Protein Summary
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein sinc ...more
- ENST00000359033
- ENSP00000351927
- ENSG00000100197
- ENST00000360608
- ENSP00000353820
- ENST00000612990
- ENSP00000483677
- ENSG00000275211
- ENST00000645361
- ENSP00000496150
- ENST00000645508
- ENSP00000496296
- CYP2DL1
- CPD6
- CYP2D
- CYP2DL1
- CYPIID6
- P450C2D
- P450DB1
- CYP2D7AP
- CYP2D7BP
- CYP2D7P2
- CYP2D8P2
- P450-DB1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
disease | 1 | ||
drug | 1 | ||
co-expressed gene | 0.98 | ||
Related Tools
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4929.59 (req: < 5)
Gene RIFs: 545 (req: <= 3)
Antibodies: 570 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 4929.59 (req: >= 5)
Gene RIFs: 545 (req: > 3)
Antibodies: 570 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 25
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 30
Approved Drugs (30)
1 – 10 of 30
Active Ligands (25)
1 – 10 of 25
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 2, subfamily D, polypeptide 6 | 470228 | ||||||
Macaque | cytochrome P450 2D17-like | 100424965 | ||||||
Mouse | MGI:1929474 | 56448 | ||||||
Rat | RGD:620640 | 171522 | ||||||
Horse | cytochrome P450 2D50 | 100070945 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 2, subfamily D, polypeptide 6 | |||||
Macaque | cytochrome P450 2D17-like | |||||
Mouse | ||||||
Rat | ||||||
Horse | cytochrome P450 2D50 | |||||
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id | Ligand | Method | Resolution (Å) | M.W. (kDa) | Pub Year | Title |
|---|
PDB Structure Id | M.W. | Resolution | Pub Year |
|---|
Pathways (26)
Reactome (13)
KEGG (4)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Items per page:
1 – 5 of 13
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of maresin-like SPMs | ||||
Reactome | Biosynthesis of maresins | ||||
Reactome | Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of maresin-like SPMs | ||||
Biosynthesis of maresins | ||||
Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Gene Ontology Terms (32)
Functions (8)
Components (6)
Processes (18)
Items per page:
10
1 – 8 of 8
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Protein-Protein Interactions (107)
1 – 10 of 107
FMO3
Family: Enzyme
Novelty: 0.00567911
Score: 0.961
Data Source: STRINGDB
FMO1
Family: Enzyme
Novelty: 0.02090294
Score: 0.959
Data Source: STRINGDB
MAOA
Family: Enzyme
Novelty: 0.00031037
Score: 0.951
Data Source: STRINGDB
FMO5
Family: Enzyme
Novelty: 0.05610368
Score: 0.948
Data Source: STRINGDB
CYP3A4
Family: Enzyme
Novelty: 0.00015515
Score: 0.948
Data Source: STRINGDB
MAOB
Family: Enzyme
Novelty: 0.00030366
Score: 0.946
Data Source: STRINGDB
CBR3
Family: Enzyme
Novelty: 0.01874422
Score: 0.937
Data Source: STRINGDB
FMO2
Family: Enzyme
Novelty: 0.02880294
Score: 0.93
Data Source: STRINGDB
FMO4
Family: Enzyme
Novelty: 0.0411802
Score: 0.929
Data Source: STRINGDB
HSD11B1
Family: Enzyme
Novelty: 0.00105097
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score 4929.59
PubMed score by year
PubTator Score 3352.79
PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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