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Tclin
BCL2
Apoptosis regulator Bcl-2

Protein Summary
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333681
  • ENSP00000329623
  • ENSG00000171791
  • ENST00000398117
  • ENSP00000381185
  • ENST00000589955
  • ENSP00000466417

Symbol
  • Bcl-2
  • PPP1R50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
co-expressed gene
0.99
hub protein
0.99


Protein Classes
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28130.89   (req: < 5)
Gene RIFs: 1809   (req: <= 3)
Antibodies: 3436   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 28130.89   (req: >= 5)
Gene RIFs: 1809   (req: > 3)
Antibodies: 3436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 122
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1516
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 3