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Tchem
TXN
Thioredoxin

Protein Summary
Description
Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. Plays a role in the reversible S-nitrosylation of cysteine residues in target proteins, and thereby contributes to the response to intracellular nitric oxide. Nitrosylates the active site Cys of CASP3 in response to nitric oxide (NO), and thereby inhibits caspase-3 activity. Induces the FOS/JUN AP-1 DNA-binding activity in ionizing radiation (IR) cells through its oxidation/reduction status and stimulates AP-1 transcriptional activity. ADF augments the expression of the interleukin-2 receptor TAC (IL2R/P55). The protein encoded by this gene acts as a homodimer and is involved in many redox reactions. The encoded protein is active in the reversible S-nitrosylation of cysteines in certain proteins, which is part of the response to intracellular nitric oxide. This protein is found in the cytoplasm. Two transcript variants ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000374515
  • ENSP00000363639
  • ENSG00000136810
  • ENST00000374517
  • ENSP00000363641

Symbol
  • TRDX
  • TRX
  • TRX1
  • TRX
  • TRDX
  • TRX1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
disease perturbation
1
interacting protein
1
biological process
0.98
hub protein
0.98
transcription factor perturbation
0.98


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1694.89   (req: < 5)
Gene RIFs: 235   (req: <= 3)
Antibodies: 714   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1694.89   (req: >= 5)
Gene RIFs: 235   (req: > 3)
Antibodies: 714   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 18
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 8
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (3)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
1
6
57.2
mean corpuscular hemoglobin concentration
1
1
1
54.8
mean reticulocyte volume
1
1
1
19.4
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
sex hormone-binding globulin measurement
6
57.2
mean corpuscular hemoglobin concentration
1
54.8
mean reticulocyte volume
1
19.4
Orthologs (14)
1 – 5 of 14
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
thioredoxin
VGNC:4894
740248
Macaque
thioredoxin
712587
Mouse
MGI:98874
22166
Rat
RGD:621157
116484
Horse
thioredoxin
100033827
Species
Name
OMA
EggNOG
Inparanoid
Chimp
thioredoxin
Macaque
thioredoxin
Mouse
Rat
Horse
thioredoxin
Protein Data Bank (39)
1 – 5 of 39
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (37)
Cellular Senescence (R-HSA-2559583)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 22
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Reactome
Cellular responses to stress
Reactome
Detoxification of Reactive Oxygen Species
Reactome
FOXO-mediated transcription
Name
Explore in Pharos
Explore in Source
Cellular Senescence
Cellular responses to external stimuli
Cellular responses to stress
Detoxification of Reactive Oxygen Species
FOXO-mediated transcription
Protein-Protein Interactions (366)
1 – 10 of 366
CHCHD4
Tbio
Novelty: 0.01204944
p_int: 0.99538692
p_ni: 0.00461308
Score: 0.486
Data Source: BioPlex,STRINGDB
TXNIP
Tbio
Novelty: 0.00216952
p_int: 0.849381742
p_ni: 0.150618258
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
TXNRD1
Tclin
Family: Enzyme
Novelty: 0.00299018
Score: 0.999
Data Source: Reactome,STRINGDB
PRDX1
Tbio
Novelty: 0.00207935
Score: 0.994
Data Source: Reactome,STRINGDB
MAP3K5
Tchem
Family: Kinase
Novelty: 0.00144614
Score: 0.994
Data Source: Reactome,STRINGDB
SOD1
Tbio
Family: Enzyme
Novelty: 0.00039653
Score: 0.993
Data Source: STRINGDB
PRDX2
Tbio
Novelty: 0.00189751
Score: 0.99
Data Source: Reactome,STRINGDB
MSRA
Tbio
Family: Enzyme
Novelty: 0.00595154
Score: 0.986
Data Source: Reactome,STRINGDB
GSR
Tclin
Family: Enzyme
Novelty: 0.00040107
Score: 0.984
Data Source: STRINGDB
TP53
Tchem
Family: TF
Novelty: 0.00001907
Score: 0.982
Data Source: STRINGDB
Publication Statistics
PubMed Score  1694.89

PubMed score by year
PubTator Score  1990.2

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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