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Tbio
SAG
S-arrestin

Protein Summary
Description
Binds to photoactivated, phosphorylated RHO and terminates RHO signaling via G-proteins by competing with G-proteins for the same binding site on RHO (By similarity). May play a role in preventing light-dependent degeneration of retinal photoreceptor cells (PubMed:9565049). Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G-protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. S-arrestin, also known as S-antigen, is a major soluble photoreceptor protein that is involved in desensitization of the photoactivated transduction cascade. It is expressed in the retina and the pineal gland and inhibits coupling of rhodopsin to transducin in vitro. Additionally, S-arrestin is highly antigenic, and is capable of inducing experimental autoimmune uveoretinitis. Mutations in this gene have been associated with Oguchi disease, a rare autosomal r ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000409110
  • ENSP00000386444
  • ENSG00000130561
  • ENST00000631149
  • ENSP00000486571
  • ENSG00000281857

Symbol
  • RP47
  • S-AG
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.92
gene perturbation
0.79
virus perturbation
0.72
interacting protein
0.61
cell line
0.55


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.59   (req: < 5)
Gene RIFs: 18   (req: <= 3)
Antibodies: 242   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 2302.59   (req: >= 5)
Gene RIFs: 18   (req: > 3)
Antibodies: 242   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (5)
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
1
1
71.5
lymphocyte count
1
1
1
71.5
hemoglobin measurement
1
1
1
9.3
1
1
0
1.1
7.7
glomerular filtration rate
1
1
1
3
Items per page:
1 – 5 of 5
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
1
71.5
lymphocyte count
1
71.5
hemoglobin measurement
1
9.3
0
1.1
7.7
glomerular filtration rate
1
3
Orthologs (13)
1 – 5 of 13
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
S-antigen visual arrestin
VGNC:14433
460023
Macaque
S-antigen visual arrestin
714160
Mouse
MGI:98227
20215
Rat
RGD:3619
25539
Dog
S-antigen visual arrestin
VGNC:45846
403906
Species
Name
OMA
EggNOG
Inparanoid
Chimp
S-antigen visual arrestin
Macaque
S-antigen visual arrestin
Mouse
Rat
Dog
S-antigen visual arrestin
Pathways (11)
Activation of the phototransduction cascade (R-HSA-2485179)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 8
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of the phototransduction cascade
Reactome
G alpha (i) signalling events
Reactome
GPCR downstream signalling
Reactome
Inactivation, recovery and regulation of the phototransduction cascade
Reactome
Signal Transduction
Name
Explore in Pharos
Explore in Source
Activation of the phototransduction cascade
G alpha (i) signalling events
GPCR downstream signalling
Inactivation, recovery and regulation of the phototransduction cascade
Signal Transduction
Gene Ontology Terms (10)
Items per page:
10
1 – 3 of 3
GO Term
Evidence
Assigned by
Traceable Author Statement (TAS)
ProtInc
Inferred from Electronic Annotation (IEA)
Ensembl
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (205)
1 – 10 of 205
ARRB1
Tbio
Novelty: 0.00262758
p_int: 0.999999994
p_wrong: 6e-9
Score: 0.427
Data Source: BioPlex,STRINGDB
RHO
Tbio
Family: GPCR
Novelty: 0.00012925
Score: 0.999
Data Source: Reactome,STRINGDB
GRK1
Tchem
Family: Kinase
Novelty: 0.00598725
Score: 0.988
Data Source: STRINGDB
RCVRN
Tbio
Novelty: 0.00266222
Score: 0.97
Data Source: STRINGDB
GNAT1
Tbio
Novelty: 0.03042002
Score: 0.948
Data Source: STRINGDB
GNGT1
Tbio
Novelty: 0.05291961
Score: 0.924
Data Source: STRINGDB
GNB1
Tbio
Novelty: 0.02477955
Score: 0.922
Data Source: STRINGDB
GRK7
Tchem
Family: Kinase
Novelty: 0.01119521
Score: 0.885
Data Source: STRINGDB
GRK2
Tchem
Family: Kinase
Novelty: 0.00200696
Score: 0.857
Data Source: STRINGDB
RBP3
Tbio
Family: Enzyme
Novelty: 0.00204835
Score: 0.804
Data Source: STRINGDB
Publication Statistics
PubMed Score  2302.59

PubMed score by year
PubTator Score  448.56

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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