Tchem TXN Thioredoxin

Protein Summary

Description

Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]

Uniprot Accession IDs

• P10599
• B1ALW1
• O60744
• Q53X69
• Q96KI3
• Q9UDG5
• Trx

Gene Name

• TXN

Ensembl ID

• ENST00000374515
• ENSP00000363639
• ENSG00000136810
• ENST00000374517
• ENSP00000363641

Symbol

• TRDX
• TRX
• TRX1
• TRX
• TRDX
• TRX1

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
disease perturbation	1
interacting protein	1
biological process	0.98
hub protein	0.98
transcription factor perturbation	0.98

Protein Classes

DTO Classes

Thioredoxin, Mitochondrial / Thioredoxin-dependent Peroxide Reductase, Mitochondrial / Thioredoxin Domain-containing Protein 12 / Thioredoxin Reductase 2, Mitochondrial / Thioredoxin Reductase 3 / Thioredoxin Reductase 1, Cytoplasmic / Thioredoxin Domain-containing Protein 9 / Thioredoxin Domain-containing Protein 17

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6031.53   (req: < 5)

Gene RIFs: 235   (req: <= 3)

Antibodies: 714   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6031.53   (req: >= 5)

Gene RIFs: 235   (req: > 3)

Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0