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Tbio
DLAT
Dihydrolipoyllysine-residue acetyltransferase component of pyruvate dehydrogenase complex, mitochondrial

Protein Summary
Description
The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. This gene encodes component E2 of the multi-enzyme pyruvate dehydrogenase complex (PDC). PDC resides in the inner mitochondrial membrane and catalyzes the conversion of pyruvate to acetyl coenzyme A. The protein product of this gene, dihydrolipoamide acetyltransferase, accepts acetyl groups formed by the oxidative decarboxylation of pyruvate and transfers them to coenzyme A. Dihydrolipoamide acetyltransferase is the antigen for antimitochondrial antibodies. These autoantibodies are present in nearly 95% of patients with the autoimmune liver disease primary biliary cirrhosis (PBC). In PBC, activated T lymphocytes attack and destroy epithelial cells in the bile duct where this protein is abnormally distributed and overexpressed. PBC enventually leads to cirrhosis and liver failure. Mutations in this gene are also a c ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000280346
  • ENSP00000280346
  • ENSG00000150768

Symbol
  • DLTA
  • E2
  • DLTA
  • PDCE2
  • PDC-E2
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein complex
1
kinase perturbation
0.97
transcription factor perturbation
0.94
protein domain
0.92
virus perturbation
0.9


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.63   (req: < 5)
Gene RIFs: 15   (req: <= 3)
Antibodies: 288   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 263.63   (req: >= 5)
Gene RIFs: 15   (req: > 3)
Antibodies: 288   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 6
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Data Bank (11)
1 – 5 of 11
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (47)
Cell redox homeostasis (R-HSA-1222541)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 14
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cell redox homeostasis
Reactome
Disease
Reactome
Glyoxylate metabolism and glycine degradation
Reactome
Infectious disease
Reactome
Latent infection - Other responses of Mtb to phagocytosis
Name
Explore in Pharos
Explore in Source
Cell redox homeostasis
Disease
Glyoxylate metabolism and glycine degradation
Infectious disease
Latent infection - Other responses of Mtb to phagocytosis
Protein-Protein Interactions (167)
1 – 10 of 167
PDK3
Tchem
Family: Kinase
Novelty: 0.08817749
p_int: 0.997679711
p_ni: 0.002320289
Score: 0.998
Data Source: BioPlex,Reactome,STRINGDB
PDHB
Tbio
Family: Enzyme
Novelty: 0.01625694
p_int: 0.996133986
p_ni: 0.003866014
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
DLD
Tbio
Family: Enzyme
Novelty: 0.00268083
p_int: 0.9547131
p_ni: 0.0452869
Score: 0.999
Data Source: BioPlex,Reactome,STRINGDB
FOXD4
Tbio
Family: TF
Novelty: 0.15916764
p_int: 0.898755786
p_ni: 0.101244214
Score: 0.683
Data Source: BioPlex,STRINGDB
MIF
Tchem
Novelty: 0.00055002
p_int: 0.783185858
p_ni: 0.216814142
Data Source: BioPlex
PDHA1
Tbio
Family: Enzyme
Novelty: 0.00498626
Score: 0.999
Data Source: Reactome,STRINGDB
OGDH
Tbio
Family: Enzyme
Novelty: 0.01059143
Score: 0.998
Data Source: STRINGDB
CS
Tbio
Family: Enzyme
Novelty: 0.00182322
Score: 0.997
Data Source: STRINGDB
PDHA2
Tbio
Family: Enzyme
Novelty: 0.06763029
Score: 0.997
Data Source: Reactome,STRINGDB
DLST
Tbio
Family: Enzyme
Novelty: 0.01645513
Score: 0.993
Data Source: STRINGDB
Publication Statistics
PubMed Score  263.63

PubMed score by year
PubTator Score  203.95

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer