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Tbio
P10316
HLA class I histocompatibility antigen, A-69 alpha chain

Protein Summary
Description
Involved in the presentation of foreign antigens to the immune system. HLA-A belongs to the HLA class I heavy chain paralogues. This class I molecule is a heterodimer consisting of a heavy chain and a light chain (beta-2 microglobulin). The heavy chain is anchored in the membrane. Class I molecules play a central role in the immune system by presenting peptides derived from the endoplasmic reticulum lumen. They are expressed in nearly all cells. The heavy chain is approximately 45 kDa and its gene contains 8 exons. Exon 1 encodes the leader peptide, exons 2 and 3 encode the alpha1 and alpha2 domains, which both bind the peptide, exon 4 encodes the alpha3 domain, exon 5 encodes the transmembrane region, and exons 6 and 7 encode the cytoplasmic tail. Polymorphisms within exon 2 and exon 3 are responsible for the peptide binding specificity of each class one molecule. Typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. Hundreds of HLA-A alleles hav ...more
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000457879
  • ENSP00000403575
  • ENSG00000235657

Symbol
  • HLAA
  • HLAA
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
biological process
0
biological term
0
cell line
0
cell type or tissue
0
cellular component
0


Protein Classes
No PANTHER Classes or DTO Classes found
IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6562.56   (req: < 5)
Gene RIFs: 476   (req: <= 3)
Antibodies: 0   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 6562.56   (req: >= 5)
Gene RIFs: 476   (req: > 3)
Antibodies: 0   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 9
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Expression Data (0 Tissues)
No expression data found
Related Tools
Target Illumination GWAS Analytics (TIGA)
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TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
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GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
ARCHS4
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ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Approved Drugs (0)
No approved drugs found
Active Ligands (0)
No active ligands found
Protein-Protein Interactions (334)
SLC3A2
Tbio
Family:  Transporter
Novelty:  0.0021506
p_int:  0.920922309
p_ni:  0.079077691
Data Source:  BioPlex
CLEC4A
Tbio
Novelty:  0.01821643
p_int:  0.919883907
p_ni:  0.080116093
Data Source:  BioPlex
HFE
Tbio
Novelty:  0.00042077
p_int:  0.892979558
p_ni:  0.107020442
Data Source:  BioPlex
SCGB2A1
Tbio
Novelty:  0.01902973
p_int:  0.859333539
p_ni:  0.140666461
Data Source:  BioPlex
CD1A
Tbio
Novelty:  0.00090676
p_int:  0.830311951
p_ni:  0.169688049
Score:  0.17
Data Source:  BioPlex,STRINGDB
B3GALT5
Tbio
Family:  Enzyme
Novelty:  0.04158039
p_int:  0.752411539
p_ni:  0.247588461
Data Source:  BioPlex
B2M
Tbio
Novelty:  0.00011248
Score:  0.999
Data Source:  STRINGDB
LILRB1
Tbio
Novelty:  0.00463824
Score:  0.996
Data Source:  STRINGDB
PDIA3
Tbio
Family:  Enzyme
Novelty:  0.00285939
Score:  0.992
Data Source:  STRINGDB
CD8A
Tbio
Novelty:  0.00002519
Score:  0.992
Data Source:  STRINGDB
Nearest Tclin Targets (2)
Explore Nearest Tclin Targets
Pathways (48)
Adaptive Immune System (R-HSA-1280218)

Click on a row in the table to change the structure displayed.

Find Similar Targets
Items per page:
1 – 5 of 25
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Adaptive Immune System
Reactome
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Reactome
Antigen processing-Cross presentation
Reactome
Class I MHC mediated antigen processing & presentation
Reactome
Cytokine Signaling in Immune system
Name
Explore in Pharos
Explore in Source
Adaptive Immune System
Antigen Presentation: Folding, assembly and peptide loading of class I MHC
Antigen processing-Cross presentation
Class I MHC mediated antigen processing & presentation
Cytokine Signaling in Immune system
Viral Interactions (0)
No viral interactions found
Disease Associations ()
No disease associations found
GWAS Traits (344)
Items per page:
1 – 5 of 344
GWAS Trait
EFO ID
ENSG ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
5
9
40
98.8
reticulocyte count
5
9
30
98.8
reticulocyte count
5
9
30
98.8
reticulocyte count
5
9
50
98.8
eosinophil count
2
4
16
97.2
Items per page:
1 – 5 of 344
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
reticulocyte count
40
98.8
reticulocyte count
30
98.8
reticulocyte count
30
98.8
reticulocyte count
50
98.8
eosinophil count
16
97.2
Find similar targets by:
IDG Resources
No IDG generated resources found
Orthologs (3)
1 – 3 of 3
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
MHC class Ib
494187
Macaque
HLA class I histocompatibility antigen, A-11 alpha chain-like
106995876
Rat
RGD:2320860
100364500
Species
Name
OMA
EggNOG
Inparanoid
Chimp
MHC class Ib
Macaque
HLA class I histocompatibility antigen, A-11 alpha chain-like
Rat
Publication Statistics
PubMed Score 6562.56
PubMed score by year
PubTator Score 4624.69
PubTator score by year
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Related Publications
Items per page:
0 of 0
PMID
Year
Title