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Tchem
ARAF
Serine/threonine-protein kinase A-Raf

Protein Summary
Description
Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade. Isoform 2: Serves as a positive regulator of myogenic differentiation by inducing cell cycle arrest, the expression of myogenin and other muscle-specific proteins, and myotube formation. This proto-oncogene belongs to the RAF subfamily of the Ser/Thr protein kinase family, and maybe involved in cell growth and development. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2012]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000377039
  • ENSP00000366238
  • ENSG00000078061
  • ENST00000377045
  • ENSP00000366244

Symbol
  • ARAF1
  • PKS
  • PKS2
  • PKS2
  • A-RAF
  • ARAF1
  • RAFA1
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
protein domain
0.99
kinase perturbation
0.97
interacting protein
0.96
molecular function
0.96
disease perturbation
0.95


Related Tools
ProKinO
The ProKinO is a protein kinase-specific ontology, which provides a controlled vocabulary of terms, their hierarchy, and relationships unifying sequence, structure, function, mutation and pathway information on kinases.
GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.17   (req: < 5)
Gene RIFs: 19   (req: <= 3)
Antibodies: 619   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 207.17   (req: >= 5)
Gene RIFs: 19   (req: > 3)
Antibodies: 619   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 10
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligands: 2
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 1
Approved Drugs (1)
1 – 1 of 1
dabrafenib
chemical structure image
Orthologs (12)
1 – 5 of 12
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
A-Raf proto-oncogene, serine/threonine kinase
100614256
Macaque
A-Raf proto-oncogene, serine/threonine kinase
707169
Mouse
MGI:88065
11836
Rat
RGD:2148
64363
Dog
A-Raf proto-oncogene, serine/threonine kinase
VGNC:38024
491857
Species
Name
OMA
EggNOG
Inparanoid
Chimp
A-Raf proto-oncogene, serine/threonine kinase
Macaque
A-Raf proto-oncogene, serine/threonine kinase
Mouse
Rat
Dog
A-Raf proto-oncogene, serine/threonine kinase
Protein Structure (2 Structures, 1 AlphaFold Model)
RepresentationColor Scheme

Click on a row in the table to change the structure displayed.
More information can be found at RCSB PDB

AF-P10398-F1-model_v1

AlphaFold Structures Developed by DeepMind and EMBL-EBI

1 – 2 of 2
PDB Structure Id
Ligand
Method
Resolution (Å)
Residues
Fraction of Total Protein
Pub Year
Title
PDB Structure Id
Fraction of Total Protein
Resolution
Pub Year
Pathways (118)
Cytokine Signaling in Immune system (R-HSA-1280215)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 20
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Cytokine Signaling in Immune system
Reactome
Disease
Reactome
Diseases of signal transduction
Reactome
FLT3 Signaling
Reactome
Immune System
Name
Explore in Pharos
Explore in Source
Cytokine Signaling in Immune system
Disease
Diseases of signal transduction
FLT3 Signaling
Immune System
Protein-Protein Interactions (175)
1 – 10 of 175
BRAF
Tclin
Family: Kinase
Novelty: 0.00253795
p_int: 0.999791505
p_ni: 0.000208495
Score: 0.952
Data Source: BioPlex,Reactome,STRINGDB
STK36
Tbio
Family: Kinase
Novelty: 0.0963277
p_int: 0.934724605
p_ni: 0.065275395
Data Source: BioPlex
P4HA2
Tbio
Family: Enzyme
Novelty: 0.02097718
p_int: 0.76660927
p_ni: 0.23339073
Score: 0.196
Data Source: BioPlex,STRINGDB
NRAS
Tchem
Family: Enzyme
Novelty: 0.00080922
Score: 0.994
Data Source: Reactome,STRINGDB
HRAS
Tchem
Family: Enzyme
Novelty: 0.00008069
Score: 0.994
Data Source: Reactome,STRINGDB
MAP2K2
Tclin
Family: Kinase
Novelty: 0.00706525
Score: 0.992
Data Source: STRINGDB
KRAS
Tchem
Family: Enzyme
Novelty: 0.00013856
Score: 0.991
Data Source: Reactome,STRINGDB
MAP2K1
Tclin
Family: Kinase
Novelty: 0.0005278
Score: 0.988
Data Source: STRINGDB
RAP1A
Tchem
Family: Enzyme
Novelty: 0.00375413
Score: 0.979
Data Source: STRINGDB
RAP1B
Tbio
Family: Enzyme
Novelty: 0.00627538
Score: 0.977
Data Source: STRINGDB
Publication Statistics
PubMed Score  207.17

PubMed score by year
PubTator Score  111.55

PubTator score by year
Patents
Amino Acid Sequence
Residue Counts
Protein Sequence
ProtVista Viewer
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