Protein Summary
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein sinc ...more
- ENST00000359033
- ENSP00000351927
- ENSG00000100197
- ENST00000360608
- ENSP00000353820
- ENST00000612990
- ENSP00000483677
- ENSG00000275211
- ENST00000645361
- ENSP00000496150
- ENST00000645508
- ENSP00000496296
- CYP2DL1
- CPD6
- CYP2D
- CYP2DL1
- CYPIID6
- P450C2D
- P450DB1
- CYP2D7AP
- CYP2D7BP
- CYP2D7P2
- CYP2D8P2
- P450-DB1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
disease | 1 | ||
drug | 1 | ||
co-expressed gene | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5625.95 (req: < 5)
Gene RIFs: 654 (req: <= 3)
Antibodies: 570 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5625.95 (req: >= 5)
Gene RIFs: 654 (req: > 3)
Antibodies: 570 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1238
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 58