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Tbio
C7
Complement component C7

Protein Summary
Description
Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor. This gene encodes a serum glycoprotein that forms a membrane attack complex together with complement components C5b, C6, C8, and C9 as part of the terminal complement pathway of the innate immune system. The protein encoded by this gene contains a cholesterol-dependent cytolysin/membrane attack complex/perforin-like (CDC/MACPF) domain and belongs to a large family of structurally related molecules that form pores involved in host immunity and bacterial pathogenesis. This protein initiates membrane attack complex formation by binding the C5b-C6 subcomplex and inserts into the phospholipid bilayer, serving as a membrane anchor. Mutations in this gene are associated with a rare disorder called C7 deficiency. [provided by RefSeq, Nov 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000313164
  • ENSP00000322061
  • ENSG00000112936
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.97
PubMedID
0.86
microRNA
0.65
cell line
0.62
tissue
0.52


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.29   (req: < 5)
Gene RIFs: 23   (req: <= 3)
Antibodies: 255   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 62.29   (req: >= 5)
Gene RIFs: 23   (req: > 3)
Antibodies: 255   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
complement C7
VGNC:3924
738238
Macaque
complement C7
696926
Mouse
MGI:88235
109828
Rat
RGD:620318
117517
Dog
complement C7
VGNC:38599
489221
Species
Name
OMA
EggNOG
Inparanoid
Chimp
complement C7
Macaque
complement C7
Mouse
Rat
Dog
complement C7
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10643-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (13)
Complement cascade (R-HSA-166658)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 5
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Complement cascade
Reactome
Immune System
Reactome
Innate Immune System
Reactome
Regulation of Complement cascade
Reactome
Terminal pathway of complement
Name
Explore in Pharos
Explore in Source
Complement cascade
Immune System
Innate Immune System
Regulation of Complement cascade
Terminal pathway of complement
Gene Ontology Terms (9)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Traceable Author Statement (TAS)
Reactome
Protein-Protein Interactions (45)
1 – 10 of 45
C5
Tclin
Novelty: 0.00225386
Score: 0.968
Data Source: Reactome,STRINGDB
CFP
Tbio
Novelty: 0.00063251
Score: 0.962
Data Source: STRINGDB
CLU
Tbio
Novelty: 0.00054776
Score: 0.947
Data Source: Reactome,STRINGDB
C6
Tbio
Novelty: 0.0132784
Score: 0.924
Data Source: Reactome,STRINGDB
C8G
Tbio
Novelty: 0.02322575
Score: 0.917
Data Source: Reactome,STRINGDB
VTN
Tbio
Family: TF
Novelty: 0.00046861
Score: 0.917
Data Source: Reactome,STRINGDB
CD59
Tbio
Novelty: 0.0008352
Score: 0.916
Data Source: Reactome,STRINGDB
C9
Tbio
Novelty: 0.00749298
Score: 0.915
Data Source: Reactome,STRINGDB
C8A
Tbio
Novelty: 0.00429321
Score: 0.913
Data Source: Reactome,STRINGDB
C8B
Tbio
Novelty: 0.00873524
Score: 0.907
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  62.29

PubMed score by year
PubTator Score  739.28

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer