Protein Summary
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein sinc ...more
- ENST00000359033
- ENSP00000351927
- ENSG00000100197
- ENST00000360608
- ENSP00000353820
- ENST00000612990
- ENSP00000483677
- ENSG00000275211
- ENST00000645361
- ENSP00000496150
- ENST00000645508
- ENSP00000496296
- CYP2DL1
- CPD6
- CYP2D
- CYP2DL1
- CYPIID6
- P450C2D
- P450DB1
- CYP2D7AP
- CYP2D7BP
- CYP2D7P2
- CYP2D8P2
- P450-DB1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological term | 1 | ||
chemical | 1 | ||
disease | 1 | ||
drug | 1 | ||
co-expressed gene | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5035.54 (req: < 5)
Gene RIFs: 545 (req: <= 3)
Antibodies: 570 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 5035.54 (req: >= 5)
Gene RIFs: 545 (req: > 3)
Antibodies: 570 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 26
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1220
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 58
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (58)
Active Ligands (1220)
Protein-Protein Interactions (107)
Nearest Tclin Targets
Pathways (26)
Reactome (13)
KEGG (4)
PathwayCommons (1)
WikiPathways (8)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Biological oxidations | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of maresin-like SPMs | ||||
Reactome | Biosynthesis of maresins | ||||
Reactome | Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Biological oxidations | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of maresin-like SPMs | ||||
Biosynthesis of maresins | ||||
Biosynthesis of specialized proresolving mediators (SPMs) | ||||
Viral Interactions (0)
Gene Ontology Terms (32)
Functions (8)
Components (6)
Processes (18)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (12)
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
intelligence | 6 | 6 | 2 | 6.3 | 84.3 | ||||
8 | 4 | 3 | 1.1 | 82.5 | |||||
self reported educational attainment | 2 | 2 | 2 | 76.2 | |||||
cognitive function measurement | 1 | 1 | 1 | 66.3 | |||||
mathematical ability | 2 | 2 | 2 | 63 | |||||
Items per page:
1 – 5 of 12
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
intelligence | 2 | 6.3 | 84.3 | ||||
3 | 1.1 | 82.5 | |||||
self reported educational attainment | 2 | 76.2 | |||||
cognitive function measurement | 1 | 66.3 | |||||
mathematical ability | 2 | 63 | |||||
Find similar targets by:
IDG Resources
Orthologs (7)
1 – 5 of 7
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 2, subfamily D, polypeptide 6 | 470228 | ||||||
Macaque | cytochrome P450 2D17-like | 100424965 | ||||||
Mouse | MGI:1929474 | 56448 | ||||||
Rat | RGD:620640 | 171522 | ||||||
Horse | cytochrome P450 2D50 | 100070945 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450, family 2, subfamily D, polypeptide 6 | |||||
Macaque | cytochrome P450 2D17-like | |||||
Mouse | ||||||
Rat | ||||||
Horse | cytochrome P450 2D50 | |||||
Publication Statistics
PubMed Score 5035.54
PubMed score by year
PubTator Score 3352.79
PubTator score by year
Related Publications
Text Mined References (949)
GeneRif Annotations (545)
Items per page:
0 of 0
PMID | Year | Title |
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