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Tchem
TXN
Thioredoxin

Protein Summary
Description
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374515
  • ENSP00000363639
  • ENSG00000136810
  • ENST00000374517
  • ENSP00000363641

Symbol
  • TRDX
  • TRX
  • TRX1
  • TRX
  • TRDX
  • TRX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
biological process
0.98
hub protein
0.98
transcription factor perturbation
0.98


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1622.67   (req: < 5)
Gene RIFs: 235   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1622.67   (req: >= 5)
Gene RIFs: 235   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (39)
1 – 5 of 39
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
FOXO-mediated transcription
Protein-Protein Interactions (366)
1 – 10 of 366
CHCHD4
Tbio
Novelty: 0.01246396
p_int: 0.99538692
p_ni: 0.00461308
Score: 0.486
Data Source: BioPlex,STRINGDB
TXNIP
Tbio
Novelty: 0.00279977
p_int: 0.849381742
p_ni: 0.150618258
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00387669
Score: 0.999
Data Source: Reactome,STRINGDB
PRDX1
Tbio
Novelty: 0.00234504
Score: 0.994
Data Source: Reactome,STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00192027
Score: 0.994
Data Source: Reactome,STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00044941
Score: 0.993
Data Source: STRINGDB
PRDX2
Tbio
Novelty: 0.00236489
Score: 0.99
Data Source: Reactome,STRINGDB
MSRA
Tbio
Family: Enzyme
Novelty: 0.00941816
Score: 0.986
Data Source: Reactome,STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00057594
Score: 0.984
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00002203
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  1622.67

PubMed score by year
PubTator Score  1990.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer