Tchem TXN Thioredoxin

Protein Classes

DTO Classes

Thioredoxin, Mitochondrial / Thioredoxin-dependent Peroxide Reductase, Mitochondrial / Thioredoxin Domain-containing Protein 12 / Thioredoxin Reductase 2, Mitochondrial / Thioredoxin Reductase 3 / Thioredoxin Reductase 1, Cytoplasmic / Thioredoxin Domain-containing Protein 9 / Thioredoxin Domain-containing Protein 17

Protein Summary

Description

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P10599
• B1ALW1
• O60744
• Q53X69
• Q96KI3
• Q9UDG5
• Trx

Gene Name

• TXN

Ensembl ID

• ENST00000374515
• ENSP00000363639
• ENSG00000136810
• ENST00000374517
• ENSP00000363641

Symbol

• TRDX
• TRX
• TRX1
• TRX
• TRDX
• TRX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
biological process	0.98
hub protein	0.98
transcription factor perturbation	0.98

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1622.67   (req: < 5)

Gene RIFs: 235   (req: <= 3)

Antibodies: 714   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1622.67   (req: >= 5)

Gene RIFs: 235   (req: > 3)

Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (8)

Explore Active Ligands

1 – 8 of 8

CHEMBL2315288

TXNTchem

IC50: 6.27

CHEMBL2315299

TXNTchem

IC50: 6.29

CHEMBL2315290

TXNTchem

IC50: 6.35

CHEMBL2315306

TXNTchem

IC50: 6.47

CHEMBL2315292

TXNTchem

IC50: 6.54

CHEMBL2315294

TXNTchem

IC50: 6.62

CHEMBL2315297

TXNTchem

IC50: 6.77

CHEMBL2315295

TXNTchem

IC50: 7.05

Protein Data Bank (39)

1 – 5 of 39

PDB Structure Id	Ligand	Method	Resolution (Å)	M.W. (kDa)	Pub Year	Title

PDB Structure Id	M.W.	Resolution	Pub Year

Pathways (37)

Reactome (22)

KEGG (2)

PathwayCommons (6)

WikiPathways (7)

Cellular Senescence (R-HSA-2559583)

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Reactome	FOXO-mediated transcription	68 targets	R-HSA-9614085

Name	Explore in Pharos	Explore in Source
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
FOXO-mediated transcription	68 targets	R-HSA-9614085

Gene Ontology Terms (21)

Functions (3)

Components (3)

Processes (15)

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10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
peptide disulfide oxidoreductase activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein disulfide oxidoreductase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (366)

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1 – 10 of 366

• See Interactions on String-DB

CHCHD4

Tbio

Novelty: 0.01246396

p_int: 0.99538692

p_ni: 0.00461308

Score: 0.486

Data Source: BioPlex,STRINGDB

TXNIP

Tbio

Novelty: 0.00279977

p_int: 0.849381742

p_ni: 0.150618258

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

TXNRD1

Tclin

Family: Enzyme

Novelty: 0.00387669

Score: 0.999

Data Source: Reactome,STRINGDB

PRDX1

Tbio

Novelty: 0.00234504

Score: 0.994

Data Source: Reactome,STRINGDB

MAP3K5

Tchem

Family: Kinase

Novelty: 0.00192027

Score: 0.994

Data Source: Reactome,STRINGDB

SOD1

Tbio

Family: Enzyme

Novelty: 0.00044941

Score: 0.993

Data Source: STRINGDB

PRDX2

Tbio

Novelty: 0.00236489

Score: 0.99

Data Source: Reactome,STRINGDB

MSRA

Tbio

Family: Enzyme

Novelty: 0.00941816

Score: 0.986

Data Source: Reactome,STRINGDB

GSR

Tclin

Family: Enzyme

Novelty: 0.00057594

Score: 0.984

Data Source: STRINGDB

TP53

Tchem

Family: TF

Novelty: 0.00002203

Score: 0.982

Data Source: STRINGDB

Publication Statistics

PubMed Score  1622.67

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PubTator Score  1990.2

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Amino Acid Sequence

Residue Counts

Protein Sequence

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3D-structure
Acetylation
Activator
Alternative splicing
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Cytoplasm
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Disulfide bond
Electron transport
Nucleus

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
mortality/aging