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Tchem
CYP2C8
Cytochrome P450 2C8

Protein Summary
Description
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000371270
  • ENSP00000360317
  • ENSG00000138115
  • ENST00000535898
  • ENSP00000445062

Symbol
  • CPC8
  • CYPIIC8
  • CYP2C8DM
  • MP-12/MP-20
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
drug
1
chemical
0.97
disease
0.83
biological term
0.82
molecular function
0.81


Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.98   (req: < 5)
Gene RIFs: 121   (req: <= 3)
Antibodies: 200   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 538.98   (req: >= 5)
Gene RIFs: 121   (req: > 3)
Antibodies: 200   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 20
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 47
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3
Active Ligands (47)
1 – 10 of 47
GWAS Traits (6)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
1
3
4
94.5
testosterone measurement
2
2
2
73.4
serum metabolite measurement
1
1
1
73.2
appendicular lean mass
1
2
2
68.4
response to anticoagulant
1
1
0
6.2
17.3
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood metabolite measurement
4
94.5
testosterone measurement
2
73.4
serum metabolite measurement
1
73.2
appendicular lean mass
2
68.4
response to anticoagulant
0
6.2
17.3
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily C member 8
VGNC:6150
450909
Macaque
cytochrome P450, family 2, subfamily C, polypeptide 8
678683
Anole lizard
cytochrome P450 2C5
100561707
Species
Name
OMA
EggNOG
Inparanoid
Chimp
cytochrome P450 family 2 subfamily C member 8
Macaque
cytochrome P450, family 2, subfamily C, polypeptide 8
Anole lizard
cytochrome P450 2C5
Protein Structure (5 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10632-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 5
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (30)
Arachidonic acid metabolism (R-HSA-2142753)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Arachidonic acid metabolism
Reactome
Biological oxidations
Reactome
Biosynthesis of DHA-derived SPMs
Reactome
Biosynthesis of maresin-like SPMs
Reactome
Biosynthesis of maresins
Name
Explore in Pharos
Explore in Source
Arachidonic acid metabolism
Biological oxidations
Biosynthesis of DHA-derived SPMs
Biosynthesis of maresin-like SPMs
Biosynthesis of maresins
Gene Ontology Terms (24)
Items per page:
10
1 – 9 of 9
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Direct Assay (IDA)
BHF-UCL
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
UniProtKB-EC
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (132)
1 – 10 of 132
EPHX1
Tchem
Family:  Enzyme
Novelty:  0.00220169
Score:  0.949
Data Source:  STRINGDB
EPHX2
Tchem
Family:  Enzyme
Novelty:  0.00430741
Score:  0.949
Data Source:  STRINGDB
CYP3A4
Tclin
Family:  Enzyme
Novelty:  0.00015515
Score:  0.948
Data Source:  STRINGDB
CYP4A11
Tbio
Novelty:  0.01121493
Score:  0.944
Data Source:  STRINGDB
CYP4F2
Tchem
Family:  Enzyme
Novelty:  0.0050361
Score:  0.937
Data Source:  STRINGDB
CYP4F3
Tbio
Family:  Enzyme
Novelty:  0.01392719
Score:  0.933
Data Source:  STRINGDB
PTGS2
Tclin
Family:  Enzyme
Novelty:  0.00007089
Score:  0.93
Data Source:  STRINGDB
CYP1A2
Tchem
Novelty:  0.00034756
Score:  0.928
Data Source:  STRINGDB
CYP4F8
Tbio
Novelty:  0.06814051
Score:  0.926
Data Source:  STRINGDB
CYP1A1
Tchem
Novelty:  0.0002404
Score:  0.924
Data Source:  STRINGDB
Publication Statistics
PubMed Score  538.98

PubMed score by year
PubTator Score  435.9

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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