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Tclin
CYP2D6
Cytochrome P450 2D6

Protein Summary
Description
Responsible for the metabolism of many drugs and environmental chemicals that it oxidizes. It is involved in the metabolism of drugs such as antiarrhythmics, adrenoceptor antagonists, and tricyclic antidepressants. This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is known to metabolize as many as 25% of commonly prescribed drugs. Its substrates include antidepressants, antipsychotics, analgesics and antitussives, beta adrenergic blocking agents, antiarrythmics and antiemetics. The gene is highly polymorphic in the human population; certain alleles result in the poor metabolizer phenotype, characterized by a decreased ability to metabolize the enzyme's substrates. Some individuals with the poor metabolizer phenotype have no functional protein sinc ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359033
  • ENSP00000351927
  • ENSG00000100197
  • ENST00000360608
  • ENSP00000353820
  • ENST00000612990
  • ENSP00000483677
  • ENSG00000275211
  • ENST00000645361
  • ENSP00000496150
  • ENST00000645508
  • ENSP00000496296

Symbol
  • CYP2DL1
  • CPD6
  • CYP2D
  • CYP2DL1
  • CYPIID6
  • P450C2D
  • P450DB1
  • CYP2D7AP
  • CYP2D7BP
  • CYP2D7P2
  • CYP2D8P2
  • P450-DB1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological term
1
chemical
1
disease
1
drug
1
co-expressed gene
0.98


Related Tools
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4929.59   (req: < 5)
Gene RIFs: 545   (req: <= 3)
Antibodies: 570   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 4929.59   (req: >= 5)
Gene RIFs: 545   (req: > 3)
Antibodies: 570   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 26
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 25
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 30
Orthologs (7)
1 – 5 of 7
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 2, subfamily D, polypeptide 6
470228
Macaque
cytochrome P450 2D17-like
100424965
Mouse
MGI:1929474
56448
Rat
RGD:620640
171522
Horse
cytochrome P450 2D50
100070945
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450, family 2, subfamily D, polypeptide 6
Macaque
cytochrome P450 2D17-like
Mouse
Rat
Horse
cytochrome P450 2D50
Protein Data Bank (12)
1 – 5 of 12
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (26)
Biological oxidations (R-HSA-211859)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 13
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresin-like SPMs
Reactome
Biosynthesis of maresins
Reactome
Biosynthesis of specialized proresolving mediators (SPMs)
Name
Explore in Pharos
Explore in Source
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresin-like SPMs
Biosynthesis of maresins
Biosynthesis of specialized proresolving mediators (SPMs)
Gene Ontology Terms (32)
Items per page:
10
1 – 8 of 8
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (107)
1 – 10 of 107
FMO3
Tbio
Family: Enzyme
Novelty: 0.00567911
Score: 0.961
Data Source: STRINGDB
FMO1
Tbio
Family: Enzyme
Novelty: 0.02090294
Score: 0.959
Data Source: STRINGDB
MAOA
Tclin
Family: Enzyme
Novelty: 0.00031037
Score: 0.951
Data Source: STRINGDB
FMO5
Tbio
Family: Enzyme
Novelty: 0.05610368
Score: 0.948
Data Source: STRINGDB
CYP3A4
Tclin
Family: Enzyme
Novelty: 0.00015515
Score: 0.948
Data Source: STRINGDB
MAOB
Tclin
Family: Enzyme
Novelty: 0.00030366
Score: 0.946
Data Source: STRINGDB
CBR3
Tbio
Family: Enzyme
Novelty: 0.01874422
Score: 0.937
Data Source: STRINGDB
FMO2
Tbio
Family: Enzyme
Novelty: 0.02880294
Score: 0.93
Data Source: STRINGDB
FMO4
Tbio
Family: Enzyme
Novelty: 0.0411802
Score: 0.929
Data Source: STRINGDB
HSD11B1
Tclin
Family: Enzyme
Novelty: 0.00105097
Score: 0.928
Data Source: STRINGDB
Publication Statistics
PubMed Score  4929.59

PubMed score by year
PubTator Score  3352.79

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer