Protein Summary
Acrosin is the major protease of mammalian spermatozoa. It is a serine protease of trypsin-like cleavage specificity, it is synthesized in a zymogen form, proacrosin and stored in the acrosome. Acrosin is the major proteinase present in the acrosome of mature spermatozoa. It is a typical serine proteinase with trypsin-like specificity. It is stored in the acrosome in its precursor form, proacrosin. The active enzyme functions in the lysis of the zona pellucida, thus facilitating penetration of the sperm through the innermost glycoprotein layers of the ovum. The mRNA for proacrosin is synthesized only in the postmeiotic stages of spermatogenesis. In humans proacrosin first appears in the haploid spermatids. [provided by RefSeq, Jul 2008]
- ENST00000216139
- ENSP00000216139
- ENSG00000100312
- ENST00000636109
- ENSP00000490828
- ENSG00000283539
- ACRS
Most Knowledge About | Knowledge Value
(0 to 1 scale) | ||
|---|---|---|---|
molecular function | 0.91 | ||
gene perturbation | 0.76 | ||
tissue sample | 0.74 | ||
protein domain | 0.73 | ||
biological process | 0.71 | ||
Protein Classes
IDG Development Level Summary
These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1486.32 (req: < 5)
Gene RIFs: 4 (req: <= 3)
Antibodies: 182 (req: <= 50)
These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:
Pubmed score: 1486.32 (req: >= 5)
Gene RIFs: 4 (req: > 3)
Antibodies: 182 (req: > 50)
- OR - satisfy the following criterion:
Gene Ontology Terms: 16
Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions
Active Ligands: 24
Target has at least one approved drug - AND - satisfies the preceding conditions
Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
Related Tools
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
Active Ligands (24)
Protein-Protein Interactions (58)
Nearest Tclin Targets
Pathways (3)
Reactome (3)
Click on a row in the table to change the structure displayed.
Data Source | Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|---|
Reactome | Acrosome Reaction and Sperm:Oocyte Membrane Binding | ||||
Reactome | Fertilization | ||||
Reactome | Reproduction | ||||
Name | Explore in Pharos | Explore in Source | ||
|---|---|---|---|---|
Acrosome Reaction and Sperm:Oocyte Membrane Binding | ||||
Fertilization | ||||
Reproduction | ||||
Viral Interactions (0)
Gene Ontology Terms (21)
Functions (9)
Components (5)
Processes (7)
GO Term | Evidence | Assigned by | ||
|---|---|---|---|---|
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Direct Assay (IDA) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Inferred from Sequence or structural Similarity (ISS) | UniProtKB | |||
Traceable Author Statement (TAS) | Reactome | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Non-traceable Author Statement (NAS) | UniProtKB | |||
Disease Associations ()
GWAS Traits (10)
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Study Count | SNP Count | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|---|---|
self reported educational attainment | 4 | 4 | 3 | 5.7 | 89.2 | ||||
mean platelet volume | 3 | 2 | 3 | 87.9 | |||||
mathematical ability | 3 | 2 | 3 | 81 | |||||
cognitive function measurement | 1 | 1 | 1 | 53.7 | |||||
intelligence | 4 | 5 | 4 | 5.7 | 52.4 | ||||
Items per page:
1 – 5 of 10
GWAS Trait | EFO ID | Beta Count | Odds Ratio | Evidence (Mean Rank Score) | Provenance | ||
|---|---|---|---|---|---|---|---|
self reported educational attainment | 3 | 5.7 | 89.2 | ||||
mean platelet volume | 3 | 87.9 | |||||
mathematical ability | 3 | 81 | |||||
cognitive function measurement | 1 | 53.7 | |||||
intelligence | 4 | 5.7 | 52.4 | ||||
Find similar targets by:
IDG Resources
Orthologs (10)
1 – 5 of 10
Species | Name | Source ID | Gene ID | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|---|---|
Chimp | acrosin | VGNC:12799 | 458950 | |||||
Macaque | acrosin | 716579 | ||||||
Mouse | MGI:87884 | 11434 | ||||||
Rat | RGD:2024 | 24163 | ||||||
Dog | acrosin | VGNC:37526 | 606765 | |||||
Species | Name | OMA | EggNOG | Inparanoid | ||
|---|---|---|---|---|---|---|
Chimp | acrosin | |||||
Macaque | acrosin | |||||
Mouse | ||||||
Rat | ||||||
Dog | acrosin | |||||
Publication Statistics
PubMed Score 1486.32
PubMed score by year
PubTator Score 1397.80
PubTator score by year
Related Publications
Text Mined References (34)
GeneRif Annotations (4)
Items per page:
0 of 0
PMID | Year | Title |
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