Tclin CYP2D6 Cytochrome P450 2D6

Protein Summary

Description

Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein since they carry 2 null alleles whereas in other individuals the gene is absent. This gene can vary in copy number and individuals with the ultrarapid metabolizer phenotype can have 3 or more active copies of the gene. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

Uniprot Accession IDs

• P10635
• Q16752
• Q2XND6
• Q2XND7
• Q2XNE0
• Q6B012
• Q6NXU8

Gene Name

• CYP2D6

Ensembl ID

• ENST00000359033
• ENSP00000351927
• ENSG00000100197
• ENST00000360608
• ENSP00000353820
• ENST00000612990
• ENSP00000483677
• ENSG00000275211
• ENST00000645361
• ENSP00000496150
• ENST00000645508
• ENSP00000496296

Symbol

• CYP2DL1
• CPD6
• CYP2D
• CYP2DL1
• CYPIID6
• P450C2D
• P450DB1
• CYP2D7AP
• CYP2D7BP
• CYP2D7P2
• CYP2D8P2
• P450-DB1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
biological term	1
chemical	1
disease	1
drug	1
co-expressed gene	0.98

Protein Classes

No PANTHER Classes or DTO Classes found

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5625.95   (req: < 5)

Gene RIFs: 640   (req: <= 3)

Antibodies: 570   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 5625.95   (req: >= 5)

Gene RIFs: 640   (req: > 3)

Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1238

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 58