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Tclin
BCL2
Apoptosis regulator Bcl-2

Protein Classes
PANTHER Classes Protein / Signaling Molecule / Apoptosis Regulator Bcl-2
Protein Summary
Description
Suppresses apoptosis in a variety of cell systems including factor-dependent lymphohematopoietic and neural cells. Regulates cell death by controlling the mitochondrial membrane permeability. Appears to function in a feedback loop system with caspases. Inhibits caspase activity either by preventing the release of cytochrome c from the mitochondria and/or by binding to the apoptosis-activating factor (APAF-1). May attenuate inflammation by impairing NLRP1-inflammasome activation, hence CASP1 activation and IL1B release (PubMed:17418785). This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000333681
  • ENSP00000329623
  • ENSG00000171791
  • ENST00000398117
  • ENSP00000381185
  • ENST00000589955
  • ENSP00000466417

Symbol
  • Bcl-2
  • PPP1R50
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
1
biological term
1
chemical
1
co-expressed gene
0.99
hub protein
0.99


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.09   (req: < 5)
View Publications
Gene RIFs: 1535   (req: <= 3)
View Gene RIFs
Antibodies: 3436   (req: <= 50)
View Antibodies
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 147.09   (req: >= 5)
Gene RIFs: 1535   (req: > 3)
Antibodies: 3436   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 122
View GO Terms
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 1279
Explore Active Ligands
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drugs: 2
Explore Approved Drugs
Protein Data Bank (20)
1 – 5 of 20
PDB Structure Id
Ligand
Method
Resolution (Å)
M.W. (kDa)
Pub Year
Title
PDB Structure Id
M.W.
Resolution
Pub Year
Pathways (115)
Activation of BAD and translocation to mitochondria (R-HSA-111447)

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Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Activation of BAD and translocation to mitochondria
15 targets
R-HSA-111447
Reactome
Activation of BH3-only proteins
31 targets
R-HSA-114452
Reactome
Apoptosis
177 targets
R-HSA-109581
Reactome
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
10 targets
R-HSA-111453
Reactome
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Name
Explore in Pharos
Explore in Source
Activation of BAD and translocation to mitochondria
15 targets
R-HSA-111447
Activation of BH3-only proteins
31 targets
R-HSA-114452
Apoptosis
177 targets
R-HSA-109581
BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members
10 targets
R-HSA-111453
Cytokine Signaling in Immune system
922 targets
R-HSA-1280215
Gene Ontology Terms (135)
Items per page:
10
1 – 10 of 11
GO Term
Evidence
Assigned by
channel activity
Inferred from Direct Assay (IDA)
BHF-UCL
channel inhibitor activity
Inferred from Direct Assay (IDA)
BHF-UCL
protease binding
Inferred from Direct Assay (IDA)
UniProtKB
sequence-specific DNA binding
Inferred from Direct Assay (IDA)
MGI
BH3 domain binding
Inferred from Physical Interaction (IPI)
UniProtKB
identical protein binding
Inferred from Physical Interaction (IPI)
IntAct
protein heterodimerization activity
Inferred from Physical Interaction (IPI)
UniProtKB
protein homodimerization activity
Inferred from Physical Interaction (IPI)
UniProtKB
ubiquitin protein ligase binding
Inferred from Physical Interaction (IPI)
UniProtKB
protein phosphatase 2A binding
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (200)
1 – 10 of 200
ABCB1
Tchem
Family: Transporter
Novelty: 0.00022166
p_int: 0.999999915
p_ni: 6.7e-8
p_wrong: 1.8e-8
Score: 0.179
Data Source: BioPlex,STRINGDB
BBC3
Tbio
Novelty: 0.01058903
p_int: 0.99999849
p_ni: 0.000001509
p_wrong: 1e-9
Score: 0.972
Data Source: BioPlex,STRINGDB
BAD
Tchem
Novelty: 0.00705761
p_int: 0.999995706
p_ni: 0.000004294
Score: 0.994
Data Source: BioPlex,Reactome,STRINGDB
MTHFR
Tbio
Family: Enzyme
Novelty: 0.00020963
p_int: 0.999881692
p_ni: 0.000118308
p_wrong: 1e-9
Data Source: BioPlex
BAX
Tchem
Novelty: 0.00204345
p_int: 0.999881038
p_ni: 0.000118962
Score: 0.967
Data Source: BioPlex,STRINGDB
BCL2L11
Tbio
Novelty: 0.00061517
p_int: 0.997509561
p_ni: 0.0006702
p_wrong: 0.001820241
Score: 0.997
Data Source: BioPlex,Reactome,STRINGDB
BCL2L1
Tchem
Novelty: 0.00021916
p_int: 0.875098823
p_ni: 8.3e-8
p_wrong: 0.124901094
Score: 0.991
Data Source: BioPlex,STRINGDB
CASP8
Tchem
Family: Enzyme
Novelty: 0.00026844
Score: 0.996
Data Source: STRINGDB
CASP2
Tchem
Family: Enzyme
Novelty: 0.00224248
Score: 0.995
Data Source: STRINGDB
BID
Tbio
Novelty: 0.01362871
Score: 0.99
Data Source: Reactome,STRINGDB
Publication Statistics
PubMed Score  147.09

PubMed score by year
PubTator Score  14950.24

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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