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Tchem
PTPRF
Receptor-type tyrosine-protein phosphatase F

Protein Summary
Description
Possible cell adhesion receptor. It possesses an intrinsic protein tyrosine phosphatase activity (PTPase) and dephosphorylates EPHA2 regulating its activity. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains three Ig-like domains, and nine non-Ig like domains similar to that of neural-cell adhesion molecule. This PTP was shown to function in the regulation of epithelial cell-cell contacts at adherents junctions, as well as in the control of beta-cat ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000359947
  • ENSP00000353030
  • ENSG00000142949
  • ENST00000438120
  • ENSP00000398822

Symbol
  • LAR
  • LAR
  • BNAH2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
transcription factor perturbation
0.99
kinase perturbation
0.93
molecular function
0.84
disease perturbation
0.83


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.04   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 265   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 85.04   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 265   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 14
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 10
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Active Ligands (10)
1 – 10 of 10
CHEMBL200117
Rendered image for CHEMBL200117
CHEMBL324232
Rendered image for CHEMBL324232
oxalylaminobenzoic acid
Rendered image for oxalylaminobenzoic acid
CHEMBL556636
Rendered image for CHEMBL556636
CHEMBL564699
Rendered image for CHEMBL564699
CHEMBL549372
Rendered image for CHEMBL549372
CHEMBL556076
Rendered image for CHEMBL556076
CHEMBL550662
Rendered image for CHEMBL550662
CHEMBL570779
Rendered image for CHEMBL570779
illudalic acid
Rendered image for illudalic acid
Protein-Protein Interactions (90)
1 – 10 of 90
SCN2B
Tbio
Family:  IC
Novelty:  0.03773629
p_int:  0.999647099
p_ni:  0.000352901
p_wrong:  1e-9
Data Source:  BioPlex
WFDC2
Tbio
Novelty:  0.0136923
p_int:  0.997424267
p_ni:  0.002575733
Score:  0.198
Data Source:  BioPlex,STRINGDB
IL13RA2
Tbio
Novelty:  0.03465642
p_int:  0.994739838
p_ni:  0.005260162
Data Source:  BioPlex
CLU
Tbio
Novelty:  0.00054776
p_int:  0.966335835
p_ni:  0.033664165
Score:  0.19
Data Source:  BioPlex,STRINGDB
LRRIQ1
Tdark
Novelty:  1.8251367
p_int:  0.924973474
p_ni:  0.075026526
Score:  0.175
Data Source:  BioPlex,STRINGDB
TMEM30B
Tbio
Novelty:  0.26735006
p_int:  0.896030625
p_ni:  0.103969375
Score:  0.293
Data Source:  BioPlex,STRINGDB
PCDHGB1
Tdark
Novelty:  0.60440805
p_int:  0.893422548
p_ni:  0.106577452
Score:  0.251
Data Source:  BioPlex,STRINGDB
ATP6V0E1
Tbio
Family:  Enzyme
Novelty:  0.076209
p_int:  0.869414458
p_ni:  0.130585542
Score:  0.173
Data Source:  BioPlex,STRINGDB
MANSC1
Tdark
Novelty:  0.91681036
p_int:  0.846345999
p_ni:  0.153654001
Data Source:  BioPlex
PCDHB16
Tdark
Novelty:  0.67206411
p_int:  0.844331525
p_ni:  0.155668475
Score:  0.221
Data Source:  BioPlex,STRINGDB
Pathways (32)
Neuronal System (R-HSA-112316)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 4 of 4
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Neuronal System
Reactome
Protein-protein interactions at synapses
Reactome
Receptor-type tyrosine-protein phosphatases
Reactome
Synaptic adhesion-like molecules
Name
Explore in Pharos
Explore in Source
Neuronal System
Protein-protein interactions at synapses
Receptor-type tyrosine-protein phosphatases
Synaptic adhesion-like molecules
Gene Ontology Terms (19)
Items per page:
10
1 – 6 of 6
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Physical Interaction (IPI)
SynGO-UCL
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
Inferred from Electronic Annotation (IEA)
Ensembl
GWAS Traits (28)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
6
7
7
6.6
97
mathematical ability
4
3
5
91.3
smoking initiation
3
3
3
89.7
smoking status measurement
2
1
2
82.6
7
4
2
1.1
81.5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
self reported educational attainment
7
6.6
97
mathematical ability
5
91.3
smoking initiation
3
89.7
smoking status measurement
2
82.6
2
1.1
81.5
Find similar targets by:
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type F
VGNC:9889
456828
Macaque
protein tyrosine phosphatase, receptor type F
701160
Mouse
MGI:102695
19268
Rat
RGD:3453
360406
Dog
protein tyrosine phosphatase, receptor type F
VGNC:45187
475389
Species
Name
OMA
EggNOG
Inparanoid
Chimp
protein tyrosine phosphatase, receptor type F
Macaque
protein tyrosine phosphatase, receptor type F
Mouse
Rat
Dog
protein tyrosine phosphatase, receptor type F
Publication Statistics
PubMed Score 85.04
PubMed score by year
PubTator Score 198.44
PubTator score by year