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Tbio
HIST1H1E
Histone H1.4

Protein Summary
Description
Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber. Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers. Acts also as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity). Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromi ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000304218
  • ENSP00000307705
  • ENSG00000168298

Symbol
  • H1F4
  • H1E
  • H1.4
  • H1F4
  • RMNS
  • H1s-4
  • dJ221C16.5
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
interacting protein
0.99
ligand (protein) perturbation
0.96
drug perturbation
0.87
cellular component
0.68
transcription factor binding site profile
0.67


Related Tools
Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.8   (req: < 5)
Gene RIFs: 12   (req: <= 3)
Antibodies: 376   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 83.8   (req: >= 5)
Gene RIFs: 12   (req: > 3)
Antibodies: 376   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 19
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
GWAS Traits (2)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
1
1
29.3
intelligence
2
1
1
6.6
5.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
body height
1
29.3
intelligence
1
6.6
5.9
Orthologs (5)
1 – 5 of 5
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member e
VGNC:14369
471881
Mouse
MGI:1931527
50709
Rat
RGD:2776
201097
Dog
histone H1.4
488269
Cow
histone cluster 1, H1e
617854
Species
Name
OMA
EggNOG
Inparanoid
Chimp
histone cluster 1 H1 family member e
Mouse
Rat
Dog
histone H1.4
Cow
histone cluster 1, H1e
Protein Structure (3 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10412-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 3 of 3
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (66)
Apoptosis (R-HSA-109581)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 9
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Apoptosis
Reactome
Apoptosis induced DNA fragmentation
Reactome
Apoptotic execution phase
Reactome
Cellular Senescence
Reactome
Cellular responses to external stimuli
Name
Explore in Pharos
Explore in Source
Apoptosis
Apoptosis induced DNA fragmentation
Apoptotic execution phase
Cellular Senescence
Cellular responses to external stimuli
Gene Ontology Terms (22)
Items per page:
10
1 – 10 of 10
GO Term
Evidence
Assigned by
Inferred from Mutant Phenotype (IMP)
UniProtKB
Inferred from High Throughput Direct Assay (HDA)
UniProtKB
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Biological aspect of Ancestor (IBA)
GO_Central
Inferred from Electronic Annotation (IEA)
Ensembl
Protein-Protein Interactions (179)
1 – 10 of 179
YBX2
Tbio
Family: TF
Novelty: 0.01540247
p_int: 0.999994359
p_ni: 0.00000564
p_wrong: 1e-9
Score: 0.529
Data Source: BioPlex,STRINGDB
HIST1H1T
Tdark
Novelty: 0.01039464
p_int: 0.999991643
p_ni: 0.000008357
Score: 0.324
Data Source: BioPlex,STRINGDB
LEO1
Tbio
Family: Enzyme
Novelty: 0.00851903
p_int: 0.999233457
p_ni: 0.000757476
p_wrong: 0.000009067
Score: 0.266
Data Source: BioPlex,STRINGDB
ZNF346
Tbio
Novelty: 0.00204191
p_int: 0.996632489
p_ni: 0.003367483
p_wrong: 2.8e-8
Data Source: BioPlex
UBTF
Tbio
Family: TF
Novelty: 0.00421069
p_int: 0.996478003
p_ni: 0.003521997
Score: 0.304
Data Source: BioPlex,STRINGDB
CMSS1
Tdark
Novelty: 0.21418543
p_int: 0.996338923
p_ni: 0.003661077
Data Source: BioPlex
RBM19
Tbio
Novelty: 0.15784228
p_int: 0.992766297
p_ni: 0.007233703
Data Source: BioPlex
RPS3
Tbio
Novelty: 0.003106
p_int: 0.991388064
p_ni: 0.008611936
Score: 0.163
Data Source: BioPlex,STRINGDB
CTR9
Tbio
Family: Enzyme
Novelty: 0.04434964
p_int: 0.987217525
p_ni: 0.012782458
p_wrong: 1.7e-8
Score: 0.213
Data Source: BioPlex,STRINGDB
ZNF354A
Tbio
Family: TF
Novelty: 0.04870859
p_int: 0.982791727
p_ni: 0.01720732
p_wrong: 9.53e-7
Data Source: BioPlex
Publication Statistics
PubMed Score  83.80

PubMed score by year
PubTator Score  46.14

PubTator score by year
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer