You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
MGST1
Microsomal glutathione S-transferase 1

Protein Summary
Description
Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Has a wide substrate specificity. The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by R ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000010404
  • ENSP00000010404
  • ENSG00000008394
  • ENST00000396207
  • ENSP00000379510
  • ENST00000396209
  • ENSP00000379512
  • ENST00000396210
  • ENSP00000379513
  • ENST00000535309
  • ENSP00000438308

Symbol
  • GST12
  • MGST
  • MGST
  • GST12
  • MGST-I
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
small molecule perturbation
1
transcription factor perturbation
1
virus perturbation
0.97
PubMedID
0.82
molecular function
0.79


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.83   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 204   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.83   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 204   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (141)
MGST3
Tbio
Family:  Enzyme
Novelty:  0.02891864
Score:  0.932
Data Source:  STRINGDB
MGST2
Tbio
Family:  Enzyme
Novelty:  0.04976733
Score:  0.93
Data Source:  STRINGDB
VNN1
Tchem
Family:  Enzyme
Novelty:  0.0144646
Score:  0.912
Data Source:  STRINGDB
LAMP1
Tbio
Novelty:  0.00067563
Score:  0.908
Data Source:  STRINGDB
LAMP2
Tbio
Novelty:  0.00168009
Score:  0.904
Data Source:  STRINGDB
LPCAT1
Tbio
Family:  Enzyme
Novelty:  0.01441133
Score:  0.903
Data Source:  STRINGDB
VAMP8
Tbio
Novelty:  0.01083228
Score:  0.903
Data Source:  STRINGDB
STOM
Tbio
Novelty:  0.00459891
Score:  0.903
Data Source:  STRINGDB
FPR1
Tchem
Family:  GPCR
Novelty:  0.00256884
Score:  0.902
Data Source:  STRINGDB
GGH
Tchem
Family:  Enzyme
Novelty:  0.00258239
Score:  0.902
Data Source:  STRINGDB
Nearest Tclin Targets (7)
Explore Nearest Tclin Targets
Pathways (23)
Aflatoxin activation and detoxification (R-HSA-5423646)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Aflatoxin activation and detoxification
Reactome
Biological oxidations
Reactome
Glutathione conjugation
Reactome
Immune System
Reactome
Innate Immune System
Name
Explore in Pharos
Explore in Source
Aflatoxin activation and detoxification
Biological oxidations
Glutathione conjugation
Immune System
Innate Immune System
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (9)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
2
2
71.6
self reported educational attainment
1
2
2
70.4
smoking cessation
1
1
1
54.4
mathematical ability
1
1
1
45.2
cigarettes per day measurement
1
1
1
44.2
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
smoking status measurement
2
71.6
self reported educational attainment
2
70.4
smoking cessation
1
54.4
mathematical ability
1
45.2
cigarettes per day measurement
1
44.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 1
VGNC:5475
740580
Macaque
microsomal glutathione S-transferase 1
701652
Mouse
MGI:1913850
56615
Rat
RGD:70927
171341
Dog
microsomal glutathione S-transferase 1
VGNC:43215
477683
Species
Name
OMA
EggNOG
Inparanoid
Chimp
microsomal glutathione S-transferase 1
Macaque
microsomal glutathione S-transferase 1
Mouse
Rat
Dog
microsomal glutathione S-transferase 1
Publication Statistics
PubMed Score 147.83
PubMed score by year
PubTator Score 66.09
PubTator score by year
loading...
Related Publications
Items per page:
0 of 0
PMID
Year
Title