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Tclin
MAPT
Microtubule-associated protein tau

Protein Summary
Description
Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by TAU/MAPT localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontot ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000262410
  • ENSP00000262410
  • ENSG00000186868
  • ENST00000334239
  • ENSP00000334886
  • ENST00000340799
  • ENSP00000340438
  • ENST00000344290
  • ENSP00000340820
  • ENST00000351559
  • ENSP00000303214
  • ENST00000415613
  • ENSP00000410838
  • ENST00000420682
  • ENSP00000413056
  • ENST00000431008
  • ENSP00000389250
  • ENST00000446361
  • ENSP00000408975
  • ENST00000535772
  • ENSP00000443028
  • ENST00000571987
  • ENSP00000458742
  • ENST00000574436
  • ENSP00000460965
  • ENST00000612872
  • ENSP00000478602
  • ENSG00000277956
  • ENST00000613360
  • ENSP00000483784
  • ENSG00000276155
  • ENST00000620070
  • ENSP00000484491
  • ENST00000620818
  • ENSP00000484321
  • ENST00000620981
  • ENSP00000481769
  • ENST00000621329
  • ENSP00000477703
  • ENST00000622106
  • ENSP00000482244
  • ENST00000622728
  • ENSP00000479142
  • ENST00000626571
  • ENSP00000486039
  • ENST00000628393
  • ENSP00000487570
  • ENST00000631447
  • ENSP00000488373
  • ENST00000632500
  • ENSP00000487837
  • ENST00000633047
  • ENSP00000488245
  • ENST00000634049
  • ENSP00000487819

Symbol
  • MAPTL
  • MTBT1
  • TAU
  • TAU
  • MSTD
  • PPND
  • DDPAC
  • MAPTL
  • MTBT1
  • MTBT2
  • FTDP-17
  • PPP1R103
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
hub protein
1
kinase
1
phosphatase
0.99
PubMedID
0.99


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9015.14   (req: < 5)
Gene RIFs: 1252   (req: <= 3)
Antibodies: 4894   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 9015.14   (req: >= 5)
Gene RIFs: 1252   (req: > 3)
Antibodies: 4894   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 81
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 120
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2