Protein Summary
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
- ENST00000333681
- ENSP00000329623
- ENSG00000171791
- ENST00000398117
- ENSP00000381185
- ENST00000589955
- ENSP00000466417
- Bcl-2
- PPP1R50
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
biological process | 1 | ||
biological term | 1 | ||
chemical | 1 | ||
co-expressed gene | 0.99 | ||
hub protein | 0.99 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28130.89 (req: < 5)
Gene RIFs: 1535 (req: <= 3)
Antibodies: 3436 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 28130.89 (req: >= 5)
Gene RIFs: 1535 (req: > 3)
Antibodies: 3436 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 122
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 1516
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drugs: 3
Expression Data (0 Tissues)
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools (4)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (3)
Active Ligands (1516)
Protein-Protein Interactions (200)
ABCB1
Family: Transporter
Novelty: 0.00018144
p_int: 0.999999915
p_ni: 6.7e-8
p_wrong: 1.8e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
Q96PG8
Novelty: 0.00773944
p_int: 0.99999849
p_ni: 0.000001509
p_wrong: 1e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
BAD
Novelty: 0.01273317
p_int: 0.999995706
p_ni: 0.000004294
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
MTHFR
Family: Enzyme
Novelty: 0.00018162
p_int: 0.999881692
p_ni: 0.000118308
p_wrong: 1e-9
Data Source: BioPlex
BAX
Novelty: 0.00150653
p_int: 0.999881038
p_ni: 0.000118962
Score: 0.967
Data Source: BioPlex,STRINGDB
BCL2L11
Novelty: 0.00055914
p_int: 0.997509561
p_ni: 0.0006702
p_wrong: 0.001820241
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BCL2L1
Novelty: 0.00018414
p_int: 0.875098823
p_ni: 8.3e-8
p_wrong: 0.124901094
Score: 0.991
Data Source: BioPlex,STRINGDB
Nearest Tclin Targets
Pathways (115)
Reactome (20)
KEGG (38)
PathwayCommons (21)
WikiPathways (36)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Activation of BAD and translocation to mitochondria | ||||
Reactome | Activation of BH3-only proteins | ||||
Reactome | Apoptosis | ||||
Reactome | BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Reactome | Cytokine Signaling in Immune system | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Activation of BAD and translocation to mitochondria | ||||
Activation of BH3-only proteins | ||||
Apoptosis | ||||
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members | ||||
Cytokine Signaling in Immune system | ||||
Viral Interactions (0)
Gene Ontology Terms (135)
Functions (11)
Components (13)
Processes (111)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | BHF-UCL | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | MGI | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | IntAct | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Physical Interaction (IPI) | UniProtKB | |||
Inferred from Electronic Annotation (IEA) | Ensembl | |||
Disease Associations (null)
GWAS Traits (65)
Items per page:
1 – 5 of 65
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 4 | 3 | 9 | 93.4 | |||||
sex hormone-binding globulin measurement | 8 | 3 | 12 | 7 | 92.3 | ||||
mosaic loss of chromosome Y measurement | 1 | 1 | 1 | 90.3 | |||||
eosinophil count | 5 | 4 | 7 | 90.1 | |||||
type 2 diabetes mellitus | 7 | 1 | 4 | 1.1 | 89.8 | ||||
Items per page:
1 – 5 of 65
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
BMI-adjusted waist-hip ratio | 9 | 93.4 | |||||
sex hormone-binding globulin measurement | 12 | 7 | 92.3 | ||||
mosaic loss of chromosome Y measurement | 1 | 90.3 | |||||
eosinophil count | 7 | 90.1 | |||||
type 2 diabetes mellitus | 4 | 1.1 | 89.8 | ||||
Find similar targets by:
IDG Resources
Orthologs (9)
1 – 5 of 9
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Mouse | MGI:88138 | 12043 | ||||||
Rat | RGD:2199 | 24224 | ||||||
Dog | BCL2, apoptosis regulator | VGNC:54274 | 403416 | |||||
Horse | BCL2, apoptosis regulator | VGNC:15790 | 100050934 | |||||
Cow | BCL2, apoptosis regulator | VGNC:26445 | 281020 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Mouse | ||||||
Rat | ||||||
Dog | BCL2, apoptosis regulator | |||||
Horse | BCL2, apoptosis regulator | |||||
Cow | BCL2, apoptosis regulator | |||||
Publication Statistics
PubMed Score 28130.89
PubMed score by year
PubTator Score 14950.24
PubTator score by year
Related Publications
Text Mined References (1740)
GeneRif Annotations (1535)
Items per page:
0 of 0
PMID | Year | Title |
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