Tchem TXN Thioredoxin

Protein Classes

DTO Classes

Thioredoxin, Mitochondrial / Thioredoxin-dependent Peroxide Reductase, Mitochondrial / Thioredoxin Domain-containing Protein 12 / Thioredoxin Reductase 2, Mitochondrial / Thioredoxin Reductase 3 / Thioredoxin Reductase 1, Cytoplasmic / Thioredoxin Domain-containing Protein 9 / Thioredoxin Domain-containing Protein 17

Protein Summary

Description

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P10599
• B1ALW1
• O60744
• Q53X69
• Q96KI3
• Q9UDG5
• Trx

Gene Name

• TXN

Ensembl ID

• ENST00000374515
• ENSP00000363639
• ENSG00000136810
• ENST00000374517
• ENSP00000363641

Symbol

• TRDX
• TRX
• TRX1
• TRX
• TRDX
• TRX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
biological process	0.98
hub protein	0.98
transcription factor perturbation	0.98

Related Tools

Target Illumination GWAS Analytics (TIGA)

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GENEVA

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GlyGen

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ARCHS4

ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.

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IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1694.89   (req: < 5)

Gene RIFs: 235   (req: <= 3)

Antibodies: 714   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1694.89   (req: >= 5)

Gene RIFs: 235   (req: > 3)

Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0

Active Ligands (8)

Explore Active Ligands

1 – 8 of 8

CHEMBL2315288

TXNTchem

IC50 : 6.27

CHEMBL2315299

TXNTchem

IC50 : 6.29

CHEMBL2315290

TXNTchem

IC50 : 6.35

CHEMBL2315306

TXNTchem

IC50 : 6.47

CHEMBL2315292

TXNTchem

IC50 : 6.54

CHEMBL2315294

TXNTchem

IC50 : 6.62

CHEMBL2315297

TXNTchem

IC50 : 6.77

CHEMBL2315295

TXNTchem

IC50 : 7.05

GWAS Traits (3)

• Explore on Target Illumination GWAS Analytics (TIGA)

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1 – 3 of 3

GWAS Trait	EFO ID	Study Count	SNP Count	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6	1	6		57.2
mean corpuscular hemoglobin concentration	EFO_0004528	1	1	1		54.8
mean reticulocyte volume	EFO_0010701	1	1	1		19.4

• Explore on Target Illumination GWAS Analytics (TIGA)

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GWAS Trait	EFO ID	Beta Count	Odds Ratio	Evidence (Mean Rank Score)	Provenance
sex hormone-binding globulin measurement	EFO_0004696	6		57.2
mean corpuscular hemoglobin concentration	EFO_0004528	1		54.8
mean reticulocyte volume	EFO_0010701	1		19.4

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Orthologs (14)

1 – 5 of 14

Species	Name	Source ID	Gene ID	OMA	EggNOG	Inparanoid
Chimp	thioredoxin	VGNC:4894	740248
Macaque	thioredoxin		712587
Mouse	thioredoxin 1	MGI:98874	22166
Rat	thioredoxin 1	RGD:621157	116484
Horse	thioredoxin		100033827

Species	Name	OMA	EggNOG	Inparanoid
Chimp	thioredoxin
Macaque	thioredoxin
Mouse	thioredoxin 1
Rat	thioredoxin 1
Horse	thioredoxin

Protein Structure (39 Structures, 1 AlphaFold Model)

Representation

  axes   backbone   ball+stick   cartoon   rocket   rope   spacefill

Color Scheme

  target   atomindex   bfactor   chainname   electrostatic   element   hydrophobicity   resname   sstruc

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10599-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 5 of 39

PDB Structure Id	Ligand	Method	Resolution (Å)	Residues	Fraction of Total Protein	Pub Year	Title

PDB Structure Id	Fraction of Total Protein	Resolution	Pub Year

Pathways (37)

Reactome (22)

KEGG (2)

PathwayCommons (6)

WikiPathways (7)

Cellular Senescence (R-HSA-2559583)

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Find Similar Targets

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Data Source	Name	Explore in Pharos	Explore in Source
Reactome	Cellular Senescence	164 targets	R-HSA-2559583
Reactome	Cellular responses to external stimuli	487 targets	R-HSA-8953897
Reactome	Cellular responses to stress	392 targets	R-HSA-2262752
Reactome	Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
Reactome	FOXO-mediated transcription	68 targets	R-HSA-9614085

Name	Explore in Pharos	Explore in Source
Cellular Senescence	164 targets	R-HSA-2559583
Cellular responses to external stimuli	487 targets	R-HSA-8953897
Cellular responses to stress	392 targets	R-HSA-2262752
Detoxification of Reactive Oxygen Species	37 targets	R-HSA-3299685
FOXO-mediated transcription	68 targets	R-HSA-9614085

Gene Ontology Terms (21)

Functions (3)

Components (3)

Processes (15)

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Items per page:

10

1 – 3 of 3

GO Term	Evidence	Assigned by
RNA binding	Inferred from High Throughput Direct Assay (HDA)	UniProtKB
peptide disulfide oxidoreductase activity	Inferred from Electronic Annotation (IEA)	Ensembl
protein disulfide oxidoreductase activity	Inferred from Electronic Annotation (IEA)	InterPro

Protein-Protein Interactions (366)

Explore Interacting Targets

1 – 10 of 366

• See Interactions on String-DB

CHCHD4

Tbio

Novelty: 0.01204944

p_int: 0.99538692

p_ni: 0.00461308

Score: 0.486

Data Source: BioPlex,STRINGDB

TXNIP

Tbio

Novelty: 0.00216952

p_int: 0.849381742

p_ni: 0.150618258

Score: 0.999

Data Source: BioPlex,Reactome,STRINGDB

TXNRD1

Tclin

Family: Enzyme

Novelty: 0.00299018

Score: 0.999

Data Source: Reactome,STRINGDB

PRDX1

Tbio

Novelty: 0.00207935

Score: 0.994

Data Source: Reactome,STRINGDB

MAP3K5

Tchem

Family: Kinase

Novelty: 0.00144614

Score: 0.994

Data Source: Reactome,STRINGDB

SOD1

Tbio

Family: Enzyme

Novelty: 0.00039653

Score: 0.993

Data Source: STRINGDB

PRDX2

Tbio

Novelty: 0.00189751

Score: 0.99

Data Source: Reactome,STRINGDB

MSRA

Tbio

Family: Enzyme

Novelty: 0.00595154

Score: 0.986

Data Source: Reactome,STRINGDB

GSR

Tclin

Family: Enzyme

Novelty: 0.00040107

Score: 0.984

Data Source: STRINGDB

TP53

Tchem

Family: TF

Novelty: 0.00001907

Score: 0.982

Data Source: STRINGDB

Publication Statistics

PubMed Score  1694.89

PubMed score by year

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PubTator Score  1990.2

PubTator score by year

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Amino Acid Sequence

Residue Counts

Protein Sequence

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UniProt Keyword Find Similar Targets

3D-structure
Acetylation
Activator
Alternative splicing
Complete proteome
Cytoplasm
Direct protein sequencing
Disulfide bond
Electron transport
Nucleus

GWAS Trait Find Similar Targets

mean corpuscular hemoglobin concentration
mean reticulocyte volume
sex hormone-binding globulin measurement

MGI Phenotype Find Similar Targets

cellular phenotype
embryo phenotype
mortality/aging