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Tbio
RRAS
Ras-related protein R-Ras

Protein Summary
Description
Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]
Uniprot Accession IDs
Gene Name
Ensembl ID
  • ENST00000246792
  • ENSP00000246792
  • ENSG00000126458

Symbol
  • R-Ras
Illumination Graph
Knowledge Table
Most Knowledge About
Knowledge Value (0 to 1 scale)
molecular function
0.95
interacting protein
0.92
hub protein
0.85
gene perturbation
0.83
PubMedID
0.81


IDG Development Level Summary
Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.17   (req: < 5)
Gene RIFs: 30   (req: <= 3)
Antibodies: 202   (req: <= 50)
Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 136.17   (req: >= 5)
Gene RIFs: 30   (req: > 3)
Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11
Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0
Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0
Protein Sequence and Structure
Residue Counts
Protein Sequence
ProtVista Viewer
Related Tools
Target Illumination GWAS Analytics (TIGA)
Thumbnail image for Target Illumination GWAS Analytics (TIGA)
TIGA scores and ranks GWAS discovered associations according to the quantity and quality of the evidence supporting the association.
GENEVA
Thumbnail image for GENEVA
GENEVA (GENe Expression Variance Analysis) allows you to identify RNA-sequencing datasets from the Gene Expression Omnibus (GEO) that contain conditions modulating a gene or a gene signature.
GlyGen
Thumbnail image for GlyGen
GlyGen is a data integration and dissemination project for carbohydrate and glycoconjugate related data.
ARCHS4
Thumbnail image for ARCHS4
ARCHS4 provides access to gene-function predictions based on RNA-seq co-expression, and gene expression levels across cell and tissues.
Protein-Protein Interactions (228)
1 – 10 of 228
RIN1
Tbio
Novelty:  0.02401084
p_int:  0.997861083
p_ni:  0.002138697
p_wrong:  2.2e-7
Score:  0.91
Data Source:  BioPlex,STRINGDB
IL36RN
Tbio
Novelty:  0.00659649
p_int:  0.994988362
p_ni:  0.004748841
p_wrong:  0.000262797
Data Source:  BioPlex
TMEM185A
Tdark
Novelty:  0.0262898
p_int:  0.988111702
p_ni:  0.011244422
p_wrong:  0.000643876
Data Source:  BioPlex
NCSTN
Tbio
Novelty:  0.00453935
p_int:  0.982687581
p_ni:  0.016975526
p_wrong:  0.000336893
Score:  0.208
Data Source:  BioPlex,STRINGDB
SDC1
Tbio
Novelty:  0.00044792
p_int:  0.942766625
p_ni:  0.024125688
p_wrong:  0.033107687
Score:  0.225
Data Source:  BioPlex,STRINGDB
PRDM1
Tbio
Family:  TF; Epigenetic
Novelty:  0.00224931
p_int:  0.92510317
p_ni:  0.074896807
p_wrong:  2.3e-8
Score:  0.195
Data Source:  BioPlex,STRINGDB
SSC5D
Tbio
Novelty:  0.23138499
p_int:  0.907461829
p_ni:  0.061123072
p_wrong:  0.031415099
Score:  0.234
Data Source:  BioPlex,STRINGDB
ITLN1
Tbio
Novelty:  0.00299735
p_int:  0.904319103
p_ni:  0.095654601
p_wrong:  0.000026296
Score:  0.205
Data Source:  BioPlex,STRINGDB
CCNL2
Tbio
Novelty:  0.03667817
p_int:  0.894478562
p_ni:  0.105520194
p_wrong:  0.000001243
Score:  0.188
Data Source:  BioPlex,STRINGDB
SLC25A41
Tdark
Family:  Transporter
Novelty:  1.04918395
p_int:  0.883663893
p_ni:  0.116326758
p_wrong:  0.000009349
Data Source:  BioPlex
Pathways (61)
Axon guidance (R-HSA-422475)

Click on a row in the table to change the structure displayed.

Items per page:
1 – 5 of 6
Data Source
Name
Explore in Pharos
Explore in Source
Reactome
Axon guidance
Reactome
Developmental Biology
Reactome
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Reactome
Sema4D in semaphorin signaling
Reactome
Sema4D mediated inhibition of cell attachment and migration
Name
Explore in Pharos
Explore in Source
Axon guidance
Developmental Biology
SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
Sema4D in semaphorin signaling
Sema4D mediated inhibition of cell attachment and migration
Gene Ontology Terms (14)
Items per page:
10
1 – 4 of 4
GO Term
Evidence
Assigned by
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
UniProtKB
Inferred from Direct Assay (IDA)
MGI
Inferred from Electronic Annotation (IEA)
UniProtKB-KW
GWAS Traits (29)
GWAS Trait
EFO ID
Study Count
SNP Count
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
1
5
5
96.6
hemoglobin measurement
3
3
3
91.7
serum albumin measurement
1
3
3
89.8
hematocrit
3
2
3
89.4
red blood cell density measurement
1
1
1
80.9
GWAS Trait
EFO ID
Beta Count
Odds Ratio
Evidence (Mean Rank Score)
Provenance
blood protein measurement
5
96.6
hemoglobin measurement
3
91.7
serum albumin measurement
3
89.8
hematocrit
3
89.4
red blood cell density measurement
1
80.9
Find similar targets by:
Orthologs (10)
1 – 5 of 10
Species
Name
Source ID
Gene ID
OMA
EggNOG
Inparanoid
Chimp
RAS related
468955
Macaque
RAS related
718939
Mouse
MGI:98179
20130
Rat
RGD:1311443
361568
Dog
RAS related
VGNC:49028
476413
Species
Name
OMA
EggNOG
Inparanoid
Chimp
RAS related
Macaque
RAS related
Mouse
Rat
Dog
RAS related
Publication Statistics
PubMed Score 136.17
PubMed score by year
PubTator Score 41.01
PubTator score by year