Tbio RRAS Ras-related protein R-Ras

Protein Summary

Description

Regulates the organization of the actin cytoskeleton (PubMed:16537651, PubMed:18270267). With OSPBL3, modulates integrin beta-1 (ITGB1) activity (PubMed:18270267). The protein encoded by this gene is a small GTPase involved in diverse processes including angiogenesis, vascular homeostasis and regeneration, cell adhesion, and neuronal axon guidance. Mutations in this gene are found in many invasive cancers. [provided by RefSeq, Jul 2015]

Uniprot Accession IDs

• P10301
• Q6FH12

Gene Name

• RRAS

Ensembl ID

• ENST00000246792
• ENSP00000246792
• ENSG00000126458

Symbol

• R-Ras

Knowledge Table

Most Knowledge About	Knowledge Value (0 to 1 scale)
molecular function	0.95
interacting protein	0.92
hub protein	0.85
gene perturbation	0.83
PubMedID	0.81

Protein Classes

PANTHER Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related Protein R-ras

DTO Classes

Protein / Enzyme Modulator / G-protein / Small Gtpase / Ras-related Protein R-ras

IDG Development Level Summary

Tdark

These are targets about which virtually nothing is known. They do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.07   (req: < 5)

Gene RIFs: 32   (req: <= 3)

Antibodies: 202   (req: <= 50)

Tbio

These targets do not have known drug or small molecule activities
- AND - satisfy two or more of the following criteria:

Pubmed score: 155.07   (req: >= 5)

Gene RIFs: 32   (req: > 3)

Antibodies: 202   (req: > 50)

- OR - satisfy the following criterion:

Gene Ontology Terms: 11

Tchem

Target has at least one ChEMBL compound with an activity cutoff of < 30 nM - AND - satisfies the preceding conditions

Active Ligand: 0

Tclin

Target has at least one approved drug - AND - satisfies the preceding conditions

Active Drug: 0