44.2 | |||||
Items per page:
1 – 4 of 4
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
body height | 1 | 54.4 | |||||
body height | 1 | 54.4 | |||||
platelet count | 0 | 3.6 | 44.2 | ||||
platelet count | 0 | 3.6 | 44.2 | ||||
Find similar targets by:
IDG Resources
Orthologs (12)
1 – 5 of 12
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | chromogranin A | VGNC:13024 | 453120 | |||||
Macaque | chromogranin A | 574388 | ||||||
Mouse | MGI:88394 | 12652 | ||||||
Rat | RGD:2338 | 24258 | ||||||
Horse | chromogranin A | VGNC:49357 | 100033828 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | chromogranin A | |||||
Macaque | chromogranin A | |||||
Mouse | ||||||
Rat | ||||||
Horse | chromogranin A | |||||
Publication Statistics
PubMed Score 2885.89
PubMed score by year
PubTator Score 3416.64
PubTator score by year
Related Publications
Text Mined References (236)
GeneRif Annotations (203)
Items per page:
0 of 0
PMID | Year | Title |
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