Protein Summary
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants ...more
- ENST00000374515
- ENSP00000363639
- ENSG00000136810
- ENST00000374517
- ENSP00000363641
- TRDX
- TRX
- TRX1
- TRX
- TRDX
- TRX1
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
disease perturbation | 1 | ||
interacting protein | 1 | ||
biological process | 0.98 | ||
hub protein | 0.98 | ||
transcription factor perturbation | 0.98 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1727.35 (req: < 5)
Gene RIFs: 235 (req: <= 3)
Antibodies: 714 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1727.35 (req: >= 5)
Gene RIFs: 235 (req: > 3)
Antibodies: 714 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 18
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 8
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (8)
Protein-Protein Interactions (366)
CHCHD4
Novelty: 0.01204944
p_int: 0.99538692
p_ni: 0.00461308
Score: 0.486
Data Source: BioPlex,STRINGDB
TXNIP
Novelty: 0.00216952
p_int: 0.849381742
p_ni: 0.150618258
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
Nearest Tclin Targets
Pathways (37)
Reactome (22)
KEGG (2)
PathwayCommons (6)
WikiPathways (7)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Cellular Senescence | ||||
Reactome | Cellular responses to external stimuli | ||||
Reactome | Cellular responses to stress | ||||
Reactome | Detoxification of Reactive Oxygen Species | ||||
Reactome | FOXO-mediated transcription | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Cellular Senescence | ||||
Cellular responses to external stimuli | ||||
Cellular responses to stress | ||||
Detoxification of Reactive Oxygen Species | ||||
FOXO-mediated transcription | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (3)
Components (3)
Processes (15)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from High Throughput Direct Assay (HDA) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Inferred from Electronic Annotation (IEA) | InterPro | |||
Disease Associations ()
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 1 | 1 | 53.3 | |||||
mean reticulocyte volume | 1 | 1 | 1 | 45.7 | |||||
platelet crit | 1 | 1 | 1 | 31.4 | |||||
sex hormone-binding globulin measurement | 6 | 1 | 6 | 29.9 | |||||
urate measurement | 1 | 1 | 1 | 5.2 | |||||
Items per page:
1 – 5 of 5
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
mean corpuscular hemoglobin concentration | 1 | 53.3 | |||||
mean reticulocyte volume | 1 | 45.7 | |||||
platelet crit | 1 | 31.4 | |||||
sex hormone-binding globulin measurement | 6 | 29.9 | |||||
urate measurement | 1 | 5.2 | |||||
Find similar targets by:
IDG Resources
Orthologs (14)
1 – 5 of 14
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | thioredoxin | VGNC:4894 | 740248 | |||||
Macaque | thioredoxin | 712587 | ||||||
Mouse | MGI:98874 | 22166 | ||||||
Rat | RGD:621157 | 116484 | ||||||
Horse | thioredoxin | 100033827 | ||||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | thioredoxin | |||||
Macaque | thioredoxin | |||||
Mouse | ||||||
Rat | ||||||
Horse | thioredoxin | |||||
Publication Statistics
PubMed Score 1727.35
PubMed score by year
PubTator Score 1990.20
PubTator score by year
Related Publications
Text Mined References (288)
GeneRif Annotations (235)
Items per page:
0 of 0
PMID | Year | Title |
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