Tbio PRKAR1A cAMP-dependent protein kinase type I-alpha regulatory subunit

Protein Summary

Description

Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells. cAMP is a signaling molecule important for a variety of cellular functions. cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins. The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits. cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits. Four different regulatory subunits and three catalytic subunits have been identified in humans. This gene encodes one of the regulatory subunits. This protein was found to be a tissue-specific extinguisher that down-regulates the expression of seven liver genes in hepatoma x fibroblast hybrids. Mutations in this gene cause Carney complex (CNC). This gene can fuse to the RET protooncogene by gene rearrangement and form the thyroid tumor-specific chimeric oncogene known as PTC2. A nonconventional nuclear localization sequence (NLS) has been found for this protein which suggests a role in DNA replication via the protein serving as a nuclear transport protein for the second subunit of the Replication Factor C (RFC40). Several alternatively spliced transcript variants encoding two different isoforms have been observed. [provided by RefSeq, Jan 2013]

Uniprot Accession IDs

• P10644
• K7ER48
• Q567S7

Gene Name

• PRKAR1A

Ensembl ID

• ENST00000358598
• ENSP00000351410
• ENSG00000108946
• ENST00000392711
• ENSP00000376475
• ENST00000536854
• ENSP00000445625
• ENST00000586397
• ENSP00000466459
• ENST00000588188
• ENSP00000468106
• ENST00000589228
• ENSP00000464977

Symbol

• PKR1
• PRKAR1
• TSE1
• CAR
• CNC
• CNC1
• PKR1
• TSE1
• ADOHR
• PPNAD1
• PRKAR1
• ACRDYS1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
biological process	0.99
molecular function	0.97
disease perturbation	0.93
hub protein	0.92

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.78   (req: < 5)

Gene RIFs: 139   (req: <= 3)

Antibodies: 334   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 437.78   (req: >= 5)

Gene RIFs: 139   (req: > 3)

Antibodies: 334   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 21

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0