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Tchem
CTSA
Lysosomal protective protein

Protein Summary
Description
Protective protein appears to be essential for both the activity of beta-galactosidase and neuraminidase, it associates with these enzymes and exerts a protective function necessary for their stability and activity. This protein is also a carboxypeptidase and can deamidate tachykinins. This gene encodes a member of the peptidase S10 family of serine carboxypeptidases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate two chains that comprise the heterodimeric active enzyme. This enzyme possesses deamidase, esterase and carboxypeptidase activities and acts as a scaffold in the lysosomal multienzyme complex. Mutations in this gene are associated with galactosialidosis. [provided by RefSeq, Nov 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000191018
  • ENSP00000191018
  • ENSG00000064601
  • ENST00000372459
  • ENSP00000361537
  • ENST00000646241
  • ENSP00000493613

Symbol
  • PPGB
  • GSL
  • GLB2
  • NGBE
  • PPCA
  • PPGB
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
kinase perturbation
1
interacting protein
0.98
transcription factor perturbation
0.94
disease perturbation
0.83
cellular component
0.8


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.26   (req: < 5)
Gene RIFs: 14   (req: <= 3)
Antibodies: 423   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 569.26   (req: >= 5)
Gene RIFs: 14   (req: > 3)
Antibodies: 423   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 12
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 402
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (402)
3,4-dichloroisocoumarin
Rendered image for 3,4-dichloroisocoumarin
CHEMBL3145341
Rendered image for CHEMBL3145341
CHEMBL2171398
Rendered image for CHEMBL2171398
CHEMBL2171397
Rendered image for CHEMBL2171397
CHEMBL2171396
Rendered image for CHEMBL2171396
example 166 [WO2014154727]
Rendered image for example 166  [WO2014154727]
US9150526, 205
Rendered image for US9150526, 205
CHEMBL2171390
Rendered image for CHEMBL2171390
US9150526, 222
Rendered image for US9150526, 222
CHEMBL2171392
Rendered image for CHEMBL2171392
Protein-Protein Interactions (223)
KLHDC9
Tbio
Novelty:  1.56875574
p_int:  0.993302053
p_ni:  0.006697947
Score:  0.357
Data Source:  BioPlex,STRINGDB
PHF8
Tchem
Family:  Epigenetic
Novelty:  0.01946151
p_int:  0.971659263
p_ni:  0.028340737
Data Source:  BioPlex
SFXN5
Tdark
Novelty:  0.30379915
p_int:  0.953156301
p_ni:  0.046843699
Score:  0.188
Data Source:  BioPlex,STRINGDB
C9orf40
Tdark
Novelty:  2.72763898
p_int:  0.946215996
p_ni:  0.053784004
Data Source:  BioPlex
RHOA
Tbio
Family:  Enzyme
Novelty:  0.00022204
p_int:  0.874201976
p_ni:  0.125798024
Score:  0.643
Data Source:  BioPlex,STRINGDB
DNAJB2
Tbio
Novelty:  0.046216
p_int:  0.85931443
p_ni:  0.140685568
p_wrong:  2e-9
Score:  0.255
Data Source:  BioPlex,STRINGDB
RORC
Tchem
Family:  NR
Novelty:  0.00509106
p_int:  0.804071954
p_ni:  0.195928045
p_wrong:  1e-9
Score:  0.368
Data Source:  BioPlex,STRINGDB
RHOC
Tbio
Family:  Enzyme
Novelty:  0.00262213
p_int:  0.775450041
p_ni:  0.224549959
Score:  0.809
Data Source:  BioPlex,STRINGDB
GLB1
Tchem
Family:  Enzyme
Novelty:  0.00241713
Score:  0.993
Data Source:  Reactome,STRINGDB
NEU1
Tchem
Family:  Enzyme
Novelty:  0.00479879
Score:  0.987
Data Source:  Reactome,STRINGDB
Nearest Tclin Targets
Nearest Tclin calculations are only available for targets with KEGG Pathway annotations.
Pathways (22)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 19
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Asparagine N-linked glycosylation
Reactome
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Reactome
Defective NEU1 causes sialidosis
Reactome
Disease
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Asparagine N-linked glycosylation
Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
Defective NEU1 causes sialidosis
Disease
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (34)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
15
15
26
99.7
triglyceride measurement
14
12
24
3.3
99.4
sleep duration
4
3
4
90.1
apolipoprotein B measurement
2
2
2
86.8
blood metabolite measurement
1
2
2
86
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
high density lipoprotein cholesterol measurement
26
99.7
triglyceride measurement
24
3.3
99.4
sleep duration
4
90.1
apolipoprotein B measurement
2
86.8
blood metabolite measurement
2
86
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Macaque
cathepsin A
708592
Mouse
MGI:97748
19025
Rat
RGD:1309070
296370
Dog
cathepsin A
VGNC:39708
611146
Horse
cathepsin A
VGNC:16947
100071127
Species
Name
OMA
EggNOG
Inparanoid
Macaque
cathepsin A
Mouse
Rat
Dog
cathepsin A
Horse
cathepsin A
Publication Statistics
PubMed Score 569.26
PubMed score by year
PubTator Score 365.65
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title