Tchem CTSA Lysosomal protective protein

Protein Summary

Description

Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]

Uniprot Accession IDs

• P10619
• B2R798
• Q561W6
• Q5JZH1
• Q96KJ2
• Q9BR08
• Q9BW68

Gene Name

• CTSA

Ensembl ID

• ENST00000191018
• ENSP00000191018
• ENSG00000064601
• ENST00000372459
• ENSP00000361537
• ENST00000646241
• ENSP00000493613

Symbol

• PPGB
• GSL
• GLB2
• NGBE
• PPCA
• PPGB

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
kinase perturbation	1
interacting protein	0.98
transcription factor perturbation	0.94
disease perturbation	0.83
cellular component	0.8

Protein Classes

PANTHER Classes

Protein / Hydrolase / Protease / Serine Protease / Lysosomal Protective Protein

DTO Classes

Protein / Enzyme / Protease / Serine Protease / Lysosomal Protective Protein

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 708.88   (req: < 5)

Gene RIFs: 22   (req: <= 3)

Antibodies: 423   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 708.88   (req: >= 5)

Gene RIFs: 22   (req: > 3)

Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 402

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2