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Tbio
NR2F1
COUP transcription factor 1

Protein Summary
Description
Coup (chicken ovalbumin upstream promoter) transcription factor binds to the ovalbumin promoter and, in conjunction with another protein (S300-II) stimulates initiation of transcription. Binds to both direct repeats and palindromes of the 5'-AGGTCA-3' motif. Represses transcriptional activity of LHCG. The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000327111
  • ENSP00000325819
  • ENSG00000175745
  • ENST00000644230
  • ENSP00000495420

Symbol
  • EAR3
  • ERBAL3
  • TFCOUP1
  • EAR3
  • BBOAS
  • EAR-3
  • SVP44
  • BBSOAS
  • ERBAL3
  • COUPTF1
  • TFCOUP1
  • COUP-TFI
  • TCFCOUP1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
PubMedID
0.98
molecular function
0.94
gene perturbation
0.86
protein domain
0.85
transcription factor binding site profile
0.85


Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.75   (req: < 5)
Gene RIFs: 26   (req: <= 3)
Antibodies: 254   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 183.75   (req: >= 5)
Gene RIFs: 26   (req: > 3)
Antibodies: 254   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 15
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (10)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
4
4
5
92.4
self reported educational attainment
1
1
1
71.9
soluble triggering receptor expressed on myeloid cells 2 measurement
1
1
0
15744.7
53.3
diet measurement
2
2
2
50.5
cognitive function measurement
1
1
1
40.7
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
mathematical ability
5
92.4
self reported educational attainment
1
71.9
soluble triggering receptor expressed on myeloid cells 2 measurement
0
15744.7
53.3
diet measurement
2
50.5
cognitive function measurement
1
40.7
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group F member 1
VGNC:4103
461753
Macaque
nuclear receptor subfamily 2 group F member 1
700777
Mouse
MGI:1352451
13865
Rat
RGD:621682
81808
Cow
nuclear receptor subfamily 2 group F member 1
VGNC:32240
327684
Species
Name
OMA
EggNOG
Inparanoid
Chimp
nuclear receptor subfamily 2 group F member 1
Macaque
nuclear receptor subfamily 2 group F member 1
Mouse
Rat
Cow
nuclear receptor subfamily 2 group F member 1
Protein Structure (1 Structure, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10589-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 1 of 1
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (27)
Gene expression (Transcription) (R-HSA-74160)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Gene expression (Transcription)
Reactome
Generic Transcription Pathway
Reactome
Nuclear Receptor transcription pathway
Reactome
RNA Polymerase II Transcription
Name
Explore in Pharos
Explore in Source
Gene expression (Transcription)
Generic Transcription Pathway
Nuclear Receptor transcription pathway
RNA Polymerase II Transcription
Gene Ontology Terms (18)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
NTNU_SB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Sequence Model (ISM)
NTNU_SB
Traceable Author Statement (TAS)
ProtInc
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
InterPro
Inferred from Electronic Annotation (IEA)
InterPro
Protein-Protein Interactions (106)
1 – 10 of 106
CD70
Tbio
Novelty:  0.00420393
p_int:  0.967681698
p_ni:  0.032318302
Score:  0.177
Data Source:  BioPlex,STRINGDB
MPPED1
Tdark
Family:  Enzyme
Novelty:  0.58103321
p_int:  0.957949316
p_ni:  0.042050684
Score:  0.239
Data Source:  BioPlex,STRINGDB
MICB
Tbio
Novelty:  0.00364639
p_int:  0.833957347
p_ni:  0.166042649
p_wrong:  3e-9
Data Source:  BioPlex
RERE
Tbio
Family:  TF
Novelty:  0.03065098
Score:  0.95
Data Source:  STRINGDB
RXRA
Tclin
Family:  NR
Novelty:  0.00244343
Score:  0.948
Data Source:  STRINGDB
MYC
Tchem
Family:  TF
Novelty:  0.00005734
Score:  0.926
Data Source:  STRINGDB
MED1
Tbio
Family:  Enzyme
Novelty:  0.00852082
Score:  0.919
Data Source:  STRINGDB
FAT1
Tbio
Novelty:  0.00340342
Score:  0.912
Data Source:  STRINGDB
TNF
Tclin
Novelty:  0.00001457
Score:  0.909
Data Source:  STRINGDB
PPARA
Tclin
Family:  NR
Novelty:  0.00017403
Score:  0.908
Data Source:  STRINGDB
Publication Statistics
PubMed Score  183.75

PubMed score by year
PubTator Score  125.73

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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