Protein Summary
Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics. In the epoxidation of arachidonic acid it generates only 14,15- and 11,12-cis-epoxyeicosatrienoic acids. It is the principal enzyme responsible for the metabolism the anti-cancer drug paclitaxel (taxol). This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within ...more
- ENST00000371270
- ENSP00000360317
- ENSG00000138115
- ENST00000535898
- ENSP00000445062
- CPC8
- CYPIIC8
- CYP2C8DM
- MP-12/MP-20
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
drug | 1 | ||
chemical | 0.97 | ||
disease | 0.83 | ||
biological term | 0.82 | ||
molecular function | 0.81 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 538.98 (req: < 5)
Gene RIFs: 121 (req: <= 3)
Antibodies: 200 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 538.98 (req: >= 5)
Gene RIFs: 121 (req: > 3)
Antibodies: 200 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 20
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 47
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (47)
Protein-Protein Interactions (132)
Nearest Tclin Targets (9)
Upstream (3)
Downstream (6)
1 – 3 of 3
Pathways (30)
Reactome (15)
KEGG (7)
PathwayCommons (1)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Arachidonic acid metabolism | ||||
Reactome | Biological oxidations | ||||
Reactome | Biosynthesis of DHA-derived SPMs | ||||
Reactome | Biosynthesis of maresin-like SPMs | ||||
Reactome | Biosynthesis of maresins | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Arachidonic acid metabolism | ||||
Biological oxidations | ||||
Biosynthesis of DHA-derived SPMs | ||||
Biosynthesis of maresin-like SPMs | ||||
Biosynthesis of maresins | ||||
Viral Interactions (0)
Gene Ontology Terms (24)
Functions (9)
Components (4)
Processes (11)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Biological aspect of Ancestor (IBA) | GO_Central | |||
Inferred from Electronic Annotation (IEA) | UniProtKB-EC | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (6)
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
blood metabolite measurement | 1 | 3 | 4 | 94.5 | |||||
testosterone measurement | 2 | 2 | 2 | 73.4 | |||||
serum metabolite measurement | 1 | 1 | 1 | 73.2 | |||||
appendicular lean mass | 1 | 2 | 2 | 68.4 | |||||
response to anticoagulant | 1 | 1 | 0 | 6.2 | 17.3 | ||||
Items per page:
1 – 5 of 6
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
blood metabolite measurement | 4 | 94.5 | |||||
testosterone measurement | 2 | 73.4 | |||||
serum metabolite measurement | 1 | 73.2 | |||||
appendicular lean mass | 2 | 68.4 | |||||
response to anticoagulant | 0 | 6.2 | 17.3 | ||||
Find similar targets by:
IDG Resources
Orthologs (3)
1 – 3 of 3
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily C member 8 | VGNC:6150 | 450909 | |||||
Macaque | cytochrome P450, family 2, subfamily C, polypeptide 8 | 678683 | ||||||
Anole lizard | cytochrome P450 2C5 | 100561707 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | cytochrome P450 family 2 subfamily C member 8 | |||||
Macaque | cytochrome P450, family 2, subfamily C, polypeptide 8 | |||||
Anole lizard | cytochrome P450 2C5 | |||||
Publication Statistics
PubMed Score 538.98
PubMed score by year
PubTator Score 435.90
PubTator score by year
Related Publications
Text Mined References (204)
GeneRif Annotations (121)
Items per page:
0 of 0
PMID | Year | Title |
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