You are using an outdated browser. Please upgrade your browser to improve your experience.

Tbio
HLA-C
HLA class I histocompatibility antigen, Cw-7 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-C belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon one encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domain, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Over one hundred HLA-C alleles h ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000376228
  • ENSP00000365402
  • ENSG00000204525

Symbol
  • HLAC
  • MHC
  • HLAC
  • HLC-C
  • D6S204
  • PSORS1
  • HLA-JY3
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.1   (req: < 5)
Gene RIFs: 304   (req: <= 3)
Antibodies: 213   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 1553.1   (req: >= 5)
Gene RIFs: 304   (req: > 3)
Antibodies: 213   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 8
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (313)
1 – 10 of 313
HLA-B
Tbio
Novelty:  0.00790207
p_int:  0.999999446
p_ni:  5.54e-7
Score:  0.976
Data Source:  BioPlex,STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.999997785
p_ni:  0.000002215
Score:  0.984
Data Source:  BioPlex,STRINGDB
HLA-G
Tbio
Novelty:  0.0009462
p_int:  0.999293414
p_ni:  0.000706586
Score:  0.981
Data Source:  BioPlex,STRINGDB
HLA-A
Tbio
Novelty:  0.00270731
p_int:  0.998421754
p_ni:  0.001578246
Score:  0.984
Data Source:  BioPlex,STRINGDB
HLA-E
Tbio
Novelty:  0.00216583
p_int:  0.99533142
p_ni:  0.00466858
Score:  0.967
Data Source:  BioPlex,STRINGDB
CNNM1
Tdark
Novelty:  0.11053515
p_int:  0.991663377
p_ni:  0.008336484
p_wrong:  1.39e-7
Score:  0.625
Data Source:  BioPlex,STRINGDB
HLA-F
Tbio
Novelty:  0.01200285
p_int:  0.989762104
p_ni:  0.010237896
Score:  0.969
Data Source:  BioPlex,STRINGDB
TMEM30A
Tbio
Novelty:  0.05115559
p_int:  0.98431327
p_ni:  0.01568673
Data Source:  BioPlex
UFSP2
Tbio
Family:  Enzyme
Novelty:  0.12630722
p_int:  0.975514931
p_ni:  0.024485069
Data Source:  BioPlex
GPR50
Tbio
Family:  GPCR
Novelty:  0.0110136
p_int:  0.966741659
p_ni:  0.033144131
p_wrong:  0.00011421
Data Source:  BioPlex
Pathways (40)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 15
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Gene Ontology Terms (21)
Items per page:
10
1 – 1 of 1
GO Term
Evidence
Assigned by
Inferred from Sequence or structural Similarity (ISS)
UniProtKB
GWAS Traits (2100)
Items per page:
1 – 5 of 2100
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
30
99.7
lymphocyte count
4
9
50
99.7
lymphocyte count
4
9
50
99.7
Items per page:
1 – 5 of 2100
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
lymphocyte count
50
99.7
lymphocyte count
50
99.7
lymphocyte count
30
99.7
lymphocyte count
50
99.7
lymphocyte count
50
99.7
Find similar targets by:
Orthologs (1)
1 – 1 of 1
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
471962
Species
Name
OMA
EggNOG
Inparanoid
Chimp
major histocompatibility complex, class I, C
Publication Statistics
PubMed Score 1553.10
PubMed score by year
PubTator Score 2752.35
PubTator score by year